Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7869 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- DEDD polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human DEDD.
- Description
- Apoptosis is a physiological process by which multicellular organisms eliminate unwanted cells. DEDD (Death Effector Domain-containing DNA binding protein) induces apoptosis by triggering a series of intracellular protein-protein interactions mediated by the N-terminal DED motif. DEDD, a cytoplasmic protein, translocates to the nucleus during CD95-mediated apoptosis, where it localizes to nucleoli-like structures, activates caspase-6 and specifically inhibits RNA polymerase I-dependent transcription. The cell death activity of DEDD relates to its nuclear localization. The DED in DEDD is sufficient for its DNA binding, capspase-6 activating and Pol I specific transcriptional repressor activity. Point specific mutations indicate that the DED in DEDD represents a novel domain that is structually similar to other DEDs but functionally different from classical DEDs found in FADD or caspase-8. DEDD is widely expressed in a variety of tissues, with highest levels in the testis. The human DEDD gene maps to chromosome 1q23.3. Alternative splicing results in two transcript variants which encode the same protein.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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