BS7869

antibody from Bioworld Technology, Inc

Targeting: DEDD CASP8IP1, DEDD1, DEFT, FLDED1, KE05

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS7869

Provider

Bioworld Technology, Inc

Product name

DEDD polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human DEDD.

Description

Apoptosis is a physiological process by which multicellular organisms eliminate unwanted cells. DEDD (Death Effector Domain-containing DNA binding protein) induces apoptosis by triggering a series of intracellular protein-protein interactions mediated by the N-terminal DED motif. DEDD, a cytoplasmic protein, translocates to the nucleus during CD95-mediated apoptosis, where it localizes to nucleoli-like structures, activates caspase-6 and specifically inhibits RNA polymerase I-dependent transcription. The cell death activity of DEDD relates to its nuclear localization. The DED in DEDD is sufficient for its DNA binding, capspase-6 activating and Pol I specific transcriptional repressor activity. Point specific mutations indicate that the DED in DEDD represents a novel domain that is structually similar to other DEDs but functionally different from classical DEDs found in FADD or caspase-8. DEDD is widely expressed in a variety of tissues, with highest levels in the testis. The human DEDD gene maps to chromosome 1q23.3. Alternative splicing results in two transcript variants which encode the same protein.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.