CLK1

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Description

CDC like kinase 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear membrane

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

2 (200853009 - 200864744)

Ensembl ID

ENSG00000013441  (ver. 103.38)

Orthologs

Mouse Clk1: ENSMUSG00000026034

UniProt

P49759

neXtProt

NX_P49759

Human splice variants
Mouse splice variants

Protein structure