BS2556

antibody from Bioworld Technology, Inc
Targeting: CLK1
Provider product page for BS2556
Western blot
Immunohistochemistry

Antibody data

Product number
BS2556 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CLK1 (R126) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 100-150 of Human CLK1.
Description
The CDC-like kinase 1 (CLK1) dually phosphorylates serine and arginine rich proteins of the spliceosomal complex, which constitutes a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Specifically, CLK1 may mediate the release of specific proteins from nuclear storage sites. Expression of CLK1 may be very low due to a premature stop codon in the mRNA, which leads to nonsense-mediated mRNA decay. CLK1 activity is positively regulated by phosphorylation on either tyrosine residues or serine/ threonine residues, and is negatively regulated by steric constraints mediated by the N-terminal domain, and also by phosphorylation on a subset of serine/threonine residues within the catalytic domain.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CLK1 protein structure - BS2556 shown in red.