TXNDC5

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

Description

Thioredoxin domain containing 5

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (7881517 - 7910788)

Ensembl ID

ENSG00000239264  (ver. 103.38)

Orthologs

Mouse Txndc5: ENSMUSG00000038991

UniProt

Q8NBS9

neXtProt

NX_Q8NBS9

Human splice variants
Mouse splice variants

Protein structure