Antibody data

Product number
10-7560 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-CD10 Antibody
Antibody type
Monoclonal
Description
CD10, also known as membrane metalloendopeptidase, neutral endopeptidase, neprilysin and common acute lymphoblastic leukaemia antigen (CALLA), is a zinc-dependent metalloendoprotease that cleaves signaling peptides. It is widely expressed in various normal tissues and in epithelial, stromal or both components of various malignancies. CD10 is a marker for intestinal epithelial brush border. It is also present in normal bile ducts and gallbladder epithelia but is absent in cholangiocarcinomas. It is con-sidered as the prototype of this family of membrane-bound, zinc-dependent endopeptidases, which regulate the physiological action of various peptides by lowering their extracellular concentration available for receptor binding. CD10 is also known to be an amyloid b-peptide (Ab) degrading enzyme. Polymorphisms in the CD10 gene increase the risk for Alzheimers disease. Outside the nervous system, it is present on the surface of neutrophils and regulates their activation by degradation of in?ammatory peptides.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant CD10 p
rotein (amino acids 282-496) was us
ed as the immunogen for this antibo
dy.
Isotype
IgG
Antibody clone number
ABM4A52
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
MME protein structure - 10-7560 shown in red.