abx015726

antibody from Abbexa

Targeting: MME CALLA, CD10, NEP

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx015726

Provider

Abbexa

Product name

Neprilysin / NEP (MME) Antibody

Antibody type

Monoclonal

Description

CD10 (MME): membrane metallo-endopeptidase.This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL).This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL.This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues.It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium.The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb.The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts.The coding region is not affected by alternative splicing.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.