312206

antibody from BioLegend

Targeting: MME CALLA, CD10, NEP

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

312206

Provider

BioLegend

Proper citation

BioLegend Cat#312206, RRID:AB_314917

Product name

PE/Cy5 anti-human CD10

Antibody type

Monoclonal

Antigen

CD10

Description

CD10 is a 100 kD neutral endopeptidase and a member of the metalloprotease family. It is a type II transmembrane protein also known as common acute lymphoblastic leukemia antigen (CALLA), enkephalinase, and neprilysin. CD10 is expressed on B cell precursors, T cell precursors, and neutrophils. CD10 is involved in B cell development and has been shown to bind opioid enkephalins, bradykinin, angiotensins I and II, and other biologically active peptides.

Reactivity

Human, Simian

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

100 tests

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

References

Submitted references

Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

Villanueva E, Yalavarthi S, Berthier CC, Hodgin JB, Khandpur R, Lin AM, Rubin CJ, Zhao W, Olsen SH, Klinker M, Shealy D, Denny MF, Plumas J, Chaperot L, Kretzler M, Bruce AT, Kaplan MJ
Journal of immunology (Baltimore, Md. : 1950) 2011 Jul 1;187(1):538-52

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A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs.

Denny MF, Yalavarthi S, Zhao W, Thacker SG, Anderson M, Sandy AR, McCune WJ, Kaplan MJ
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):3284-97

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human pre- B cell line stained with HI10a PE/Cy5

Conjugate

Yellow dye