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- Antibody Data
- Antigen structure
- References [25]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 12834-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12834-1-AP, RRID:AB_10597094
- Product name
- HDAC6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HDAC6 antibody (Cat. #12834-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6.
S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.
HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation.
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.
Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage.
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Inhibition of Histone Deacetylase 6 by Tubastatin A Attenuates the Progress of Osteoarthritis via Improving Mitochondrial Function.
Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System.
RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.
Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.
Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway.
Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Histone deacetylases and acetylated histone H3 are involved in the process of hepatitis B virus DNA replication.
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.
Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.
An Interaction Landscape of Ubiquitin Signaling.
Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging.
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Kai H, Wu Q, Yin R, Tang X, Shi H, Wang T, Zhang M, Pan C
Frontiers in cell and developmental biology 2021;9:701628
Frontiers in cell and developmental biology 2021;9:701628
S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.
Zhang L, Zhang Z, Li C, Zhu T, Gao J, Zhou H, Zheng Y, Chang Q, Wang M, Wu J, Ran L, Wu Y, Miao H, Zou X, Liang B
Cellular and molecular gastroenterology and hepatology 2021;11(3):697-724
Cellular and molecular gastroenterology and hepatology 2021;11(3):697-724
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Yan X, Qu X, Liu B, Zhao Y, Xu L, Yu S, Wang J, Wang L, Su J
Frontiers in oncology 2021;11:742460
Frontiers in oncology 2021;11:742460
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.
Gopalan J, Omar MH, Roy A, Cruz NM, Falcone J, Jones KN, Forbush KA, Himmelfarb J, Freedman BS, Scott JD
eLife 2021 Jul 12;10
eLife 2021 Jul 12;10
HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation.
Zhan Y, Wang H, Zhang L, Pei F, Chen Z
Frontiers in cell and developmental biology 2020;8:605609
Frontiers in cell and developmental biology 2020;8:605609
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W
Frontiers in microbiology 2020;11:78
Frontiers in microbiology 2020;11:78
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.
Tang K, Li S, Li P, Xia Q, Yang R, Li T, Li L, Jiang Y, Qin X, Yang H, Wu C, You F, Tan Y, Liu Y
Biochimica et biophysica acta. Molecular cell research 2020 May;1867(5):118676
Biochimica et biophysica acta. Molecular cell research 2020 May;1867(5):118676
Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage.
Yao Y, Hao F, Tang LC, Xu XH, Jin L
Molecular human reproduction 2020 Jul 1;26(7):521-531
Molecular human reproduction 2020 Jul 1;26(7):521-531
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Zheng Z, Zhou Y, Ye L, Lu Q, Zhang K, Zhang J, Xie L, Wu Y, Xu K, Zhang H, Xiao J
Experimental neurology 2020 Feb;324:113138
Experimental neurology 2020 Feb;324:113138
Inhibition of Histone Deacetylase 6 by Tubastatin A Attenuates the Progress of Osteoarthritis via Improving Mitochondrial Function.
Zheng Y, Chen Y, Lu X, Weng Q, Dai G, Yu Y, Yu K, Gao W
The American journal of pathology 2020 Dec;190(12):2376-2386
The American journal of pathology 2020 Dec;190(12):2376-2386
Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System.
Liu J, Kang Y, Yin S, Chen A, Wu J, Liang H, Shao L
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901073
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901073
RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.
Zhang Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC
Molecular human reproduction 2019 Jul 1;25(7):359-372
Molecular human reproduction 2019 Jul 1;25(7):359-372
Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.
Wang HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH, Sun SC
Development (Cambridge, England) 2019 Feb 4;146(3)
Development (Cambridge, England) 2019 Feb 4;146(3)
Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway.
Fu Z, Li F, Jia L, Su S, Wang Y, Cai Z, Xiang M
The Journal of thoracic and cardiovascular surgery 2019 Aug;158(2):408-417.e2
The Journal of thoracic and cardiovascular surgery 2019 Aug;158(2):408-417.e2
Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.
Markmiller S, Fulzele A, Higgins R, Leonard M, Yeo GW, Bennett EJ
Cell reports 2019 Apr 30;27(5):1356-1363.e3
Cell reports 2019 Apr 30;27(5):1356-1363.e3
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, Zhao H, Xie M, Lu F, Fang Q, Liang W, Yin F, Li Z
Cancer research 2019 Apr 15;79(8):1769-1783
Cancer research 2019 Apr 15;79(8):1769-1783
Histone deacetylases and acetylated histone H3 are involved in the process of hepatitis B virus DNA replication.
Zhang D, Wang Y, Zhang HY, Jiao FZ, Zhang WB, Wang LW, Zhang H, Gong ZJ
Life sciences 2019 Apr 15;223:1-8
Life sciences 2019 Apr 15;223:1-8
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Wobst HJ, Wesolowski SS, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, Deeb TZ, Dunlop J, Brandon NJ, Moss SJ
Frontiers in molecular neuroscience 2017;10:46
Frontiers in molecular neuroscience 2017;10:46
Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.
Jian W, Wei X, Chen L, Wang Z, Sun Y, Zhu S, Lou H, Yan S, Li X, Zhou J, Zhang B
Neuroscience letters 2017 Sep 29;658:114-120
Neuroscience letters 2017 Sep 29;658:114-120
Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.
Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, Li J, Zhao A, Liu J
British journal of cancer 2017 Mar 28;116(7):903-911
British journal of cancer 2017 Mar 28;116(7):903-911
An Interaction Landscape of Ubiquitin Signaling.
Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M
Molecular cell 2017 Mar 2;65(5):941-955.e8
Molecular cell 2017 Mar 2;65(5):941-955.e8
Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging.
Li Q, Ma Y, Zhu Y, Zhang T, Zhou Y
Journal of periodontology 2017 Jan;88(1):e12-e23
Journal of periodontology 2017 Jan;88(1):e12-e23
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Wang Z, Tang F, Hu P, Wang Y, Gong J, Sun S, Xie C
Oncology reports 2016 Jul;36(1):589-97
Oncology reports 2016 Jul;36(1):589-97
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92
Oncology reports 2015 Feb;33(2):685-92
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 12834-1-AP(HDAC6 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HDAC6 (IP:12834-1-AP, 5ug; Detection:12834-1-AP 1:1000) with K-562 cells lysate 11000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 12834-1-AP(HDAC6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HDAC6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HDAC6. This antibody recognizes human antigen. The HDAC6 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
