A010-50AP

antibody from Badrilla Ltd
Targeting: CAMK2A CAMKA, CaMKIINalpha, CaMKIIα, KIAA0968
Provider product page for A010-50AP

Antibody data

Product number
A010-50AP - Provider product page
Provider
Badrilla Ltd
Product name
CaMK II Phospho Threonine-286 (AP) IgG
Antibody type
Polyclonal
Antigen
Synthetic peptide
Description
Ca2+/calmodulin-dependent kinase II (CaMKII) is a ubiquitous, multifunctional serine/threonine kinase involved in translating Ca2+- transient signals into cellular responses. Four separate CaMKII genes are expressed in man (α, β, γ, δ) with isoforms within each gene. CaMKII γ and δ are abundant in the heart. CaMKII is activated by Ca2+/CaM binding, and becomes activated for prolonged periods of time following autophosphorylation of Thr-286 or Thr-287 (equivalent residues in different isoforms). This antibody recognizes the active, autophosphorylated enzyme (all isoforms) and thus can measure the abundance of active CaMKII. Prolonged activation of CaMKII is associated with a variety of vascular and cardiac diseases including stroke, atrial fibrillation cardiac arrhythmia & sudden death, cardiac apoptosis, and heart failure.
Reactivity
Human, Rat, Bovine, Porcine, Rabbit
Host
Rabbit
Antigen sequence
(M281HRQET(PO3H2)VDC289)
Isotype
IgG
Vial size
50 µl
Storage
Lyophilised: 4 °C Reconstituted:-80 °C
Handling
Reconstitute lyophilised powder in 50 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles
CAMK2A protein structure - A010-50AP shown in red.