NRP1

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]

Description

Neuropilin 1

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Membrane, Secreted in other tissues

Protein family

Cancer-related genes
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Transporters

Chromosome

10 (33177492 - 33336262)

Ensembl ID

ENSG00000099250  (ver. 103.38)

Orthologs

Mouse Nrp1: ENSMUSG00000025810

UniProt

O14786

neXtProt

NX_O14786

Human splice variants
Mouse splice variants

Protein structure