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Protein structure
TGIF1
TGFB induced factor homeobox 1HPE4, TGIF
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Top validated antibodies |
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| Santa Cruz Biotechnology |  sc-17800 |
3 references | Monoclonal |
WB
IHC
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| Cusabio Biotech Co., Ltd | CSB-PA623005LA01HU |
Polyclonal |
WB
EL
ICC
IHC
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| LSBio | LS-C500893 |
Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN2845378 |
2 references | Polyclonal |
WB
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| Affinity Biosciences | DF7689 |
Polyclonal |
WB
EL
ICC
|
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