Tissue expression
Cell line expression
Protein structure
TRADD
TNFRSF1A associated via death domainHs.89862
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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antibodies-online | ![]() |
2 references | Polyclonal |
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Proteintech Group | ![]() |
5 references | Polyclonal |
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Abgent | ![]() |
Polyclonal |
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Acris Antibodies GmbH | ![]() |
Polyclonal |
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OriGene | ![]() |
Polyclonal |
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