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- Antibody Data
- Antigen structure
- References [517]
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- Product number
- 10993-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10993-1-AP, RRID:AB_2090467
- Product name
- Cytochrome c antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Cytochrome c antibody (Cat. #10993-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Establishment of XRD fourier fingerprint identification method of realgar decoction pieces and its anti-tumor activity in tumor-in-situ transplanted mice.
SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.
Placenta-derived exosomes as carriers of non-coding RNAs in maternal circulation of patients with preeclampsia.
Study on the mechanism of arsenic-induced renal injury based on SWATH proteomics technology.
Complement C1q is involved in the activation of membrane attack complexes, regulation of bacterial infectious inflammation, and apoptosis through overexpression in primary cells of silver pomfret (Pampus argenteus) in vitro.
Betulinic acid inhibits the proliferation of human laryngeal carcinoma cells through reactive oxygen species-mediate mitochondrial apoptotic pathway.
Quercetin alleviates the toxicity of difenoconazole to the respiratory system of carp by reducing ROS accumulation and maintaining mitochondrial dynamic balance.
Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons.
T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway.
Metformin switches cell death modes to soothe the apical periodontitis via ZBP1.
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells.
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis.
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics.
PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release.
FUNDC1-induced mitophagy protects spinal cord neurons against ischemic injury.
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis.
Gentiopicroside inhibits the progression of gastric cancer through modulating EGFR/PI3K/AKT signaling pathway.
MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes.
Cold atmospheric plasma stabilizes mismatch repair for effective, uniform treatment of diverse colorectal cancer cell types.
Nanopore-related cellular death through cytoskeleton depolymerization by drug-induced ROS.
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats.
Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion.
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma.
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjögren's syndrome.
Exercise prevents fatal stress-induced myocardial injury in obese mice.
E. coli Nissle 1917 ameliorates mitochondrial injury of granulosa cells in polycystic ovary syndrome through promoting gut immune factor IL-22 via gut microbiota and microbial metabolism.
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
Electroacupuncture preconditioning protects against myocardial ischemia-reperfusion injury by modulating dynamic inflammatory response.
Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta(2) C Modified with Chondroitin Sulfate (TACS).
Human placenta-derived mesenchymal stem cell administration protects against acute lung injury in a mouse model.
Osteogenic microenvironment affects palatal development through glycolysis.
A Terphenyllin Derivative CHNQD-00824 from the Marine Compound Library Induced DNA Damage as a Potential Anticancer Agent.
Bilobalide Induces Apoptosis in 3T3-L1 Mature Adipocytes through ROS-Mediated Mitochondria Pathway.
Stereospecificity of Ginsenoside AD-1 and AD-2 Showed Anticancer Activity via Inducing Mitochondrial Dysfunction and Reactive Oxygen Species Mediate Cell Apoptosis.
Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway.
Long-term iTBS Improves Neural Functional Recovery by Reducing the Inflammatory Response and Inhibiting Neuronal Apoptosis Via miR-34c-5p/p53/Bax Signaling Pathway in Cerebral Ischemic Rats.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway.
Dietary Taurine Supplementation Improves the Meat Quality, Muscle Fiber Type, and Mitochondrial Function of Finishing Pigs.
Metformin alleviates cerebral ischemia/reperfusion injury aggravated by hyperglycemia via regulating AMPK/ULK1/PINK1/Parkin pathway-mediated mitophagy and apoptosis.
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp.
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.
Methylcrotonyl-CoA carboxylase subunit 1 (MCCA) regulates multidrug resistance in multiple myeloma.
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.
Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes.
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication.
Oral Metal-Free Melanin Nanozymes for Natural and Durable Targeted Treatment of Inflammatory Bowel Disease (IBD).
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.
SAR-guided development of indole-matrine hybrids as potential anticancer agents via mitochondrial stress/cytochrome c/caspase 3 signaling pathway.
Unraveling the potential of senescence-related genes in guiding clinical therapy of lung adenocarcinoma patients.
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Cytotoxic steroidal glycosides from the rhizomes of Paris polyphylla var. yunnanensis.
Sirt3-dependent regulation of mitochondrial oxidative stress and apoptosis contributes to the dysfunction of pancreatic islets after severe burns.
miR‑222-3p reduces neuronal cell apoptosis and alleviates spinal cord injury by inhibiting Bbc3 and Bim.
Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.
PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.
Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway.
Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes.
HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome.
Mir-153-3p Modulates the Breast Cancer Cells' Chemosensitivity to Doxorubicin by Targeting KIF20A.
Novel antioxidant peptides from MFGM protein Hydrolysates: Separation, identification and effects on Dexamethasone-induced mitochondrial dysfunction.
Exploring the potential of ginseng glycoprotein to improve learning and memory in mice via Notch signaling pathway and structural analysis using multi-information fusion based on liquid chromatography-mass spectrometry.
Aidi injection enhances the anti-tumor impact of doxorubicin in H22 tumor-containing mice.
Toosendanin-induced apoptosis of CMT-U27 is mediated through the mitochondrial apoptotic pathway.
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway.
Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.
Neuroprotective mechanisms of OXCT1 via the SIRT3-SOD2 pathway after traumatic brain injury.
DR1-CSE/H(2)S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose.
Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma.
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.
Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
A mitochondria-targeting ROS-activated nanoprodrug for self-augmented antitumor oxidation therapy.
Liensinine, a alkaloid from lotus plumule, mitigates lipopolysaccharide-induced sepsis-associated encephalopathy through modulation of nuclear factor erythroid 2-related factor-mediated inflammatory biomarkers and mitochondria apoptosis.
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Myeloid-derived suppressor cells ameliorate liver mitochondrial damage to protect against autoimmune hepatitis by releasing small extracellular vesicles.
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest.
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress.
Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease.
Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway.
Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Mitochondrial targeting half-sandwich iridium(III) and ruthenium(II) dppf complexes and in vitro anticancer assay.
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction.
Spleen Toxicity of Organophosphorus Flame Retardant TDCPP in Mice and the Related Mechanisms.
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells.
To explore the regulatory role of Wnt/P53/Caspase3 signal in mouse ovarian development based on LFQ proteomics.
Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury.
Epothilone B inactivation of Sirtuin1 promotes mitochondrial reactive oxygen species to induce dysfunction and ferroptosis of Schwann cells.
Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT.
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis.
Cirsiliol induces autophagy and mitochondrial apoptosis through the AKT/FOXO1 axis and influences methotrexate resistance in osteosarcoma.
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification.
SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria.
Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway.
Treatment with FAP-targeted zinc ferrite nanoparticles for rheumatoid arthritis by inducing endoplasmic reticulum stress and mitochondrial damage.
Difenoconazole disrupts carp intestinal physical barrier and causes inflammatory response via triggering oxidative stress and apoptosis.
Multi-Catcher Polymers Regulate the Nucleolin Cluster on the Cell Surface for Cancer Therapy.
The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.
Inhibition of autophagic flux by the curcumin analog EF-24 and its antiproliferative effect on MCF-7 cancer cells.
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia.
Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole.
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
The Exploration of miRNAs From Porcine Fallopian Tube Stem Cells on Porcine Oocytes.
Methylcobalamin Alleviates Neuronal Apoptosis and Cognitive Decline Induced by PM2.5 Exposure in Mice.
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
CORM-3 Attenuates Oxidative Stress-Induced Bone Loss via the Nrf2/HO-1 Pathway.
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.
Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Ras-related protein Rab-20 inhibition alleviates cerebral ischemia/reperfusion injury by inhibiting mitochondrial fission and dysfunction.
Cryptotanshinone alleviates myocardial ischemia and reperfusion injury in rats to mitigate ER stress-dependent apoptosis by modulating the JAK1/STAT3 axis.
GPR27 Regulates Hepatocellular Carcinoma Progression via MAPK/ERK Pathway.
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice.
Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis.
Ultra-small molybdenum-based nanodots as an antioxidant platform for effective treatment of periodontal disease.
Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30.
Improvement of anticancer effect of berberine by salt formation modifications.
Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer.
FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.
Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways.
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
Mammary Fibrosis Tendency and Mitochondrial Adaptability in Dairy Cows with Mastitis.
Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy.
Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia.
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells.
Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice.
Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.
Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells.
Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle.
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Dietary lycopene supplementation improves meat quality, antioxidant capacity and skeletal muscle fiber type transformation in finishing pigs.
Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control.
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats.
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Dopamine 1 receptors inhibit apoptosis via activating CSE/H(2) S pathway in high glucose-induced vascular endothelial cells.
Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring.
Duck Tembusu virus infection induces mitochondrial-mediated and death receptor-mediated apoptosis in duck embryo fibroblasts.
Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in vivo.
DR1 activation promotes vascular smooth muscle cell apoptosis via up-regulation of CSE/H(2) S pathway in diabetic mice.
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Protective effects of hydroxy-α-sanshool from the pericarp of Zanthoxylum bungeanum Maxim. On D-galactose/AlCl(3)-induced Alzheimer's disease-like mice via Nrf2/HO-1 signaling pathways.
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
PTX3 alleviates hard metal-induced acute lung injury through potentiating efferocytosis.
TERT Promoter Revertant Mutation Inhibits Melanoma Growth through Intrinsic Apoptosis.
Neuroprotective Effects of Tetrahydroxystilbene Glucoside against Rotenone-Induced Toxicity in PC12 Cells.
DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease.
Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells.
Resveratrol reduces DRP1-mediated mitochondrial dysfunction via the SIRT1-PGC1α signaling pathway in manganese-induced nerve damage in mice.
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway.
Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer.
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Prenatal exposure to environmentally relevant levels of PBDE-99 leads to testicular dysgenesis with steroidogenesis disorders.
Resolvin D1 attenuates sepsis induced acute kidney injury targeting mitochondria and NF-κB signaling pathway.
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
Sevelamer arsenite nanoparticle as a Pi-responsive drug carrier and embolic agent for chemoembolization.
Nickel nanoparticles exert cytotoxic effects on trophoblast HTR-8/SVneo cells possibly via Nrf2/MAPK/caspase 3 pathway.
Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES.
Exogenous hydrogen sulfide inhibits the senescence of cardiomyocytes through modulating mitophagy in rats.
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function.
Effect of low energy shock wave on testicular microenvironment homeostasis in rats.
Cyclometalated iridium(III) dithioformic acid complexes as mitochondria-targeted imaging and anticancer agents.
Design, synthesis, and in vitro protective effect evaluation of α-carboline derivatives against H(2)O(2)-induced cardiomyocyte injury.
Direct Analysis of Mitochondrial Damage Caused by Misfolded/Destabilized Proteins.
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels.
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.
Inhibition of α-Synuclein Accumulation Improves Neuronal Apoptosis and Delayed Postoperative Cognitive Recovery in Aged Mice.
Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice.
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo.
High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury - A Potential Mechanism for Obstructive Sleep Apnea with Obesity.
Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis.
Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.
BLM interaction with EZH2 regulates MDM2 expression and is a poor prognostic biomarker for prostate cancer.
Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin.
PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma.
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Design and Synthesis of Novel Betulin Derivatives Containing Thio-/Semicarbazone Moieties as Apoptotic Inducers through Mitochindria-Related Pathways.
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.
Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.
Alantolactone suppresses the metastatic phenotype and induces the apoptosis of glioblastoma cells by targeting LIMK kinase activity and activating the cofilin/G‑actin signaling cascade.
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
Nicotinamide ameliorates energy deficiency and improves retinal function in Cav-1(-/-) mice.
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats.
Scutellarin ameliorates high glucose-induced vascular endothelial cells injury by activating PINK1/Parkin-mediated mitophagy.
Plumbagin, a Biomolecule with (Anti)Osteoclastic Properties.
FGF1(ΔHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Thymoquinone improves testicular damage and sperm quality in experimentally varicocele-induced adolescent rats.
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Apoptotic caspases suppress Mycobacterium bovis-induced IFN-β production in murine macrophage.
Quantitative proteomics and bioinformatics analyses reveal the protective effects of cyanidin-3-O-glucoside and its metabolite protocatechuic acid against 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced cytotoxicity in HepG2 cells via apoptosis-related pathways.
Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling.
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer.
Selenium Deficiency-Induced Damage and Altered Expression of Mitochondrial Biogenesis Markers in the Kidneys of Mice.
Remote Ischemic Postconditioning Inhibits Hippocampal Neuronal Apoptosis and Mitophagy After Cardiopulmonary Resuscitation in Rats.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.
Discovery of a PROTAC targeting ALK with in vivo activity.
AK003290 Protects Myocardial Cells Against Apoptosis and Promotes Cardiac Function Recovery Via miR-539-3p/ErbB4 Axis in Ischemic-Reperfusion Injury.
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice.
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines.
Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling.
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Lycopene increases the proportion of slow-twitch muscle fiber by AMPK signaling to improve muscle anti-fatigue ability.
6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Cypermethrin induces Sertoli cell apoptosis through mitochondrial pathway associated with calcium.
Mitochondrial Voltage-Dependent Anion Channel 1-Hexokinase-II Complex-Targeted Strategy for Melanoma Inhibition Using Designed Multiblock Peptide Amphiphiles.
Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells.
S-adenosylmethionine decarboxylase 1 and its related spermidine synthesis mediate PM(2.5) exposure-induced neuronal apoptosis.
Effects of apple polyphenols on myofiber-type transformation in longissimus dorsi muscle of finishing pigs.
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway.
Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway.
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress.
L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson's Disease by Regulating Glutamine Metabolism.
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
Dexmedetomidine Mediates Neuroglobin Up-Regulation and Alleviates the Hypoxia/Reoxygenation Injury by Inhibiting Neuronal Apoptosis in Developing Rats.
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis.
Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF-α-mediated osteoclast autophagy.
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells.
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
T-type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation.
Transcriptomic and Proteomic Analysis Reveals Mechanisms of Patulin-Induced Cell Toxicity in Human Embryonic Kidney Cells.
The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat.
Anthocyanins from Aronia melanocarpa Induce Apoptosis in Caco-2 Cells through Wnt/β-Catenin Signaling Pathway.
Drp1-mediated mitochondrial fission induced autophagy attenuates cell apoptosis caused by 3-chlorpropane-1,2-diol in HEK293 cells.
Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Down-regulation of miR-383-5p suppresses apoptosis in oxidative stress rat hepatocytes by targeting Bcl2.
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells.
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Antihypertensive and renal protective effect of Shunaoxin pill combined with captopril on spontaneous hypertension rats.
Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction.
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Arginine promotes porcine type I muscle fibres formation through improvement of mitochondrial biogenesis.
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and -resistant chronic myeloid leukaemia cells.
lncRNA MIRF Promotes Cardiac Apoptosis through the miR-26a-Bak1 Axis.
Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.
TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation.
Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Novel diosgenin derivatives containing 1,3,4-oxadiazole/thiadiazole moieties as potential antitumor agents: Design, synthesis and cytotoxic evaluation.
Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA(2) phosphorylation in experimental ischemic stroke.
Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-/- mice via p66shc/cytochrome C cascade.
Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo.
S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis.
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.
Tongmai formula improves cardiac function via regulating mitochondrial quality control in the myocardium with ischemia/reperfusion injury.
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Latcripin-7A, derivative of Lentinula edodes C(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1) phase in breast cancer cells.
Ginsenoside M1 Induces Apoptosis and Inhibits the Migration of Human Oral Cancer Cells.
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Long non-coding RNA CRNDE promotes malignant progression of hepatocellular carcinoma through the miR-33a-5p/CDK6 axis.
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Angelica sinensis extract protects against ischemia-reperfusion injury in the hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats.
Sepiapterin reductase promotes hepatocellular carcinoma progression via FoxO3a/Bim signaling in a nonenzymatic manner.
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.
Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70/Bcl-2- and HSP70/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats.
DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway.
Tandem Molecular Self-Assembly Selectively Inhibits Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress.
LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Homer1a Attenuates Endoplasmic Reticulum Stress-Induced Mitochondrial Stress After Ischemic Reperfusion Injury by Inhibiting the PERK Pathway.
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway.
Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.
Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure.
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling.
Comparison of hypoxic effects induced by chemical and physical hypoxia on cardiomyocytes.
Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells.
Fibrin matrix containing high-dose calcitriol promotes the apoptosis of gastric cancer cells by sustainably releasing calcitrol and D-dimer.
Cocktail Strategy Based on NK Cell-Derived Exosomes and Their Biomimetic Nanoparticles for Dual Tumor Therapy.
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.
Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy.
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection.
Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.
Activation of Nrf2 signaling by Icariin protects against 6-OHDA-induced neurotoxicity.
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
Mitochondrial separation protein inhibitor inhibits cell apoptosis in rat lungs during intermittent hypoxia.
Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
H(2)S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling.
Effects of okadaic acid and hematein on human lung adenocarcinoma A549 cells and responses of mitochondria and endoplasmic reticulum apoptosis pathways.
Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release.
Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia.
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells.
2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2.
Crocin protects against dexamethasone‑induced osteoblast apoptosis by inhibiting the ROS/Ca2+‑mediated mitochondrial pathway.
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway.
TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway.
Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.
The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells.
Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.
A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis.
Leucine regulates slow-twitch muscle fibers expression and mitochondrial function by Sirt1/AMPK signaling in porcine skeletal muscle satellite cells.
Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats.
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Casticin inhibits esophageal cancer cell proliferation and promotes apoptosis by regulating mitochondrial apoptotic and JNK signaling pathways.
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ferulic acid ameliorates cerebral infarction by activating Akt/mTOR/4E‑BP1/Bcl‑2 anti‑apoptotic signaling in the penumbral cortex following permanent cerebral ischemia in rats.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy.
A novel iron(II) phenanthroline complex exhibits anticancer activity against TFR1-overexpressing esophageal squamous cell carcinoma cells through ROS accumulation and DNA damage.
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
Protective effects of ethyl gallate on H(2)O(2)-induced mitochondrial dysfunction in PC12 cells.
Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.
Glucocorticoid induces osteonecrosis of the femoral head in rats through GSK3β-mediated osteoblast apoptosis.
Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells.
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study.
Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer.
The Role of TLR4 on PGC-1α-Mediated Oxidative Stress in Tubular Cell in Diabetic Kidney Disease.
p66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke.
Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction.
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.
Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy.
The effect of shear on the cytoskeleton remodeling and physiological performance of myocardium cells through Tmod1.
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Cattle Encephalon Glycoside and Ignotin Reduce Early Brain Injury and Cognitive Dysfunction after Subarachnoid Hemorrhage in Rats.
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Acrolein-induced autophagy-dependent apoptosis via activation of the lysosomal-mitochondrial pathway in EAhy926 cells.
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.
Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells.
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.
Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.
Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells.
Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.
SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release.
Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis.
Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration.
Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity.
Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Angelica sinensis Exerts Angiogenic and Anti-apoptotic Effects Against Cerebral Ischemia-Reperfusion Injury by Activating p38MAPK/HIF-1[Formula: see text]/VEGF-A Signaling in Rats.
Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway.
Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice.
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Intranasal Delivery of a Caspase-1 Inhibitor in the Treatment of Global Cerebral Ischemia.
Tilianin Post-Conditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondrial Protection and Inhibition of Apoptosis.
Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis.
Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression.
Inhibited effects of CAPE-pNO(2) on cervical carcinoma in vivo and in vitro and its detected metabolites.
Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.
Mitochondrial Dysfunction and Ca(2+) Overload in Injured Sertoli Cells Exposed to Bisphenol A.
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca(2+)-Dependent Antioxidant Response.
Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway.
Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis.
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition and mitochondrial dysfunction.
Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models.
Triggering of apoptosis in osteosarcoma cells by graphene/single-walled carbon nanotube hybrids via the ROS-mediated mitochondrial pathway.
ABT737 induces mitochondrial pathway apoptosis and mitophagy by regulating DRP1-dependent mitochondrial fission in human ovarian cancer cells.
Ablation of β,β-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.
Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells.
CO-releasing molecules-2 attenuates ox-LDL-induced injury in HUVECs by ameliorating mitochondrial function and inhibiting Wnt/β-catenin pathway.
Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Activation of Na(+)-K(+)-ATPase with DRm217 attenuates oxidative stress-induced myocardial cell injury via closing Na(+)-K(+)-ATPase/Src/Ros amplifier.
Inhibition of p66Shc-mediated mitochondrial apoptosis via targeting prolyl-isomerase Pin1 attenuates intestinal ischemia/reperfusion injury in rats.
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes.
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.
Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells.
Ferulic Acid Administered at Various Time Points Protects against Cerebral Infarction by Activating p38 MAPK/p90RSK/CREB/Bcl-2 Anti-Apoptotic Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion Injury in Rats.
Improvement and enhancement of antibladder carcinoma cell effects of heteronemin by the nanosized hyaluronan aggregation.
Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition.
Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation.
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.
Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8/3.
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.
Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock.
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Pim-2 protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced apoptosis via downregulation of Bim expression.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells.
Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.
PUMA and survivin are involved in the apoptosis of HepG2 cells induced by microcystin-LR via mitochondria-mediated pathway.
ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway.
Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction.
Exogenous spermine ameliorates high glucose-induced cardiomyocytic apoptosis via decreasing reactive oxygen species accumulation through inhibiting p38/JNK and JAK2 pathways.
Inhibition of Hepatocyte Apoptosis: An Important Mechanism of Corn Peptides Attenuating Liver Injury Induced by Ethanol.
Cold-inducible RNA-binding protein inhibits neuron apoptosis through the suppression of mitochondrial apoptosis.
An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells.
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome.
SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells.
Novel distribution of calreticulin to cardiomyocyte mitochondria and its increase in a rat model of dilated cardiomyopathy.
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
Emodin regulates apoptotic pathway in human liver cancer cells.
Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer.
Induction of apoptosis in infantile hemangioma endothelial cells by propranolol.
Alantolactone induces activation of apoptosis in human hepatoma cells.
Alterations of mitochondrial protein assembly and jasmonic acid biosynthesis pathway in Honglian (HL)-type cytoplasmic male sterility rice.
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
Qian X, Wang Y, Liu Z, Fang F, Ma Y, Zhou L, Pan Y, Meng X, Yan B, Zhu X, Wang X, Zhao J, Liu S
Journal of ethnopharmacology 2024 Sep 15;331:118303
Journal of ethnopharmacology 2024 Sep 15;331:118303
SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.
Zhao Q, Zhou GY, Niu Q, Chen JW, Li P, Tian ZY, Li DJ, Xia T, Zhang S, Wang AG
Journal of advanced research 2024 Nov;65:197-210
Journal of advanced research 2024 Nov;65:197-210
Placenta-derived exosomes as carriers of non-coding RNAs in maternal circulation of patients with preeclampsia.
Yang Y, An R, Yuan Y, Chen Y, Zhao J, Zhu X, Ma Y
Biotechnology & genetic engineering reviews 2024 Nov;40(3):2683-2703
Biotechnology & genetic engineering reviews 2024 Nov;40(3):2683-2703
Study on the mechanism of arsenic-induced renal injury based on SWATH proteomics technology.
Chen X, Yan X, Tang X, Wang Y, Zhang X, Cao X, Ran X, Ma G, Hu T, Qureshi A, Luo P, Shen L
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 May;83:127390
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 May;83:127390
Complement C1q is involved in the activation of membrane attack complexes, regulation of bacterial infectious inflammation, and apoptosis through overexpression in primary cells of silver pomfret (Pampus argenteus) in vitro.
Li Y, Hu J, Zhang Y, Yan K, Wang X, Zhou S, Xu S, Yan X, Wang Y
International journal of biological macromolecules 2024 May;268(Pt 1):131863
International journal of biological macromolecules 2024 May;268(Pt 1):131863
Betulinic acid inhibits the proliferation of human laryngeal carcinoma cells through reactive oxygen species-mediate mitochondrial apoptotic pathway.
Zhang H, Zhou M, Ye C, Qin J, Lu X, Wang C, Wang X, Jin X
Toxicology in vitro : an international journal published in association with BIBRA 2024 Mar;95:105756
Toxicology in vitro : an international journal published in association with BIBRA 2024 Mar;95:105756
Quercetin alleviates the toxicity of difenoconazole to the respiratory system of carp by reducing ROS accumulation and maintaining mitochondrial dynamic balance.
Ji X, Guo J, Ma Y, Zhang S, Yang Z, Li Y, Ping K, Xin Y, Dong Z
Toxicology and applied pharmacology 2024 Mar;484:116860
Toxicology and applied pharmacology 2024 Mar;484:116860
Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons.
Atarashi N, Morishita M, Matsuda S
The Journal of biological chemistry 2024 Mar;300(3):105744
The Journal of biological chemistry 2024 Mar;300(3):105744
T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway.
Yu FF, Yu SY, Sun L, Zuo J, Luo KT, Wang M, Fu XL, Zhang F, Huang H, Zhou GY, Wang YJ, Ba Y
Journal of hazardous materials 2024 Mar 5;465:133090
Journal of hazardous materials 2024 Mar 5;465:133090
Metformin switches cell death modes to soothe the apical periodontitis via ZBP1.
Liu H, Liu YX, Fan W, Fan B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23549
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23549
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Wang R, Min Q, Guo Y, Zhou Y, Zhang X, Wang D, Gao Y, Wei L
iScience 2024 Mar 15;27(3):109246
iScience 2024 Mar 15;27(3):109246
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells.
Zhang JW, Huang LY, Li YN, Tian Y, Yu J, Wang XF
World journal of gastrointestinal oncology 2024 Mar 15;16(3):991-1005
World journal of gastrointestinal oncology 2024 Mar 15;16(3):991-1005
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261
Journal of translational medicine 2024 Mar 10;22(1):261
Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis.
Zhang Z, Zhao Q, Wang Z, Xu F, Liu Y, Guo Y, Li C, Liu T, Zhao Y, Tang X, Zhang J
Hepatology communications 2024 Mar 1;8(3)
Hepatology communications 2024 Mar 1;8(3)
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
Gao M, Shen H, Li Q, Gu X, Jia T, Wang Y
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Shi Z, Yang F, Hu Y, Pang Q, Shi L, Du T, Cao Y, Song B, Yu X, Cao Z, Ye Z, Liu C, Yu R, Chen X, Zhu Y, Pang Q
Carbohydrate polymers 2024 Mar 1;327:121666
Carbohydrate polymers 2024 Mar 1;327:121666
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Gu M, Li C, Deng Q, Chen X, Lei R
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Li D, Mo R, Li X, Cheng R, Xie J, Li H, Yang Y, Li S, Li H, Yan Z, Wei S, Idris A, Li X, Feng R
mSphere 2024 Jun 25;9(6):e0023624
mSphere 2024 Jun 25;9(6):e0023624
Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics.
Peng X, Zhao H, Ye L, Hou F, Yi Z, Ren Y, Lu L, Chen F, Lv J, Wang Y, Cai H, Zheng X, Yang Q, Chen T
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Jul 15;30(14):3059-3072
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Jul 15;30(14):3059-3072
PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release.
Li JY, Sun XA, Wang X, Yang NH, Xie HY, Guo HJ, Lu L, Xie X, Zhou L, Liu J, Zhang W, Lu LM
Acta pharmacologica Sinica 2024 Jan;45(1):125-136
Acta pharmacologica Sinica 2024 Jan;45(1):125-136
FUNDC1-induced mitophagy protects spinal cord neurons against ischemic injury.
Chen D, Zhou L, Chen G, Lin T, Lin J, Zhao X, Li W, Guo S, Wu R, Wang Z, Liu W
Cell death discovery 2024 Jan 5;10(1):4
Cell death discovery 2024 Jan 5;10(1):4
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Li Y, Li L, Xiong W, Duan X, Xi H
Theriogenology 2024 Jan 15;214:192-200
Theriogenology 2024 Jan 15;214:192-200
GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis.
Zhao Q, Yu M, Li J, Guo Y, Wang Z, Hu K, Xu F, Liu Y, Li L, Wan D, Zhao Y, Shang J, Zhang J
Discover oncology 2024 Jan 12;15(1):8
Discover oncology 2024 Jan 12;15(1):8
Gentiopicroside inhibits the progression of gastric cancer through modulating EGFR/PI3K/AKT signaling pathway.
Chen Q, Zhang T, Li B, Zhu Z, Ma X, Zhang Y, Li L, Zhu J, Zhang G
European journal of medical research 2024 Jan 11;29(1):47
European journal of medical research 2024 Jan 11;29(1):47
MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes.
Li Y, Zhong G, Li L, Li T, Li H, Li Y, Zhang H, Pan J, Hu L, Liao J, Yu W, Tang Z
The Science of the total environment 2024 Jan 1;906:167825
The Science of the total environment 2024 Jan 1;906:167825
Cold atmospheric plasma stabilizes mismatch repair for effective, uniform treatment of diverse colorectal cancer cell types.
He Y, Lu F, Jiang C, Gong F, Wu Z, Ostrikov K
Scientific reports 2024 Feb 13;14(1):3599
Scientific reports 2024 Feb 13;14(1):3599
Nanopore-related cellular death through cytoskeleton depolymerization by drug-induced ROS.
Zhang Y, Xu R, Wu J, Zhang Z, Wang Y, Yang H, Zhang S
Talanta 2024 Feb 1;268(Pt 2):125355
Talanta 2024 Feb 1;268(Pt 2):125355
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Gao C, Shang J, Sun Z, Xia M, Gao D, Sun R, Li W, Wang F, Zhang J
Molecular neurobiology 2024 Aug;61(8):5047-5070
Molecular neurobiology 2024 Aug;61(8):5047-5070
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
Zhu G, Li Y, Gao H, Li X, Fan H, Fan L
Journal of cardiovascular translational research 2024 Aug;17(4):782-794
Journal of cardiovascular translational research 2024 Aug;17(4):782-794
Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats.
Nie QY, Yang GM, Zhang P, Dong WJ, Jing D, Hou ZP, Peng YX, Yu Y, Li LH, Hong SJ
Brain research 2024 Aug 15;1837:148973
Brain research 2024 Aug 15;1837:148973
Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.
Liu M, Lu J, Hu J, Chen Y, Deng X, Wang J, Zhang S, Guo J, Li W, Guan S
Journal of hazardous materials 2024 Apr 5;467:133719
Journal of hazardous materials 2024 Apr 5;467:133719
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
Cheng F, Zhang J, Yang P, Chen Z, Fu Y, Mi J, Xie X, Liu S, Sheng Y
Heliyon 2024 Apr 30;10(8):e29162
Heliyon 2024 Apr 30;10(8):e29162
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Zhang H, Wang H, Hu Y, Gao Y, Chen J, Meng Y, Qiu Y, Hu R, Liao P, Li M, He Y, Liang Z, Xie X, Li Y
Cancer letters 2024 Apr 28;588:216802
Cancer letters 2024 Apr 28;588:216802
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
He Y, Jiang S, Cui Y, Liang J, Zhong Y, Sun Y, Moran MF, Huang Z, He G, Mao X
Cancer letters 2024 Apr 28;588:216797
Cancer letters 2024 Apr 28;588:216797
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
Wang X, Fu Y, Yang X, Chen Y, Zeng N, Hu S, Ouyang S, Pan X, Wu S
Scientific reports 2024 Apr 27;14(1):9723
Scientific reports 2024 Apr 27;14(1):9723
The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion.
Wang X, Hu B, Zhang H, Zhou S, Wu W, Tan Z, Sun M, Kang Q
Biochemical and biophysical research communications 2024 Apr 23;705:149722
Biochemical and biophysical research communications 2024 Apr 23;705:149722
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Wang L, Wang B, Zhang X, Yang Z, Zhang X, Gong H, Song Y, Zhang K, Sun M
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma.
Luo P, An Y, He J, Xing X, Zhang Q, Liu X, Chen Y, Yuan H, Chen J, Wong YK, Huang J, Gong Z, Du Q, Xiao W, Wang J
Cancer letters 2024 Apr 10;587:216621
Cancer letters 2024 Apr 10;587:216621
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Zhang T, Liu MQ, Xie GS, Wu DM, Luo PW, Liu T, Deng SH, Wang YY, He S, Zhou Y, Zhou J, Xu Y
Journal of Cancer 2023;14(8):1350-1361
Journal of Cancer 2023;14(8):1350-1361
Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjögren's syndrome.
Zong Y, Yang Y, Zhao J, Li L, Luo D, Hu J, Gao Y, Wei L, Li N, Jiang L
Frontiers in immunology 2023;14:1292146
Frontiers in immunology 2023;14:1292146
Exercise prevents fatal stress-induced myocardial injury in obese mice.
Dun Y, Hu Z, You B, Du Y, Zeng L, Zhao Y, Liu Y, Wu S, Cui N, Yang F, Liu S
Frontiers in endocrinology 2023;14:1223423
Frontiers in endocrinology 2023;14:1223423
E. coli Nissle 1917 ameliorates mitochondrial injury of granulosa cells in polycystic ovary syndrome through promoting gut immune factor IL-22 via gut microbiota and microbial metabolism.
Luo M, Chen Y, Pan X, Chen H, Fan L, Wen Y
Frontiers in immunology 2023;14:1137089
Frontiers in immunology 2023;14:1137089
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
Yu B, Jin L, Yao X, Zhang Y, Zhang G, Wang F, Su X, Fang Q, Xiao L, Yang Y, Jiang LH, Chen J, Yang W, Lin W, Han F
Theranostics 2023;13(13):4356-4375
Theranostics 2023;13(13):4356-4375
Electroacupuncture preconditioning protects against myocardial ischemia-reperfusion injury by modulating dynamic inflammatory response.
Bai H, Xu SL, Shi JJ, Ding YP, Liu QQ, Jiang CH, He LL, Zhang HR, Lu SF, Gu YH
Heliyon 2023 Sep;9(9):e19396
Heliyon 2023 Sep;9(9):e19396
Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta(2) C Modified with Chondroitin Sulfate (TACS).
Song X, Huang Q, Yang Y, Ma L, Liu W, Ou C, Chen Q, Zhao T, Xiao Z, Wang M, Jiang Y, Yang Y, Zhang J, Nan Y, Wu W, Ai K
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(36):e2301585
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(36):e2301585
Human placenta-derived mesenchymal stem cell administration protects against acute lung injury in a mouse model.
Fang J, Wei H, Wang H, Wang J, Liu H, Chen Y, Chen L, Lu L, Zhang Q, Pan R, Cui E, Luo X
Journal of cellular biochemistry 2023 Sep;124(9):1249-1258
Journal of cellular biochemistry 2023 Sep;124(9):1249-1258
Osteogenic microenvironment affects palatal development through glycolysis.
Peng X, Chen J, Wang Y, Wang X, Zhao X, Zheng X, Wang Z, Yuan D, Du J
Differentiation; research in biological diversity 2023 Sep-Oct;133:1-11
Differentiation; research in biological diversity 2023 Sep-Oct;133:1-11
A Terphenyllin Derivative CHNQD-00824 from the Marine Compound Library Induced DNA Damage as a Potential Anticancer Agent.
Cao XZ, Zhang BQ, Wang CF, Yin JN, Haider W, Said G, Wei MY, Lu L
Marine drugs 2023 Sep 27;21(10)
Marine drugs 2023 Sep 27;21(10)
Bilobalide Induces Apoptosis in 3T3-L1 Mature Adipocytes through ROS-Mediated Mitochondria Pathway.
Bu S, Xiong A, Yang Z, Aissa-Brahim F, Chen Y, Zhang Y, Zhou X, Cao F
Molecules (Basel, Switzerland) 2023 Sep 2;28(17)
Molecules (Basel, Switzerland) 2023 Sep 2;28(17)
Stereospecificity of Ginsenoside AD-1 and AD-2 Showed Anticancer Activity via Inducing Mitochondrial Dysfunction and Reactive Oxygen Species Mediate Cell Apoptosis.
Wang X, Ding M, Zhao H, Zhou M, Lu X, Sun Y, Zhang Q, Zhao Y, Wang R
Molecules (Basel, Switzerland) 2023 Sep 19;28(18)
Molecules (Basel, Switzerland) 2023 Sep 19;28(18)
Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway.
Lan X, Lu M, Fang X, Cao Y, Sun M, Shan M, Gao W, Wang Y, Yu W, Luo H
Molecules (Basel, Switzerland) 2023 Sep 15;28(18)
Molecules (Basel, Switzerland) 2023 Sep 15;28(18)
Long-term iTBS Improves Neural Functional Recovery by Reducing the Inflammatory Response and Inhibiting Neuronal Apoptosis Via miR-34c-5p/p53/Bax Signaling Pathway in Cerebral Ischemic Rats.
Hu S, Wang X, Yang X, Ouyang S, Pan X, Fu Y, Wu S
Neuroscience 2023 Sep 1;527:37-51
Neuroscience 2023 Sep 1;527:37-51
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Deng H, Jiang J, Shu J, Huang M, Zhang QL, Wu LJ, Sun WK
Inflammation 2023 Oct;46(5):1981-1996
Inflammation 2023 Oct;46(5):1981-1996
Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats.
You M, Li S, Yan S, Yao D, Wang T, Wang Y
Environment international 2023 Oct;180:108228
Environment international 2023 Oct;180:108228
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway.
Wang R, Dong S, Xia R, Sun M, Sun Y, Ren H, Zhang Y, Xia Z, Yao S, Wang T
European journal of pharmacology 2023 Oct 5;956:175985
European journal of pharmacology 2023 Oct 5;956:175985
Dietary Taurine Supplementation Improves the Meat Quality, Muscle Fiber Type, and Mitochondrial Function of Finishing Pigs.
An W, Huang Z, Mao Z, Qiao T, Jia G, Zhao H, Liu G, Chen X
Journal of agricultural and food chemistry 2023 Oct 18;71(41):15331-15340
Journal of agricultural and food chemistry 2023 Oct 18;71(41):15331-15340
Metformin alleviates cerebral ischemia/reperfusion injury aggravated by hyperglycemia via regulating AMPK/ULK1/PINK1/Parkin pathway-mediated mitophagy and apoptosis.
Guo Y, Jiang H, Wang M, Ma Y, Zhang J, Jing L
Chemico-biological interactions 2023 Oct 1;384:110723
Chemico-biological interactions 2023 Oct 1;384:110723
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp.
Li S, Xie J, Li K, Bai Y, Jiang Z, Xiong X
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109734
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109734
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.
Yamashita N, Withers H, Morimoto Y, Bhattacharya A, Haratake N, Daimon T, Fushimi A, Nakashoji A, Thorner AR, Isenhart E, Rosario S, Long MD, Kufe D
iScience 2023 Nov 17;26(11):108168
iScience 2023 Nov 17;26(11):108168
Methylcrotonyl-CoA carboxylase subunit 1 (MCCA) regulates multidrug resistance in multiple myeloma.
Feng Y, Huang J, Wang F, Lin Z, Luo H, Li Q, Wang X, Liu X, Zhai X, Gao Q, Li L, Zhang Y, Wen J, Zhang L, Niu T, Zheng Y
Life sciences 2023 Nov 15;333:122157
Life sciences 2023 Nov 15;333:122157
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.
Xu B, Zhou Z, Fang J, Wang J, Tao K, Liu J, Liu S
Free radical biology & medicine 2023 Nov 1;208:319-333
Free radical biology & medicine 2023 Nov 1;208:319-333
Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes.
Zhang H, Xiang X, Zhou B, Chen J, Sun Y, Zhang S, Li A, Li J
Journal of biochemical and molecular toxicology 2023 May;37(5):e23306
Journal of biochemical and molecular toxicology 2023 May;37(5):e23306
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication.
Fu J, Liu G, Zhang X, Lei X, Liu Q, Qian K, Tong Q, Qin W, Li Z, Cao Z, Zhang J, Liu C, Wang Z, Liu Z, Liang XM, Yamamoto H, Xu X
Cancer gene therapy 2023 May;30(5):738-751
Cancer gene therapy 2023 May;30(5):738-751
Oral Metal-Free Melanin Nanozymes for Natural and Durable Targeted Treatment of Inflammatory Bowel Disease (IBD).
Huang Q, Yang Y, Zhu Y, Chen Q, Zhao T, Xiao Z, Wang M, Song X, Jiang Y, Yang Y, Zhang J, Xiao Y, Nan Y, Wu W, Ai K
Small (Weinheim an der Bergstrasse, Germany) 2023 May;19(19):e2207350
Small (Weinheim an der Bergstrasse, Germany) 2023 May;19(19):e2207350
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.
Yang C, Wang ZQ, Zhang ZC, Lou G, Jin WL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529
SAR-guided development of indole-matrine hybrids as potential anticancer agents via mitochondrial stress/cytochrome c/caspase 3 signaling pathway.
Li L, Li J, Ma L, Shang H, Zou Z
Bioorganic chemistry 2023 May;134:106341
Bioorganic chemistry 2023 May;134:106341
Unraveling the potential of senescence-related genes in guiding clinical therapy of lung adenocarcinoma patients.
Liu C, Wei X
Functional & integrative genomics 2023 May 29;23(2):188
Functional & integrative genomics 2023 May 29;23(2):188
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Wang Y, Miao Z, Xu C, Cai Y, Yang Y, Hu Y, Zhao M, Shao Y, Li Z, Chen J, Chen S, Wang L
Cell death & disease 2023 May 13;14(5):325
Cell death & disease 2023 May 13;14(5):325
Cytotoxic steroidal glycosides from the rhizomes of Paris polyphylla var. yunnanensis.
Liu Y, Liu MY, Bi LL, Tian YY, Qiu PC, Qian XY, Wang MC, Tang HF, Lu YY, Zhang BL
Phytochemistry 2023 Mar;207:113577
Phytochemistry 2023 Mar;207:113577
Sirt3-dependent regulation of mitochondrial oxidative stress and apoptosis contributes to the dysfunction of pancreatic islets after severe burns.
Liu X, Xie X, Li D, Liu Z, Zhang B, Zang Y, Yuan H, Shen C
Free radical biology & medicine 2023 Mar;198:59-67
Free radical biology & medicine 2023 Mar;198:59-67
miR‑222-3p reduces neuronal cell apoptosis and alleviates spinal cord injury by inhibiting Bbc3 and Bim.
Zhang Q, Li G, Kong J, Dai J, Fan Z, Li J
Neuroscience research 2023 Mar;188:39-50
Neuroscience research 2023 Mar;188:39-50
Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.
Lin CL, Yu CI, Lee TH, Chuang JM, Han KF, Lin CS, Huang WP, Chen JY, Chen CY, Lin MY, Lee CH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154655
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154655
PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.
Lin H, Han H, Yang M, Wen Z, Chen Q, Ma Y, Wang X, Wang C, Yin T, Wang X, Lu G, Chen H, Qi J, Yang Y
European journal of medicinal chemistry 2023 Mar 5;249:115166
European journal of medicinal chemistry 2023 Mar 5;249:115166
Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway.
Tian Y, Che H, Yang J, Jin Y, Yu H, Wang C, Fu Y, Li N, Zhang J
Toxins 2023 Mar 21;15(3)
Toxins 2023 Mar 21;15(3)
Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes.
Li J, Hui Y, Xu Z, Tan J, Yin K, Kuang L, Tang Y, Wei J, Zhong Q, Zheng T
iScience 2023 Mar 17;26(3):106271
iScience 2023 Mar 17;26(3):106271
HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome.
Li J, Lin Q, Shao X, Li S, Zhu X, Wu J, Mou S, Gu L, Wang Q, Zhang M, Zhang K, Lu J, Ni Z
Cell death & disease 2023 Mar 17;14(3):200
Cell death & disease 2023 Mar 17;14(3):200
Mir-153-3p Modulates the Breast Cancer Cells' Chemosensitivity to Doxorubicin by Targeting KIF20A.
Rahman KU, Yang S, Azam N, Yuan Z, Yu J, Zhao C, Feng B
Cancers 2023 Mar 11;15(6)
Cancers 2023 Mar 11;15(6)
Novel antioxidant peptides from MFGM protein Hydrolysates: Separation, identification and effects on Dexamethasone-induced mitochondrial dysfunction.
Li H, Guan K, Liu M, Liu D, Wang W, Zhu A
Food chemistry 2023 Mar 1;403:134473
Food chemistry 2023 Mar 1;403:134473
Exploring the potential of ginseng glycoprotein to improve learning and memory in mice via Notch signaling pathway and structural analysis using multi-information fusion based on liquid chromatography-mass spectrometry.
Fang X, Zhang X, Zhang Y, Zhang X, Shan M, Guan S, Qiu Z, Zhu D, Luo H
Journal of ethnopharmacology 2023 Mar 1;303:115978
Journal of ethnopharmacology 2023 Mar 1;303:115978
Aidi injection enhances the anti-tumor impact of doxorubicin in H22 tumor-containing mice.
Lu Y, Zhang S, Zhu X, Wang K, He Y, Liu C, Sun J, Pan J, Zheng L, Liu W, Li Y, Huang Y, Liu T
Journal of ethnopharmacology 2023 Mar 1;303:115968
Journal of ethnopharmacology 2023 Mar 1;303:115968
Toosendanin-induced apoptosis of CMT-U27 is mediated through the mitochondrial apoptotic pathway.
Yang Y, Mei C, Xian H, Zhang X, Li J, Liang ZX, Zhi Y, Ma Y, Wang HJ
Veterinary and comparative oncology 2023 Jun;21(2):315-326
Veterinary and comparative oncology 2023 Jun;21(2):315-326
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway.
Liu H, Xu L, Zhou L, Han W, Li Z, Liu C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113782
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113782
Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.
Liu H, Zhou Z, Deng H, Tian Z, Wu Z, Liu X, Ren Z, Jiang Z
European journal of pharmacology 2023 Jun 15;949:175735
European journal of pharmacology 2023 Jun 15;949:175735
Neuroprotective mechanisms of OXCT1 via the SIRT3-SOD2 pathway after traumatic brain injury.
Zhuang YS, Wang X, Gao SQ, Miao SH, Li T, Gao CC, Han YL, Qiu JY, Zhou ML, Wang HD
Brain research 2023 Jun 1;1808:148324
Brain research 2023 Jun 1;1808:148324
DR1-CSE/H(2)S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose.
Li H, Wei Y, Xi Y, Jiao L, Wen X, Wu R, Chang G, Sun F, Hao J
Acta cardiologica 2023 Jul;78(5):594-606
Acta cardiologica 2023 Jul;78(5):594-606
Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma.
Liu Z, Wang N, Meng Z, Lu S, Peng G
Toxicology 2023 Jul;493:153556
Toxicology 2023 Jul;493:153556
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.
Liang JP, He YM, Cui YL, Sun YN, He GS, Zhu ZG, Mao XL
Acta pharmacologica Sinica 2023 Jul;44(7):1464-1474
Acta pharmacologica Sinica 2023 Jul;44(7):1464-1474
Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
Fan L, Zhang X, Huang Y, Zhang B, Li W, Shi Q, Lin Y, Wu F
Phytotherapy research : PTR 2023 Jul;37(7):3025-3041
Phytotherapy research : PTR 2023 Jul;37(7):3025-3041
A mitochondria-targeting ROS-activated nanoprodrug for self-augmented antitumor oxidation therapy.
Zeng Z, Luo Y, Xu X, Shan T, Chen M, Huang Z, Huang Y, Zhao C
Journal of controlled release : official journal of the Controlled Release Society 2023 Jul;359:415-427
Journal of controlled release : official journal of the Controlled Release Society 2023 Jul;359:415-427
Liensinine, a alkaloid from lotus plumule, mitigates lipopolysaccharide-induced sepsis-associated encephalopathy through modulation of nuclear factor erythroid 2-related factor-mediated inflammatory biomarkers and mitochondria apoptosis.
Wang G, Sun Y, Yang Q, Dai D, Zhang L, Fan H, Zhang W, Dong J, Zhao P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113813
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113813
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Zhou W, Wang C, Zhang B, Gou S
European journal of pharmacology 2023 Jul 5;950:175751
European journal of pharmacology 2023 Jul 5;950:175751
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Zhou M, Kong B, Zhang X, Xiao K, Lu J, Li W, Li M, Li Z, Ji W, Hou J, Xu T
iScience 2023 Jul 21;26(7):107159
iScience 2023 Jul 21;26(7):107159
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
Liu WY, Li Y, Li Y, Xu LZ, Jia JP
Molecular neurobiology 2023 Jan;60(1):133-144
Molecular neurobiology 2023 Jan;60(1):133-144
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Hou S, Cheng Y, Wang Z, Xia L, Wang J, Wang H, Sun J, Ma J, Yan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Myeloid-derived suppressor cells ameliorate liver mitochondrial damage to protect against autoimmune hepatitis by releasing small extracellular vesicles.
Shen M, Fan X, Shen Y, Wang X, Wu R, Wang Y, Huang C, Zhao S, Zheng Y, Men R, Luo X, Yang L
International immunopharmacology 2023 Jan;114:109540
International immunopharmacology 2023 Jan;114:109540
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
Zhang Z, Pi R, Jiang Y, Ahmad M, Luo H, Luo J, Yang J, Sun B
Human & experimental toxicology 2023 Jan-Dec;42:9603271231172724
Human & experimental toxicology 2023 Jan-Dec;42:9603271231172724
The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest.
Zhao W, Zhang L, Zhang Y, Jiang Z, Lu H, Xie Y, Han W, Zhao W, He J, Shi Z, Yang H, Chen J, Chen S, Li Z, Mao J, Zhou L, Gao X, Li W, Tan G, Zhang B, Wang Z
Cell death & disease 2023 Jan 9;14(1):11
Cell death & disease 2023 Jan 9;14(1):11
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress.
Ma M, Luan X, Zheng H, Wang X, Wang S, Shen T, Ren D
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease.
Li X, Zhang Y, Xu L, Wang A, Zou Y, Li T, Huang L, Chen W, Liu S, Jiang K, Zhang X, Wang D, Zhang L, Zhang Z, Zhang Z, Chen X, Jia W, Zhao A, Yan X, Zhou H, Zhu L, Ma X, Ju Z, Jia W, Wang C, Loscalzo J, Yang Y, Zhao Y
Cell metabolism 2023 Jan 3;35(1):200-211.e9
Cell metabolism 2023 Jan 3;35(1):200-211.e9
Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway.
Cheng B, Chu X, Liu R, Ma X, Wang M, Zhang J, Jiao P, Gao Q, Ma W, Zhang Y, Zhao C, Zhou D, Xiao S
Molecular pharmaceutics 2023 Jan 2;20(1):701-710
Molecular pharmaceutics 2023 Jan 2;20(1):701-710
Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator.
Zhang Y, Pan Z, Chen C, Tan Y, Wang X, Wang L, Zhang L, Chen Y, He G
European journal of medicinal chemistry 2023 Jan 15;246:114970
European journal of medicinal chemistry 2023 Jan 15;246:114970
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
Mitochondrial targeting half-sandwich iridium(III) and ruthenium(II) dppf complexes and in vitro anticancer assay.
Liu J, Wu Y, Yang G, Liu Z, Liu X
Journal of inorganic biochemistry 2023 Feb;239:112069
Journal of inorganic biochemistry 2023 Feb;239:112069
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, Jin H, Chen S, Peng Y
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction.
Sun Q, Ma H, Zhang J, You B, Gong X, Zhou X, Chen J, Zhang G, Huang J, Huang Q, Yang Y, Ai K, Bai Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(5):e2204999
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(5):e2204999
Spleen Toxicity of Organophosphorus Flame Retardant TDCPP in Mice and the Related Mechanisms.
Cao L, Wei L, Du Q, Su Y, Ye S, Liu K
Toxics 2023 Feb 27;11(3)
Toxics 2023 Feb 27;11(3)
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells.
Zhang Y, Mao H, Li Y, Xiong Y, Liu X, Wang L, Chen Z
International journal of molecular sciences 2023 Feb 14;24(4)
International journal of molecular sciences 2023 Feb 14;24(4)
To explore the regulatory role of Wnt/P53/Caspase3 signal in mouse ovarian development based on LFQ proteomics.
Ma Y, Du C, Xie X, Zhang Y, Wang C, Xu J, Xia G, Yang Y
Journal of proteomics 2023 Feb 10;272:104772
Journal of proteomics 2023 Feb 10;272:104772
Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury.
Chen C, Fan P, Zhang L, Xue K, Hu J, Huang J, Lu W, Xu J, Xu S, Qiu G, Ran J, Gan S
Neuroscience 2023 Feb 1;510:95-108
Neuroscience 2023 Feb 1;510:95-108
Epothilone B inactivation of Sirtuin1 promotes mitochondrial reactive oxygen species to induce dysfunction and ferroptosis of Schwann cells.
Liang Z, Zhang N, Wang X, Zhang J, Li K, Lei T
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Feb 1;181:106350
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Feb 1;181:106350
Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT.
Kanno SI, Hara A
Toxicology in vitro : an international journal published in association with BIBRA 2023 Dec;93:105698
Toxicology in vitro : an international journal published in association with BIBRA 2023 Dec;93:105698
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells.
Huang J, Wei W, Kang F, Tan S, Li Y, Lu X, Wang N
Genes & genomics 2023 Dec;45(12):1575-1586
Genes & genomics 2023 Dec;45(12):1575-1586
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
Wang H, Yang G, Zhang X, Zhang H, Liu Y, Wang C, Miao L, Li Y, Huang Y, Teng H, Wang S, Cheng H, Zeng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
Yuan S, Che Y, Wang Z, Xing K, Xie X, Chen Y
Journal of translational medicine 2023 Dec 20;21(1):925
Journal of translational medicine 2023 Dec 20;21(1):925
The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis.
Renaud CCN, Trillet K, Jardine J, Merlet L, Renoult O, Laurent-Blond M, Catinaud Z, Pecqueur C, Gavard J, Bidère N
Communications biology 2023 Dec 15;6(1):1271
Communications biology 2023 Dec 15;6(1):1271
Cirsiliol induces autophagy and mitochondrial apoptosis through the AKT/FOXO1 axis and influences methotrexate resistance in osteosarcoma.
Luo M, Su Z, Gao H, Tan J, Liao R, Yang J, Lin L
Journal of translational medicine 2023 Dec 12;21(1):907
Journal of translational medicine 2023 Dec 12;21(1):907
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification.
Gao J, Su G, Chen W, Wu Q, Liu J, Liu J, Chai M, Dong Y, Wang H, Chen L, Zhang Z, Wang M
Clinical and experimental pharmacology & physiology 2023 Aug;50(8):647-663
Clinical and experimental pharmacology & physiology 2023 Aug;50(8):647-663
SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria.
Zong S, Wu Y, Li W, You Q, Peng Q, Wang C, Wan P, Bai T, Ma Y, Sun B, Qiao J
Virologica Sinica 2023 Aug;38(4):520-530
Virologica Sinica 2023 Aug;38(4):520-530
Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway.
Chen Y, Zhang Y, Wang X, Qiao S
Journal of biochemical and molecular toxicology 2023 Aug;37(8):e23387
Journal of biochemical and molecular toxicology 2023 Aug;37(8):e23387
Treatment with FAP-targeted zinc ferrite nanoparticles for rheumatoid arthritis by inducing endoplasmic reticulum stress and mitochondrial damage.
Qi W, Jin L, Wu C, Liao H, Zhang M, Zhu Z, Han W, Chen Q, Ding C
Materials today. Bio 2023 Aug;21:100702
Materials today. Bio 2023 Aug;21:100702
Difenoconazole disrupts carp intestinal physical barrier and causes inflammatory response via triggering oxidative stress and apoptosis.
Wu X, Han H, Xie K, He N, Yang Z, Jin X, Ma S, Dong J
Pesticide biochemistry and physiology 2023 Aug;194:105507
Pesticide biochemistry and physiology 2023 Aug;194:105507
Multi-Catcher Polymers Regulate the Nucleolin Cluster on the Cell Surface for Cancer Therapy.
Cheng F, Jiang Y, Kong B, Lin H, Shuai X, Hu P, Gao P, Zhan L, Huang C, Li C
Advanced healthcare materials 2023 Aug;12(21):e2300102
Advanced healthcare materials 2023 Aug;12(21):e2300102
The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.
Zhang X, Xiao Y, Huang Q
International journal of biological macromolecules 2023 Aug 30;247:125747
International journal of biological macromolecules 2023 Aug 30;247:125747
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.
Zheng Y, Zhan Y, Zhang Y, Zhang Y, Liu Y, Xie Y, Sun Y, Qian J, Ding Y, Ding Y, Fang Y
Cell death & disease 2023 Aug 1;14(8):488
Cell death & disease 2023 Aug 1;14(8):488
Inhibition of autophagic flux by the curcumin analog EF-24 and its antiproliferative effect on MCF-7 cancer cells.
Li J, Wang SH, Liu YT, Zhang Q, Zhou GZ
Journal of biochemical and molecular toxicology 2023 Apr;37(4):e23307
Journal of biochemical and molecular toxicology 2023 Apr;37(4):e23307
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Wang H, Zhou HC, Ren RL, Du SX, Guo ZK, Shen XH
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia.
Gohel D, Shukla S, Rajan WD, Wojtas B, Kaminska B, Singh R
Free radical biology & medicine 2023 Apr;199:26-33
Free radical biology & medicine 2023 Apr;199:26-33
Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole.
Feng H, Chen H, Qiang J, Xu B, Wu X, Pan E, Yang H, Li X, Zhang J, Dong J
Pesticide biochemistry and physiology 2023 Apr;191:105343
Pesticide biochemistry and physiology 2023 Apr;191:105343
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Zhong Y, Wang L, Jin R, Liu J, Luo R, Zhang Y, Zhu L, Peng X
Nutrients 2023 Apr 30;15(9)
Nutrients 2023 Apr 30;15(9)
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Ji W, Zhang L, Ma C, Xu X, Li S, Xia H, Zhou W, Liu X
Cell reports 2023 Apr 25;42(4):112327
Cell reports 2023 Apr 25;42(4):112327
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Li TY, Du Y, Wang MC, Liu K, Liu Y, Cao Y, Wang YY, Chen WW, Qian XY, Qiu PC, Tang HF, Lu YY
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
The Exploration of miRNAs From Porcine Fallopian Tube Stem Cells on Porcine Oocytes.
Fu TY, Wang SH, Lin TY, Shen PC, Chang SC, Lin YH, Chou CJ, Yu YH, Yang KT, Huang CW, Shaw SW, Peng SY
Frontiers in veterinary science 2022;9:869217
Frontiers in veterinary science 2022;9:869217
Methylcobalamin Alleviates Neuronal Apoptosis and Cognitive Decline Induced by PM2.5 Exposure in Mice.
Ji X, Li C, Zhu X, Yu W, Cai Y, Zhu X, Lu L, Qian Q, Hu Y, Zhu X, Wang H
Journal of Alzheimer's disease : JAD 2022;86(4):1783-1796
Journal of Alzheimer's disease : JAD 2022;86(4):1783-1796
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
Feng S, Wan S, Liu S, Wang W, Tang M, Bai L, Zhu Y
Oxidative medicine and cellular longevity 2022;2022:5501346
Oxidative medicine and cellular longevity 2022;2022:5501346
CORM-3 Attenuates Oxidative Stress-Induced Bone Loss via the Nrf2/HO-1 Pathway.
Jin C, Lin BH, Zheng G, Tan K, Liu GY, Yao Z, Xie J, Chen WK, Chen L, Xu TH, Huang CB, Wu ZY, Yang L
Oxidative medicine and cellular longevity 2022;2022:5098358
Oxidative medicine and cellular longevity 2022;2022:5098358
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Wang S, Tan J, Chen L, Wang J
Journal of oncology 2022;2022:2956888
Journal of oncology 2022;2022:2956888
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Li B, Lu ZY, Jiang SD, Jiang LS, Zheng XF
Oxidative medicine and cellular longevity 2022;2022:2912276
Oxidative medicine and cellular longevity 2022;2022:2912276
Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.
Jia C, Li X, Pan J, Ma H, Wu D, Lu H, Wang W, Zhang X, Yi X
Oxidative medicine and cellular longevity 2022;2022:1135827
Oxidative medicine and cellular longevity 2022;2022:1135827
Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.
Zhang Q, Luo P, Chen J, Yang C, Xia F, Zhang J, Tang H, Liu D, Gu L, Shi Q, He X, Yang T, Wang J
International journal of biological sciences 2022;18(5):2003-2017
International journal of biological sciences 2022;18(5):2003-2017
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729
Drug design, development and therapy 2022;16:1713-1729
Ras-related protein Rab-20 inhibition alleviates cerebral ischemia/reperfusion injury by inhibiting mitochondrial fission and dysfunction.
Guo J, Zhang L, Bu Y, Li W, Hu J, Li J
Frontiers in molecular neuroscience 2022;15:986710
Frontiers in molecular neuroscience 2022;15:986710
Cryptotanshinone alleviates myocardial ischemia and reperfusion injury in rats to mitigate ER stress-dependent apoptosis by modulating the JAK1/STAT3 axis.
Wang S, Sun L, Zhu Z, Liu J, Ge W, Li B, Wang B
American journal of translational research 2022;14(7):5024-5039
American journal of translational research 2022;14(7):5024-5039
GPR27 Regulates Hepatocellular Carcinoma Progression via MAPK/ERK Pathway.
Wang H, Du D, Huang J, Wang S, He X, Yuan S, Xiao J
Cancer management and research 2022;14:1165-1177
Cancer management and research 2022;14:1165-1177
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.
Bai Y, Chen J, Hu W, Wang L, Wu Y, Yu S
Frontiers in pharmacology 2022;13:847905
Frontiers in pharmacology 2022;13:847905
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice.
Zhao P, Li X, Yang Q, Lu Y, Wang G, Yang H, Dong J, Zhang H
Frontiers in pharmacology 2022;13:1038802
Frontiers in pharmacology 2022;13:1038802
Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis.
Dong Y, Lv D, Zhao Z, Xu Z, Hu Z, Tang B
Frontiers in bioengineering and biotechnology 2022;10:892015
Frontiers in bioengineering and biotechnology 2022;10:892015
Ultra-small molybdenum-based nanodots as an antioxidant platform for effective treatment of periodontal disease.
Chen L, Zhao T, Liu M, Chen Q, Yang Y, Zhang J, Wang S, Zhu X, Zhang H, Huang Q, Ai K
Frontiers in bioengineering and biotechnology 2022;10:1042010
Frontiers in bioengineering and biotechnology 2022;10:1042010
Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30.
Qin X, Wang R, Xu H, Tu L, Chen H, Li H, Liu N, Wang J, Li S, Yin F, Xu N, Li Z
Autophagy 2022 Sep;18(9):2178-2197
Autophagy 2022 Sep;18(9):2178-2197
Improvement of anticancer effect of berberine by salt formation modifications.
Xu F, Liu M, Liao Y, Zhou Y, Zhang P, Zeng Y, Liu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154314
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154314
Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer.
Lu J, Shuai B, Shou Z, Guo W, Zhou C, Ouyang X, Zhou H, Li J, Cui J, Jiang F, Jin KY, Sarapultsev A, Li F, Zhang G, Luo S, Hu D
Cancers 2022 Sep 24;14(19)
Cancers 2022 Sep 24;14(19)
FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.
Dang Y, He Q, Yang S, Sun H, Liu Y, Li W, Tang Y, Zheng Y, Wu T
Pharmaceuticals (Basel, Switzerland) 2022 Sep 22;15(10)
Pharmaceuticals (Basel, Switzerland) 2022 Sep 22;15(10)
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.
Lin Y, Zhang Q, Xie B, Jiang H, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways.
Zhang T, Dong Z, Liu F, Pan E, He N, Ma F, Wang G, Wang Y, Dong J
Ecotoxicology and environmental safety 2022 Sep 15;243:113961
Ecotoxicology and environmental safety 2022 Sep 15;243:113961
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
Chang X, Wang J, Bian J, Liu Z, Guo M, Li Z, Wu Y, Zhai X, Zuo D
Toxicology and applied pharmacology 2022 Sep 1;450:116156
Toxicology and applied pharmacology 2022 Sep 1;450:116156
Mammary Fibrosis Tendency and Mitochondrial Adaptability in Dairy Cows with Mastitis.
Kan X, Hu G, Liu Y, Xu P, Huang Y, Cai X, Guo W, Fu S, Liu J
Metabolites 2022 Oct 28;12(11)
Metabolites 2022 Oct 28;12(11)
Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy.
Fan H, Cui J, Liu F, Zhang W, Yang H, He N, Dong Z, Dong J
European journal of pharmacology 2022 Oct 15;933:175252
European journal of pharmacology 2022 Oct 15;933:175252
Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia.
Zhou W, Wang C, Liu Z, Gou S
Journal of medicinal chemistry 2022 Oct 13;65(19):13436-13451
Journal of medicinal chemistry 2022 Oct 13;65(19):13436-13451
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Liu F, Wang Y, Chen L, Bello BK, Zhang T, Yang H, Li X, Pan E, Feng H, Dong J
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells.
Deng L, Zhao M, Cui Y, Xia Q, Jiang L, Yin H, Zhao L
Drug and chemical toxicology 2022 Nov;45(6):2601-2612
Drug and chemical toxicology 2022 Nov;45(6):2601-2612
Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice.
Zhou Z, Wang M, Huang C, Li Y, Gao L, Zhu Y, Ying C, Zhou X
Brain research bulletin 2022 Nov;190:84-96
Brain research bulletin 2022 Nov;190:84-96
Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.
Zhong Y, Li Z, Jin R, Yao Y, He S, Lei M, Wang X, Shi C, Gao L, Peng X
Nutrients 2022 Nov 24;14(23)
Nutrients 2022 Nov 24;14(23)
Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells.
Pan Z, Chen Y, Pang H, Wang X, Zhang Y, Xie X, He G
European journal of medicinal chemistry 2022 Nov 15;242:114674
European journal of medicinal chemistry 2022 Nov 15;242:114674
Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle.
Huang S, Zheng X, Zhang X, Jin Z, Liu S, Fu L, Niu Y
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Nov 1;47(11):1062-1074
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Nov 1;47(11):1062-1074
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6
Molecular cell 2022 May 19;82(10):1821-1835.e6
Dietary lycopene supplementation improves meat quality, antioxidant capacity and skeletal muscle fiber type transformation in finishing pigs.
Wen W, Chen X, Huang Z, Chen D, Yu B, He J, Luo Y, Yan H, Chen H, Zheng P, Yu J
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Mar;8(1):256-264
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Mar;8(1):256-264
Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control.
Zhong Y, Liu J, Sun D, Guo T, Yao Y, Xia X, Shi C, Peng X
Food & function 2022 Mar 21;13(6):3660-3673
Food & function 2022 Mar 21;13(6):3660-3673
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
Guo H, Xiao Y, Yuan Z, Yang X, Chen J, Chen C, Wang M, Xie L, Chen Q, Tong Y, Zhang Q, Bai Y
Cell death discovery 2022 Mar 14;8(1):116
Cell death discovery 2022 Mar 14;8(1):116
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K
European journal of medicinal chemistry 2022 Jun 5;236:114313
European journal of medicinal chemistry 2022 Jun 5;236:114313
Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats.
Guo Y, Gan D, Hu F, Cheng Y, Yu J, Lei B, Shu Q, Gu R, Xu G
Biological research 2022 Jun 3;55(1):22
Biological research 2022 Jun 3;55(1):22
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Chen Z, Wang H, Hu B, Chen X, Zheng M, Liang L, Lyu J, Zeng Q
European journal of histochemistry : EJH 2022 Jun 21;66(3)
European journal of histochemistry : EJH 2022 Jun 21;66(3)
Dopamine 1 receptors inhibit apoptosis via activating CSE/H(2) S pathway in high glucose-induced vascular endothelial cells.
Li H, Wu R, Xi Y, Li H, Chang G, Sun F, Wei C, Jiao L, Wen X, Zhang G, Zaid A, Hao J
Cell biology international 2022 Jul;46(7):1098-1108
Cell biology international 2022 Jul;46(7):1098-1108
Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring.
Burmeister AR, Gordevicius J, Paul EN, Houck C, George S, Escobar Galvis ML, Sha Q, Brundin P, Pospisilik JA, Racicot K, Brundin L
Neurobiology of disease 2022 Jul;169:105720
Neurobiology of disease 2022 Jul;169:105720
Duck Tembusu virus infection induces mitochondrial-mediated and death receptor-mediated apoptosis in duck embryo fibroblasts.
Pan Y, Cai W, Cheng A, Wang M, Chen S, Huang J, Yang Q, Wu Y, Sun D, Mao S, Zhu D, Liu M, Zhao X, Zhang S, Gao Q, Ou X, Tian B, Yin Z, Jia R
Veterinary research 2022 Jul 7;53(1):53
Veterinary research 2022 Jul 7;53(1):53
Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in vivo.
Chen X, Zhang M, Xue Y, Liang D, An W, Jia G, Zhao H, Liu G, Huang Z
The Journal of nutritional biochemistry 2022 Jan;99:108859
The Journal of nutritional biochemistry 2022 Jan;99:108859
DR1 activation promotes vascular smooth muscle cell apoptosis via up-regulation of CSE/H(2) S pathway in diabetic mice.
Wen X, Xi Y, Zhang Y, Jiao L, Shi S, Bai S, Sun F, Chang G, Wu R, Hao J, Li H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22070
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22070
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Zhong Y, Luo R, Liu Q, Zhu J, Lei M, Liang X, Wang X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Protective effects of hydroxy-α-sanshool from the pericarp of Zanthoxylum bungeanum Maxim. On D-galactose/AlCl(3)-induced Alzheimer's disease-like mice via Nrf2/HO-1 signaling pathways.
Liu Y, Meng X, Sun L, Pei K, Chen L, Zhang S, Hu M
European journal of pharmacology 2022 Jan 5;914:174691
European journal of pharmacology 2022 Jan 5;914:174691
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L
International journal of molecular sciences 2022 Jan 25;23(3)
International journal of molecular sciences 2022 Jan 25;23(3)
PTX3 alleviates hard metal-induced acute lung injury through potentiating efferocytosis.
Yan W, Ma D, Liu Y, Sun W, Cheng D, Li G, Zhou S, Wang Y, Wang H, Ni C
Ecotoxicology and environmental safety 2022 Jan 15;230:113139
Ecotoxicology and environmental safety 2022 Jan 15;230:113139
TERT Promoter Revertant Mutation Inhibits Melanoma Growth through Intrinsic Apoptosis.
Wang Y, Chen Y, Li C, Xiao Z, Yuan H, Zhang Y, Pang D, Tang X, Li M, Ouyang H
Biology 2022 Jan 14;11(1)
Biology 2022 Jan 14;11(1)
Neuroprotective Effects of Tetrahydroxystilbene Glucoside against Rotenone-Induced Toxicity in PC12 Cells.
Fu R, Xing H, Wang X, Liu Y, Li B, Zhang L, Li Z, Duan D, Chen J
Biological & pharmaceutical bulletin 2022 Jan 1;45(1):143-149
Biological & pharmaceutical bulletin 2022 Jan 1;45(1):143-149
DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease.
Li X, Pan J, Li H, Li G, Liu B, Tang X, Liu X, He Z, Peng Z, Zhang H, Wang L, Li Y, Xiang X, Chai X, Yuan Y, Zheng P, Zhang D
EBioMedicine 2022 Feb;76:103859
EBioMedicine 2022 Feb;76:103859
Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells.
Sun L, Wang H, Yu S, Zhang L, Jiang J, Zhou Q
International journal of molecular medicine 2022 Feb;49(2)
International journal of molecular medicine 2022 Feb;49(2)
Resveratrol reduces DRP1-mediated mitochondrial dysfunction via the SIRT1-PGC1α signaling pathway in manganese-induced nerve damage in mice.
Lei MY, Cong L, Liu ZQ, Liu ZF, Ma Z, Liu K, Li J, Deng Y, Liu W, Xu B
Environmental toxicology 2022 Feb;37(2):282-298
Environmental toxicology 2022 Feb;37(2):282-298
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.
Ayesha M, Majid A, Zhao D, Greenaway FT, Yan N, Liu Q, Liu S, Sun MZ
Journal of advanced research 2022 Feb;36:147-161
Journal of advanced research 2022 Feb;36:147-161
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
Wang N, Huang R, Yang K, He Y, Gao Y, Dong D
Journal of cellular and molecular medicine 2022 Feb;26(3):893-912
Journal of cellular and molecular medicine 2022 Feb;26(3):893-912
HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway.
Feng L, Liang L, Zhang S, Yang J, Yue Y, Zhang X
Autophagy 2022 Feb;18(2):320-339
Autophagy 2022 Feb;18(2):320-339
Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer.
Chen L, Shi H, Wang X, Wang T, Wang Y, Wu Z, Zhang W, Chen H, Zhong M, Mao X, Shi X, Li Q
European journal of pharmacology 2022 Feb 5;916:174727
European journal of pharmacology 2022 Feb 5;916:174727
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
Liang JJ, Yu WL, Yang L, Xie BH, Qin KM, Yin YP, Yan JJ, Gong S, Liu TY, Zhou HB, Hong K
European journal of medicinal chemistry 2022 Feb 5;229:114081
European journal of medicinal chemistry 2022 Feb 5;229:114081
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Wang Q, Chen W, Zhang B, Gao Z, Zhang Q, Deng H, Han L, Shen XL
Chemico-biological interactions 2022 Feb 25;354:109844
Chemico-biological interactions 2022 Feb 25;354:109844
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L
Cell 2022 Feb 17;185(4):712-728.e14
Cell 2022 Feb 17;185(4):712-728.e14
Prenatal exposure to environmentally relevant levels of PBDE-99 leads to testicular dysgenesis with steroidogenesis disorders.
Zhao T, Tang X, Li D, Zhao J, Zhou R, Shu F, Jia W, Fu W, Xia H, Liu G
Journal of hazardous materials 2022 Feb 15;424(Pt B):127547
Journal of hazardous materials 2022 Feb 15;424(Pt B):127547
Resolvin D1 attenuates sepsis induced acute kidney injury targeting mitochondria and NF-κB signaling pathway.
Wang L, Li J, Liao R, Li Y, Jiang L, Zhang Z, Geng J, Fu P, Su B, Zhao Y
Heliyon 2022 Dec;8(12):e12269
Heliyon 2022 Dec;8(12):e12269
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.
Lu QJ, Li JY, Lin HX, Cai YS, Liu CS, Fu LP, Liu G, Yuan LX
Pharmaceutical biology 2022 Dec;60(1):1606-1615
Pharmaceutical biology 2022 Dec;60(1):1606-1615
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
Zhang Q, Gao Y, Zhang Y, Jing M, Wang D, Wang Y, Khattak S, Qi H, Cai C, Zhang J, Ngowi EE, Khan NH, Li T, Ji A, Jiang Q, Ji X, Li Y, Wu D
Oncogene 2022 Dec;41(49):5238-5252
Oncogene 2022 Dec;41(49):5238-5252
Sevelamer arsenite nanoparticle as a Pi-responsive drug carrier and embolic agent for chemoembolization.
Bi QC, Tang JJ, Zhao J, Lv YF, Deng ZQ, Chen H, Xu YH, Xie CS, Liang QR, Luo RG, Tang Q
Drug delivery 2022 Dec;29(1):1447-1456
Drug delivery 2022 Dec;29(1):1447-1456
Nickel nanoparticles exert cytotoxic effects on trophoblast HTR-8/SVneo cells possibly via Nrf2/MAPK/caspase 3 pathway.
Li T, Li Z, Fu J, Tang C, Liu L, Xu J, Zhao J, Li Z
Environmental research 2022 Dec;215(Pt 2):114336
Environmental research 2022 Dec;215(Pt 2):114336
Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES.
Fu Z, Du H, Meng S, Yao M, Zhao P, Li X, Zheng X, Yuan Z, Yang H, Cai K, Dai L
Materials today. Bio 2022 Dec;16:100449
Materials today. Bio 2022 Dec;16:100449
Exogenous hydrogen sulfide inhibits the senescence of cardiomyocytes through modulating mitophagy in rats.
Hao J, Xi Y, Jiao L, Wen X, Wu R, Chang G, Sun F, Wei C, Li H
Cellular signalling 2022 Dec;100:110465
Cellular signalling 2022 Dec;100:110465
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Fu J, Yu S, Zhao X, Zhang C, Shen L, Liu Y, Yu H
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function.
Li J, Bu Y, Li B, Zhang H, Guo J, Hu J, Zhang Y
Journal of molecular histology 2022 Aug;53(4):713-727
Journal of molecular histology 2022 Aug;53(4):713-727
Effect of low energy shock wave on testicular microenvironment homeostasis in rats.
Xing J, Yu G, Xiang Y, Xu H, Liu Z, Bai Z
Ecotoxicology and environmental safety 2022 Aug;241:113710
Ecotoxicology and environmental safety 2022 Aug;241:113710
Cyclometalated iridium(III) dithioformic acid complexes as mitochondria-targeted imaging and anticancer agents.
Wu Y, Liu J, Shao M, Zhang P, Song S, Yang G, Liu X, Liu Z
Journal of inorganic biochemistry 2022 Aug;233:111855
Journal of inorganic biochemistry 2022 Aug;233:111855
Design, synthesis, and in vitro protective effect evaluation of α-carboline derivatives against H(2)O(2)-induced cardiomyocyte injury.
Zhang RH, Yang D, Liao XM, Zhang H, Chen GQ, Zhang WL, Wang YC, Wang C, Liao SG, Zhou M, Wang YL, Li YJ
European journal of medicinal chemistry 2022 Aug 5;238:114469
European journal of medicinal chemistry 2022 Aug 5;238:114469
Direct Analysis of Mitochondrial Damage Caused by Misfolded/Destabilized Proteins.
Aklima J, Onchaiya S, Saotome T, Velmurugan P, Motoichi T, Naima J, Kuroda Y, Ohta Y
International journal of molecular sciences 2022 Aug 31;23(17)
International journal of molecular sciences 2022 Aug 31;23(17)
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels.
Han Y, Li C, Zhang P, Yang X, Min J, Wu Q, Xie Y, Jin D, Wang Z, Shao F, Quan H
European journal of pharmacology 2022 Apr 5;920:174811
European journal of pharmacology 2022 Apr 5;920:174811
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.
Shang Y, Wang Q, Li J, Liu H, Zhao Q, Huang X, Dong H, Chen W, Gui R, Nie X
Frontiers in chemistry 2021;9:522708
Frontiers in chemistry 2021;9:522708
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.
Cai Y, Du Q, Deng TH, Shen BB, Peng YM, Zeng PH, Yu SR
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9922059
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9922059
Inhibition of α-Synuclein Accumulation Improves Neuronal Apoptosis and Delayed Postoperative Cognitive Recovery in Aged Mice.
Li Y, Yuan Y, Li Y, Han D, Liu T, Yang N, Mi X, Hong J, Liu K, Song Y, He J, Zhou Y, Han Y, Shi C, Yu S, Zou P, Guo X, Li Z
Oxidative medicine and cellular longevity 2021;2021:5572899
Oxidative medicine and cellular longevity 2021;2021:5572899
Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice.
Yu Y, Yang J, Luan F, Gu G, Zhao R, Wang Q, Dong Z, Tang J, Wang W, Sun J, Lv P, Zhang H, Wang C
Frontiers in cellular neuroscience 2021;15:658586
Frontiers in cellular neuroscience 2021;15:658586
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo.
Ding L, Ren C, Yang L, Wu Z, Li F, Jiang D, Zhu Y, Lu J
Drug design, development and therapy 2021;15:1797-1810
Drug design, development and therapy 2021;15:1797-1810
High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury - A Potential Mechanism for Obstructive Sleep Apnea with Obesity.
Chen Q, Han X, Chen M, Zhao B, Sun B, Sun L, Zhang W, Yu L, Liu Y
Nature and science of sleep 2021;13:2203-2219
Nature and science of sleep 2021;13:2203-2219
Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis.
Yin Z, Geng X, Zhang Z, Wang Y, Gao X
Frontiers in pharmacology 2021;12:746711
Frontiers in pharmacology 2021;12:746711
Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.
Xu L, Xu C, Liu X, Li X, Li T, Yu X, Xue M, Yang J, Kosmas CE, Moris D, Sanchis-Gomar F, Yoshida N, Berger NA, Aronow WS, Sun B, Chen L
Frontiers in physiology 2021;12:745058
Frontiers in physiology 2021;12:745058
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.
Zhang L, Zhang Y, Zhu M, Pei L, Deng F, Chen J, Zhang S, Cong Z, Du W, Xiao X
Frontiers in pharmacology 2021;12:590602
Frontiers in pharmacology 2021;12:590602
BLM interaction with EZH2 regulates MDM2 expression and is a poor prognostic biomarker for prostate cancer.
Ruan Y, Xu H, Ji X, Zhao J
American journal of cancer research 2021;11(4):1347-1368
American journal of cancer research 2021;11(4):1347-1368
Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin.
Zhang L, Fu R, Duan D, Li Z, Li B, Ming Y, Li L, Ni R, Chen J
Frontiers in oncology 2021;11:656184
Frontiers in oncology 2021;11:656184
PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma.
Wang B, Yin X, Gan W, Pan F, Li S, Xiang Z, Han X, Li D
Autophagy 2021 Sep;17(9):2475-2493
Autophagy 2021 Sep;17(9):2475-2493
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Shopit A, Li X, Wang S, Awsh M, Safi M, Chu P, Jia J, Al-Radhi M, Baldi S, Wang F, Fang J, Peng J, Ma X, Tang Z, Shu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Design and Synthesis of Novel Betulin Derivatives Containing Thio-/Semicarbazone Moieties as Apoptotic Inducers through Mitochindria-Related Pathways.
Wang J, Wu J, Han Y, Zhang J, Lin Y, Wang H, Wang J, Liu J, Bu M
Molecules (Basel, Switzerland) 2021 Oct 21;26(21)
Molecules (Basel, Switzerland) 2021 Oct 21;26(21)
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Ma Y, Li S, Ye S, Tang S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653
Chemico-biological interactions 2021 Oct 1;348:109653
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.
Zhao L, Zhou N, Zhang H, Pan F, Ai X, Wang Y, Hao S, Wang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112582
Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.
Xi H, Ren F, Li Y, Du Y, Wang L, Hu J
Biology of reproduction 2021 Nov 15;105(5):1344-1354
Biology of reproduction 2021 Nov 15;105(5):1344-1354
Alantolactone suppresses the metastatic phenotype and induces the apoptosis of glioblastoma cells by targeting LIMK kinase activity and activating the cofilin/G‑actin signaling cascade.
Wang X, Zou S, Ren T, Zhao LJ, Yu LF, Li XY, Yan X, Zhang LJ
International journal of molecular medicine 2021 May;47(5)
International journal of molecular medicine 2021 May;47(5)
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
Zhang L, Wang YN, Ju JM, Shabanova A, Li Y, Fang RN, Sun JB, Guo YY, Jin TZ, Liu YY, Li TY, Shan HL, Liang HH, Yang BF
Acta pharmacologica Sinica 2021 May;42(5):691-700
Acta pharmacologica Sinica 2021 May;42(5):691-700
Nicotinamide ameliorates energy deficiency and improves retinal function in Cav-1(-/-) mice.
Tang Y, Fang W, Xiao Z, Song M, Zhuang D, Han B, Wu J, Sun X
Journal of neurochemistry 2021 May;157(3):550-560
Journal of neurochemistry 2021 May;157(3):550-560
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Tao Y, Zhang J, Chen L, Liu X, Yao M, Zhang H
Cell death & disease 2021 May 18;12(6):510
Cell death & disease 2021 May 18;12(6):510
Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats.
Li SY, Wang CY, Zhao JJ, Long CY, Xiao YX, Tang XB, Yuan ZW, Bai YZ
Experimental cell research 2021 May 15;402(2):112574
Experimental cell research 2021 May 15;402(2):112574
Scutellarin ameliorates high glucose-induced vascular endothelial cells injury by activating PINK1/Parkin-mediated mitophagy.
Xi J, Rong Y, Zhao Z, Huang Y, Wang P, Luan H, Xing Y, Li S, Liao J, Dai Y, Liang J, Wu F
Journal of ethnopharmacology 2021 May 10;271:113855
Journal of ethnopharmacology 2021 May 10;271:113855
Plumbagin, a Biomolecule with (Anti)Osteoclastic Properties.
Sultanli S, Ghumnani S, Ashma R, Kubatzky KF
International journal of molecular sciences 2021 Mar 9;22(5)
International journal of molecular sciences 2021 Mar 9;22(5)
FGF1(ΔHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Wang D, Yin Y, Wang S, Zhao T, Gong F, Zhao Y, Wang B, Huang Y, Cheng Z, Zhu G, Wang Z, Wang Y, Ren J, Liang G, Li X, Huang Z
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Thymoquinone improves testicular damage and sperm quality in experimentally varicocele-induced adolescent rats.
Gur FM, Timurkaan S, Taskin E, Guven C, Gur HE, Senturk M, Dastan S, Nurdinov N, Unalan A, Cankut S, Tatyuz I
Andrologia 2021 Jun;53(5):e14033
Andrologia 2021 Jun;53(5):e14033
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Ma Y, Yang X, Han H, Wen Z, Yang M, Zhang Y, Fu J, Wang X, Yin T, Lu G, Qi J, Lin H, Wang X, Yang Y
Bioorganic chemistry 2021 Jun;111:104872
Bioorganic chemistry 2021 Jun;111:104872
Apoptotic caspases suppress Mycobacterium bovis-induced IFN-β production in murine macrophage.
Song Y, Dong Y, Liao Y, Liang Z, Yao J, Zhou X
The Journal of infection 2021 Jul;83(1):61-68
The Journal of infection 2021 Jul;83(1):61-68
Quantitative proteomics and bioinformatics analyses reveal the protective effects of cyanidin-3-O-glucoside and its metabolite protocatechuic acid against 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced cytotoxicity in HepG2 cells via apoptosis-related pathways.
Zhao L, Pan F, Zhou N, Zhang H, Wang Y, Hao S, Wang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Jul;153:112256
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Jul;153:112256
Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling.
Xu K, Shi H, Du Y, Ou J
3 Biotech 2021 Jul;11(7):323
3 Biotech 2021 Jul;11(7):323
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.
Li H, Dang C, Tai X, Xue L, Meng Y, Ma S, Zhang J
Scientific reports 2021 Jul 22;11(1):14985
Scientific reports 2021 Jul 22;11(1):14985
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer.
Lu Y, Bian D, Zhang X, Zhang H, Zhu Z
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Selenium Deficiency-Induced Damage and Altered Expression of Mitochondrial Biogenesis Markers in the Kidneys of Mice.
Lai H, Nie T, Zhang Y, Chen Y, Tao J, Lin T, Ge T, Li F, Li H
Biological trace element research 2021 Jan;199(1):185-196
Biological trace element research 2021 Jan;199(1):185-196
Remote Ischemic Postconditioning Inhibits Hippocampal Neuronal Apoptosis and Mitophagy After Cardiopulmonary Resuscitation in Rats.
Xie B, Gao X, Huang Y, Zhang Y, Zhu S
Shock (Augusta, Ga.) 2021 Jan 1;55(1):74-82
Shock (Augusta, Ga.) 2021 Jan 1;55(1):74-82
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.
Dai W, Wang M, Wang P, Wen J, Wang J, Cha S, Xiao X, He Y, Shu R, Bai D
International journal of molecular medicine 2021 Feb;47(2):607-620
International journal of molecular medicine 2021 Feb;47(2):607-620
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
Jhou AJ, Chang HC, Hung CC, Lin HC, Lee YC, Liu WT, Han KF, Lai YW, Lin MY, Lee CH
Biochemical pharmacology 2021 Feb;184:114403
Biochemical pharmacology 2021 Feb;184:114403
Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.
Zhang Q, Chen W, Zhang B, Li C, Zhang X, Wang Q, Wang Y, Zhou Q, Li X, Shen XL
Toxicology 2021 Feb 28;450:152681
Toxicology 2021 Feb 28;450:152681
Discovery of a PROTAC targeting ALK with in vivo activity.
Yan G, Zhong X, Yue L, Pu C, Shan H, Lan S, Zhou M, Hou X, Yang J, Li R
European journal of medicinal chemistry 2021 Feb 15;212:113150
European journal of medicinal chemistry 2021 Feb 15;212:113150
AK003290 Protects Myocardial Cells Against Apoptosis and Promotes Cardiac Function Recovery Via miR-539-3p/ErbB4 Axis in Ischemic-Reperfusion Injury.
Tang Y, Tang Y, Xiang Y, Yan J, Guo K
DNA and cell biology 2021 Dec;40(12):1528-1538
DNA and cell biology 2021 Dec;40(12):1528-1538
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice.
Xu Q, Fu Q, Li Z, Liu H, Wang Y, Lin X, He R, Zhang X, Ju Z, Campisi J, Kirkland JL, Sun Y
Nature metabolism 2021 Dec;3(12):1706-1726
Nature metabolism 2021 Dec;3(12):1706-1726
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines.
Chen CH, Chou YT, Yang YW, Lo KY
Apoptosis : an international journal on programmed cell death 2021 Dec;26(11-12):612-627
Apoptosis : an international journal on programmed cell death 2021 Dec;26(11-12):612-627
Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling.
Chen Y, Zhang H, Ji S, Jia P, Chen Y, Li Y, Wang T
Free radical biology & medicine 2021 Dec;177:1-14
Free radical biology & medicine 2021 Dec;177:1-14
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Khodayari N, Wang RL, Oshins R, Lu Y, Millett M, Aranyos AM, Mostofizadeh S, Scindia Y, Flagg TO, Brantly M
International journal of molecular sciences 2021 Dec 9;22(24)
International journal of molecular sciences 2021 Dec 9;22(24)
Lycopene increases the proportion of slow-twitch muscle fiber by AMPK signaling to improve muscle anti-fatigue ability.
Wen W, Chen X, Huang Z, Chen D, Yu B, He J, Zheng P, Luo Y, Yan H, Yu J
The Journal of nutritional biochemistry 2021 Aug;94:108750
The Journal of nutritional biochemistry 2021 Aug;94:108750
6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.
Pei XD, He ZL, Yao HL, Xiao JS, Li L, Gu JZ, Shi PZ, Wang JH, Jiang LH
European journal of nutrition 2021 Aug;60(5):2781-2793
European journal of nutrition 2021 Aug;60(5):2781-2793
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Ma X, Zhang J, Wu Z, Wang X
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.
Liu J, Liu L, Han YS, Yi J, Guo C, Zhao HQ, Ling J, Wang YH
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Xue W, Liu Q, Han J, Luo R, Feng J, Liu J, Guo T, Peng X, Hu T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Cypermethrin induces Sertoli cell apoptosis through mitochondrial pathway associated with calcium.
Wang HX, Zhang R, Li Z, Wang LS, Yu Y, Wang Q, Ding Z, Zhang JP, Zhang MR, Xu LC
Toxicology research 2021 Aug;10(4):742-750
Toxicology research 2021 Aug;10(4):742-750
Mitochondrial Voltage-Dependent Anion Channel 1-Hexokinase-II Complex-Targeted Strategy for Melanoma Inhibition Using Designed Multiblock Peptide Amphiphiles.
Zhang F, Angelova A, Garamus VM, Angelov B, Tu S, Kong L, Zhang X, Li N, Zou A
ACS applied materials & interfaces 2021 Aug 4;13(30):35281-35293
ACS applied materials & interfaces 2021 Aug 4;13(30):35281-35293
Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells.
Chen Y, Li P, Peng Y, Xie X, Zhang Y, Jiang Y, Li T, Qin X, Li S, Yang H, Wu C, Zheng C, Zhu J, You F, Liu Y
Free radical biology & medicine 2021 Aug 20;172:590-603
Free radical biology & medicine 2021 Aug 20;172:590-603
S-adenosylmethionine decarboxylase 1 and its related spermidine synthesis mediate PM(2.5) exposure-induced neuronal apoptosis.
Zhu X, Shou Y, Ji X, Hu Y, Wang H
Ecotoxicology and environmental safety 2021 Aug 19;224:112678
Ecotoxicology and environmental safety 2021 Aug 19;224:112678
Effects of apple polyphenols on myofiber-type transformation in longissimus dorsi muscle of finishing pigs.
Chen X, Jia G, Liu G, Zhao H, Huang Z
Animal biotechnology 2021 Apr;32(2):246-253
Animal biotechnology 2021 Apr;32(2):246-253
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
Xu WN, Yang RZ, Zheng HL, Jiang LS, Jiang SD
Frontiers in cell and developmental biology 2020;8:515051
Frontiers in cell and developmental biology 2020;8:515051
Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway.
Feng TY, Li Q, Ren F, Xi HM, Lv DL, Li Y, Hu JH
Oxidative medicine and cellular longevity 2020;2020:5954635
Oxidative medicine and cellular longevity 2020;2020:5954635
Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway.
Liu X, Bian H, Dou QL, Huang XW, Tao WY, Liu WH, Li N, Zhang WW
BioMed research international 2020;2020:1928410
BioMed research international 2020;2020:1928410
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416
International journal of biological sciences 2020;16(8):1403-1416
Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress.
Ji D, Zheng W, Huang P, Yao Y, Zhong X, Kang P, Wang Z, Shi G, Xu Y, Cui Y
OncoTargets and therapy 2020;13:7819-7837
OncoTargets and therapy 2020;13:7819-7837
L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson's Disease by Regulating Glutamine Metabolism.
Zhang Q, Gao Y, Zhang J, Li Y, Chen J, Huang R, Ma G, Wang L, Zhang Y, Nie K, Wang L
Frontiers in molecular neuroscience 2020;13:563054
Frontiers in molecular neuroscience 2020;13:563054
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, Liu H, Zhang Y, Zhang J, Gui R, Nie X
OncoTargets and therapy 2020;13:473-486
OncoTargets and therapy 2020;13:473-486
Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy.
Zhu Z, Li H, Chen W, Cui Y, Huang A, Qi X
Frontiers in pharmacology 2020;11:94
Frontiers in pharmacology 2020;11:94
Dexmedetomidine Mediates Neuroglobin Up-Regulation and Alleviates the Hypoxia/Reoxygenation Injury by Inhibiting Neuronal Apoptosis in Developing Rats.
Gao Y, Zhang Y, Dong Y, Wu X, Liu H
Frontiers in pharmacology 2020;11:555532
Frontiers in pharmacology 2020;11:555532
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
Su W, Zhao J, Fan TJ
Frontiers in pharmacology 2020;11:202
Frontiers in pharmacology 2020;11:202
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Yan Z, Zhan J, Qi W, Lin J, Huang Y, Xue X, Pan X
Frontiers in pharmacology 2020;11:1195
Frontiers in pharmacology 2020;11:1195
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis.
Huang J, Bao D, Lei CT, Tang H, Zhang CY, Su H, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):11983-11996
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):11983-11996
Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF-α-mediated osteoclast autophagy.
Liu W, Zhou J, Niu F, Pu F, Wang Z, Huang M, Zhao X, Yang L, Tao P, Xia P, Feng J
Experimental and therapeutic medicine 2020 Sep;20(3):1889-1898
Experimental and therapeutic medicine 2020 Sep;20(3):1889-1898
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Kong H, Wang H, Zhuo Z, Li Z, Tian P, Wu J, Liu J, Chen Z, Zhang J, Luo Q
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Dai GH, Chen X, Ren ZM, Dai CJ, Tong YL, Chai KQ
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.
Liu J, Deng X, Sun X, Dong J, Huang J
Life sciences 2020 Sep 15;257:118040
Life sciences 2020 Sep 15;257:118040
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells.
Wang L, Xu X, Liu T, Wang J, Shen J, Guo M, Wu Y, Zhai X, Zuo D
The Journal of pharmacy and pharmacology 2020 Oct;72(10):1370-1382
The Journal of pharmacy and pharmacology 2020 Oct;72(10):1370-1382
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334
Metabolism: clinical and experimental 2020 Oct;111:154334
T-type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation.
Chen M, Li S, Hao M, Chen J, Zhao Z, Hong S, Min J, Tang J, Hu M, Hong L
FEBS open bio 2020 Oct;10(10):2122-2136
FEBS open bio 2020 Oct;10(10):2122-2136
Transcriptomic and Proteomic Analysis Reveals Mechanisms of Patulin-Induced Cell Toxicity in Human Embryonic Kidney Cells.
Han N, Luo R, Liu J, Guo T, Feng J, Peng X
Toxins 2020 Oct 29;12(11)
Toxins 2020 Oct 29;12(11)
The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat.
Fu G, Dai J, Li Z, Chen F, Liu L, Yi L, Teng Z, Quan C, Zhang L, Zhou T, Donkersley P, Song S, Shi Y
Toxicology and applied pharmacology 2020 Oct 1;404:115151
Toxicology and applied pharmacology 2020 Oct 1;404:115151
Anthocyanins from Aronia melanocarpa Induce Apoptosis in Caco-2 Cells through Wnt/β-Catenin Signaling Pathway.
Wei J, Yu W, Hao R, Fan J, Gao J
Chemistry & biodiversity 2020 Nov;17(11):e2000654
Chemistry & biodiversity 2020 Nov;17(11):e2000654
Drp1-mediated mitochondrial fission induced autophagy attenuates cell apoptosis caused by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Zhong Y, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111740
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111740
Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Ji Y, Yao J, He Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Down-regulation of miR-383-5p suppresses apoptosis in oxidative stress rat hepatocytes by targeting Bcl2.
Xu B, Zang SC, Lang LM, Lian S, Lu J, Li SZ, Yang HM, Zhen L
Journal of animal physiology and animal nutrition 2020 Nov;104(6):1948-1959
Journal of animal physiology and animal nutrition 2020 Nov;104(6):1948-1959
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells.
Wang J, Liu X, Zheng H, Liu Q, Zhang H, Wang X, Shen T, Wang S, Ren D
Chemico-biological interactions 2020 Nov 1;331:109279
Chemico-biological interactions 2020 Nov 1;331:109279
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, Fan J, Wei S, Xu C, Huang L, Zhao H, Li X, Ye X
Biochemical pharmacology 2020 May;175:113933
Biochemical pharmacology 2020 May;175:113933
Antihypertensive and renal protective effect of Shunaoxin pill combined with captopril on spontaneous hypertension rats.
Man S, Yang L, Xiang H, Lu G, Wang Y, Liu C, Gao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109977
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109977
Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction.
Li S, Lin Q, Shao X, Zhu X, Wu J, Wu B, Zhang M, Zhou W, Zhou Y, Jin H, Zhang Z, Qi C, Shen J, Mou S, Gu L, Ni Z
Free radical biology & medicine 2020 May 20;152:632-649
Free radical biology & medicine 2020 May 20;152:632-649
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Xiao T, Sun J, Xing Z, Xie F, Yang L, Ding W
Cell biology international 2020 Mar;44(3):821-829
Cell biology international 2020 Mar;44(3):821-829
Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract.
Chen L, Wu X, Zeb F, Huang Y, An J, Jiang P, Chen A, Xu C, Feng Q
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113735
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113735
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Wang B, Xu H, Hu X, Ma W, Zhang J, Li Y, Yu M, Zhang Y, Li X, Ye X
Life sciences 2020 Mar 15;245:117387
Life sciences 2020 Mar 15;245:117387
Arginine promotes porcine type I muscle fibres formation through improvement of mitochondrial biogenesis.
Chen X, Luo X, Chen D, Yu B, He J, Huang Z
The British journal of nutrition 2020 Mar 14;123(5):499-507
The British journal of nutrition 2020 Mar 14;123(5):499-507
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18
Toxicology letters 2020 Mar 1;320:9-18
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Yu M, Zeng M, Pan Z, Wu F, Guo L, He G
European journal of medicinal chemistry 2020 Mar 1;189:112076
European journal of medicinal chemistry 2020 Mar 1;189:112076
Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and -resistant chronic myeloid leukaemia cells.
Jiang L, Wen C, He Q, Sun Y, Wang J, Lan X, Rohondia S, Dou QP, Shi X, Liu J
European journal of pharmacology 2020 Jun 5;876:173064
European journal of pharmacology 2020 Jun 5;876:173064
lncRNA MIRF Promotes Cardiac Apoptosis through the miR-26a-Bak1 Axis.
Su X, Lv L, Li Y, Fang R, Yang R, Li C, Li T, Zhu D, Li X, Zhou Y, Shan H, Liang H
Molecular therapy. Nucleic acids 2020 Jun 5;20:841-850
Molecular therapy. Nucleic acids 2020 Jun 5;20:841-850
Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.
Zhang X, Zhao D, Wu W, Ali Shah SZ, Lai M, Yang D, Li J, Guan Z, Li W, Gao H, Zhao H, Zhou X, Yang L
Aging 2020 Jun 10;12(11):11139-11151
Aging 2020 Jun 10;12(11):11139-11151
TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation.
Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X
The FEBS journal 2020 Jul;287(14):3088-3104
The FEBS journal 2020 Jul;287(14):3088-3104
Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
Bai R, Sun D, Chen M, Shi X, Luo L, Yao Z, Liu Y, Ge X, Gao X, Hu GF, Zhou W, Sheng J, Xu Z
The EMBO journal 2020 Jul 1;39(13):e103325
The EMBO journal 2020 Jul 1;39(13):e103325
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, Wu W, He G
European journal of medicinal chemistry 2020 Jul 1;197:112314
European journal of medicinal chemistry 2020 Jul 1;197:112314
Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
Peng F, Zhang N, Wang C, Wang X, Huang W, Peng C, He G, Han B
Cell proliferation 2020 Jan;53(1):e12701
Cell proliferation 2020 Jan;53(1):e12701
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Liu Y, Fan D
Nutrients 2020 Jan 18;12(1)
Nutrients 2020 Jan 18;12(1)
Novel diosgenin derivatives containing 1,3,4-oxadiazole/thiadiazole moieties as potential antitumor agents: Design, synthesis and cytotoxic evaluation.
Zhang J, Wang X, Yang J, Guo L, Wang X, Song B, Dong W, Wang W
European journal of medicinal chemistry 2020 Jan 15;186:111897
European journal of medicinal chemistry 2020 Jan 15;186:111897
Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA(2) phosphorylation in experimental ischemic stroke.
Cao C, Zhou J, Wu X, Qian Y, Hong Y, Mu J, Jin L, Zhu C, Li S
Cellular signalling 2020 Feb;66:109467
Cellular signalling 2020 Feb;66:109467
Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-/- mice via p66shc/cytochrome C cascade.
Zhang Y, Wang C, Lu J, Jin Y, Xu C, Meng Q, Liu Q, Dong D, Ma X, Liu K, Sun H
Aging 2020 Feb 5;12(3):2049-2069
Aging 2020 Feb 5;12(3):2049-2069
Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo.
Fan J, Ren D, Wang J, Liu X, Zhang H, Wu M, Yang G
Cell death & disease 2020 Feb 18;11(2):126
Cell death & disease 2020 Feb 18;11(2):126
S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis.
Wang Q, Zheng J, Zou JX, Xu J, Han F, Xiang S, Liu P, Chen HW, Wang J
Chemico-biological interactions 2020 Feb 1;317:108965
Chemico-biological interactions 2020 Feb 1;317:108965
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Yang X, Li Y, Chen L, Xu M, Wu J, Zhang P, Nel D, Sun B
Pharmaceutical biology 2020 Dec;58(1):686-694
Pharmaceutical biology 2020 Dec;58(1):686-694
Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.
Xue Y, Li M, Xue Y, Jin W, Han X, Zhang J, Chu X, Li Z, Chu L
Molecular medicine reports 2020 Dec;22(6):4663-4674
Molecular medicine reports 2020 Dec;22(6):4663-4674
Tongmai formula improves cardiac function via regulating mitochondrial quality control in the myocardium with ischemia/reperfusion injury.
Zhao Y, Guo R, Li L, Li S, Fan G, Zhao X, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Dec;132:110897
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Dec;132:110897
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
Latcripin-7A, derivative of Lentinula edodes C(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1) phase in breast cancer cells.
Din SRU, Zhong M, Nisar MA, Saleem MZ, Hussain A, Khinsar KH, Alam S, Ayub G, Kanwal S, Li X, Zhang W, Wang X, Ning A, Cao J, Huang M
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Ginsenoside M1 Induces Apoptosis and Inhibits the Migration of Human Oral Cancer Cells.
Lee YC, Wong WT, Li LH, Chu LJ, Menon MP, Ho CL, Chernikov OV, Lee SL, Hua KF
International journal of molecular sciences 2020 Dec 19;21(24)
International journal of molecular sciences 2020 Dec 19;21(24)
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Guan S, Tao S, Huang Y, Jin Y, Hu Y, Lu J
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Long non-coding RNA CRNDE promotes malignant progression of hepatocellular carcinoma through the miR-33a-5p/CDK6 axis.
Lin C, Xiang Y, Sheng J, Liu S, Cui M, Zhang X
Journal of physiology and biochemistry 2020 Aug;76(3):469-481
Journal of physiology and biochemistry 2020 Aug;76(3):469-481
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Yang T, Fan TJ, Xu B
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, Huang X, Jueraitetibaike K, Liang K, Wang S, Cao S, Zhao AZ, Yao B
Cell death & disease 2020 Aug 14;11(8):626
Cell death & disease 2020 Aug 14;11(8):626
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
Chen KL, Wang HL, Jiang LZ, Qian Y, Yang CX, Chang WW, Zhong JF, Xing GD
In vitro cellular & developmental biology. Animal 2020 Apr;56(4):322-331
In vitro cellular & developmental biology. Animal 2020 Apr;56(4):322-331
Downregulation of MiD49 contributes to tumor growth and metastasis of human pancreatic cancer.
Bai L, Liang J, Li L, Li E
Oncology reports 2020 Apr;43(4):1208-1220
Oncology reports 2020 Apr;43(4):1208-1220
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
Angelica sinensis extract protects against ischemia-reperfusion injury in the hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats.
Cheng CY, Kao ST, Lee YC
Journal of ethnopharmacology 2020 Apr 24;252:112612
Journal of ethnopharmacology 2020 Apr 24;252:112612
Sepiapterin reductase promotes hepatocellular carcinoma progression via FoxO3a/Bim signaling in a nonenzymatic manner.
Wu Y, Du H, Zhan M, Wang H, Chen P, Du D, Liu X, Huang X, Ma P, Peng D, Sun L, Yuan S, Ding J, Lu L, Jiang J
Cell death & disease 2020 Apr 20;11(4):248
Cell death & disease 2020 Apr 20;11(4):248
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Zhao Y, Wang Z, Feng D, Zhao H, Lin M, Hu Y, Zhang N, Lv L, Gao Z, Zhai X, Tian X, Yao J
Theranostics 2019;9(5):1510-1522
Theranostics 2019;9(5):1510-1522
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.
Li Z, Zhu T, Xu Y, Wu C, Chen J, Ren Y, Kong L, Sun S, Guo W, Wang Y, Jing C, Dong J, Zhou J, Zhang L, Shen Q, Zhou X
American journal of cancer research 2019;9(4):699-713
American journal of cancer research 2019;9(4):699-713
Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70/Bcl-2- and HSP70/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats.
Cheng CY, Kao ST, Lee YC
The American journal of Chinese medicine 2019;47(1):39-61
The American journal of Chinese medicine 2019;47(1):39-61
DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway.
Wang Z, Li C, Li Y, Guo X, Yan Z, Gao F, Li C
Oxidative medicine and cellular longevity 2019;2019:5414670
Oxidative medicine and cellular longevity 2019;2019:5414670
Tandem Molecular Self-Assembly Selectively Inhibits Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress.
Zheng D, Chen Y, Ai S, Zhang R, Gao Z, Liang C, Cao L, Chen Y, Hong Z, Shi Y, Wang L, Li X, Yang Z
Research (Washington, D.C.) 2019;2019:4803624
Research (Washington, D.C.) 2019;2019:4803624
LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.
Ye Z, Duan J, Wang L, Ji Y, Qiao B
Cancer cell international 2019;19:311
Cancer cell international 2019;19:311
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Khan MW, Zhao P, Khan A, Raza F, Raza SM, Sarfraz M, Chen Y, Li M, Yang T, Ma X, Xiang G
International journal of nanomedicine 2019;14:3753-3771
International journal of nanomedicine 2019;14:3753-3771
Homer1a Attenuates Endoplasmic Reticulum Stress-Induced Mitochondrial Stress After Ischemic Reperfusion Injury by Inhibiting the PERK Pathway.
Wei J, Wu X, Luo P, Yue K, Yu Y, Pu J, Zhang L, Dai S, Han D, Fei Z
Frontiers in cellular neuroscience 2019;13:101
Frontiers in cellular neuroscience 2019;13:101
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
Xu B, Sui YL, Fan TJ
International journal of ophthalmology 2019;12(10):1524-1530
International journal of ophthalmology 2019;12(10):1524-1530
Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.
Liao Y, Hussain T, Liu C, Cui Y, Wang J, Yao J, Chen H, Song Y, Sabir N, Hussain M, Zhao D, Zhou X
Frontiers in immunology 2019;10:268
Frontiers in immunology 2019;10:268
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, Zhang Z, Shen J, Zhou Y, Zhou W, Gu L, Lu R, Ni Z
Redox biology 2019 Sep;26:101254
Redox biology 2019 Sep;26:101254
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Maio N, Kim KS, Holmes-Hampton G, Singh A, Rouault TA
Haematologica 2019 Sep;104(9):1756-1767
Haematologica 2019 Sep;104(9):1756-1767
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway.
Wang Y, Zuo R, Wang Z, Luo L, Wu J, Zhang C, Liu M, Shi C, Zhou Y
Aging 2019 Sep 23;11(18):7961-7977
Aging 2019 Sep 23;11(18):7961-7977
Mechanisms of IFNalpha-1a-Induced Apoptosis in a Laryngeal Cancer Cell Line.
Xin XL, Zhang R, Yuan XM, Liu L
Medical science monitor : international medical journal of experimental and clinical research 2019 Sep 22;25:7100-7114
Medical science monitor : international medical journal of experimental and clinical research 2019 Sep 22;25:7100-7114
Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure.
Zhao H, Wang Y, Fei D, Guo M, Yang X, Mu M, Yu H, Xing M
Ecotoxicology and environmental safety 2019 Sep 15;179:167-174
Ecotoxicology and environmental safety 2019 Sep 15;179:167-174
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling.
Gao Y, Yin H, Zhang Y, Dong Y, Yang F, Wu X, Liu H
Life sciences 2019 Sep 1;232:116611
Life sciences 2019 Sep 1;232:116611
Comparison of hypoxic effects induced by chemical and physical hypoxia on cardiomyocytes.
Zhao RZ, Jiang S, Ru NY, Jiao B, Yu ZB
Canadian journal of physiology and pharmacology 2019 Oct;97(10):980-988
Canadian journal of physiology and pharmacology 2019 Oct;97(10):980-988
Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells.
Cao X, Wen P, Fu Y, Gao Y, Qi X, Chen B, Tao Y, Wu L, Xu A, Lu H, Zhao G
Cellular signalling 2019 Oct;62:109337
Cellular signalling 2019 Oct;62:109337
Fibrin matrix containing high-dose calcitriol promotes the apoptosis of gastric cancer cells by sustainably releasing calcitrol and D-dimer.
Hu P, Fang D, Shen L, Zhou H, Shao R, Chen M, Yao C, Shi Y, Chen Q
Journal of biomaterials applications 2019 Oct;34(4):509-522
Journal of biomaterials applications 2019 Oct;34(4):509-522
Cocktail Strategy Based on NK Cell-Derived Exosomes and Their Biomimetic Nanoparticles for Dual Tumor Therapy.
Wang G, Hu W, Chen H, Shou X, Ye T, Xu Y
Cancers 2019 Oct 14;11(10)
Cancers 2019 Oct 14;11(10)
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Yang HM, Li SZ
Brain sciences 2019 Oct 12;9(10)
Brain sciences 2019 Oct 12;9(10)
Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.
Hua S, Liu J, Zhang Y, Li J, Zhang X, Dong L, Zhao Y, Fu X
Food science & nutrition 2019 Nov;7(11):3443-3451
Food science & nutrition 2019 Nov;7(11):3443-3451
Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy.
Wang MR, Zhang XJ, Liu HC, Ma WD, Zhang ML, Zhang Y, Li X, Dou MM, Jing YL, Chu YJ, Zhu L
Brain research bulletin 2019 Nov;153:30-38
Brain research bulletin 2019 Nov;153:30-38
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Xu WN, Zheng HL, Yang RZ, Liu T, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection.
Lin P, Cheng Y, Song S, Qiu J, Yi L, Cao Z, Li J, Cheng S, Wang J
Journal of virology 2019 Nov 15;93(22)
Journal of virology 2019 Nov 15;93(22)
Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.
Mo D, Tian W, Zhang HN, Feng YD, Sun Y, Quan W, Hao XW, Wang XY, Liu XX, Li C, Cao W, Liu WJ, Li XQ
European journal of pharmacology 2019 Nov 15;863:172701
European journal of pharmacology 2019 Nov 15;863:172701
Activation of Nrf2 signaling by Icariin protects against 6-OHDA-induced neurotoxicity.
Zhu L, Li D, Chen C, Wang G, Shi J, Zhang F
Biotechnology and applied biochemistry 2019 May;66(3):465-471
Biotechnology and applied biochemistry 2019 May;66(3):465-471
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
Sheng J, Shen L, Sun L, Zhang X, Cui R, Wang L
Cell proliferation 2019 May;52(3):e12609
Cell proliferation 2019 May;52(3):e12609
1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.
Fan J, Wu M, Wang J, Ren D, Zhao J, Yang G
Journal of cellular physiology 2019 May;234(5):6336-6349
Journal of cellular physiology 2019 May;234(5):6336-6349
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Shi H, Yao R, Lian S, Liu P, Liu Y, Yang YY, Yang H, Li S
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
Sabir N, Hussain T, Liao Y, Wang J, Song Y, Shahid M, Cheng G, Mangi MH, Yao J, Yang L, Zhao D, Zhou X
Cells 2019 May 5;8(5)
Cells 2019 May 5;8(5)
Mitochondrial separation protein inhibitor inhibits cell apoptosis in rat lungs during intermittent hypoxia.
Zhao D, Yin CY, Ye XW, Wan ZF, Zhao DG, Zhang XY
Experimental and therapeutic medicine 2019 Mar;17(3):2349-2358
Experimental and therapeutic medicine 2019 Mar;17(3):2349-2358
Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury.
Liu Z, Li T, Zhu F, Deng S, Li X, He Y
Cell death & disease 2019 Mar 7;10(3):227
Cell death & disease 2019 Mar 7;10(3):227
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
H(2)S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling.
Zhang Y, Gao J, Sun W, Wen X, Xi Y, Wang Y, Wei C, Xu C, Li H
Aging 2019 Mar 26;11(6):1745-1758
Aging 2019 Mar 26;11(6):1745-1758
Effects of okadaic acid and hematein on human lung adenocarcinoma A549 cells and responses of mitochondria and endoplasmic reticulum apoptosis pathways.
Wang R, Wang J, Ding N, He S, Zhao Y, Gao P
Translational cancer research 2019 Jun;8(3):968-975
Translational cancer research 2019 Jun;8(3):968-975
Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release.
Zhang Z, Lei Y, Yan C, Mei X, Jiang T, Ma Z, Wang Q
Inflammation 2019 Jun;42(3):1082-1092
Inflammation 2019 Jun;42(3):1082-1092
Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia.
Yang L, Dong Y, Wu C, Li Y, Guo Y, Yang B, Zong X, Hamblin MR, Liu TC, Zhang Q
Journal of biophotonics 2019 Jun;12(6):e201800359
Journal of biophotonics 2019 Jun;12(6):e201800359
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
Dong S, Ji J, Hu L, Wang H
Life sciences 2019 Jun 15;227:20-29
Life sciences 2019 Jun 15;227:20-29
The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells.
Cui C, Li Z, Wu D
Biological research 2019 Jun 13;52(1):32
Biological research 2019 Jun 13;52(1):32
2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2.
Zhou P, Chen X, Li M, Tan J, Zhang Y, Yuan W, Zhou J, Wang G
Biochemical and biophysical research communications 2019 Jun 11;513(4):1063-1069
Biochemical and biophysical research communications 2019 Jun 11;513(4):1063-1069
Crocin protects against dexamethasone‑induced osteoblast apoptosis by inhibiting the ROS/Ca2+‑mediated mitochondrial pathway.
Nie Z, Deng S, Zhang L, Chen S, Lu Q, Peng H
Molecular medicine reports 2019 Jul;20(1):401-408
Molecular medicine reports 2019 Jul;20(1):401-408
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Zhang L, Li F, Su X, Li Y, Wang Y, Fang R, Guo Y, Jin T, Shan H, Zhao X, Yang R, Shan H, Liang H
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway.
Yin F, Yan J, Zhao Y, Guo KJ, Zhang ZL, Li AP, Meng CY, Guo L
Ecotoxicology and environmental safety 2019 Jul 30;176:234-241
Ecotoxicology and environmental safety 2019 Jul 30;176:234-241
TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway.
Ni B, Shen H, Wang W, Lu H, Jiang L
Journal of orthopaedic surgery and research 2019 Jul 29;14(1):241
Journal of orthopaedic surgery and research 2019 Jul 29;14(1):241
Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.
Zheng L, Han X, Hu Y, Zhao X, Yin L, Xu L, Qi Y, Xu Y, Han X, Liu K, Peng J
Pharmacological research 2019 Jan;139:431-439
Pharmacological research 2019 Jan;139:431-439
The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells.
Li Z, Li Q, Lv W, Jiang L, Geng C, Yao X, Shi X, Liu Y, Cao J
Free radical biology & medicine 2019 Jan;130:576-591
Free radical biology & medicine 2019 Jan;130:576-591
Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.
Wang Y, Liu Y, Li Y, Liu B, Wu P, Xu S, Shi H
Acta histochemica 2019 Jan;121(1):56-63
Acta histochemica 2019 Jan;121(1):56-63
A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis.
Liu HM, Wu Q, Cao JQ, Wang X, Song Y, Mei WJ, Wang XC
European journal of pharmacology 2019 Jan 15;843:285-291
European journal of pharmacology 2019 Jan 15;843:285-291
Leucine regulates slow-twitch muscle fibers expression and mitochondrial function by Sirt1/AMPK signaling in porcine skeletal muscle satellite cells.
Chen X, Xiang L, Jia G, Liu G, Zhao H, Huang Z
Animal science journal = Nihon chikusan Gakkaiho 2019 Feb;90(2):255-263
Animal science journal = Nihon chikusan Gakkaiho 2019 Feb;90(2):255-263
Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats.
Diao J, Wei J, Yan R, Fan G, Lin L, Chen M
Journal of physiology and biochemistry 2019 Feb;75(1):39-51
Journal of physiology and biochemistry 2019 Feb;75(1):39-51
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H
Inflammation 2019 Feb;42(1):64-80
Inflammation 2019 Feb;42(1):64-80
Casticin inhibits esophageal cancer cell proliferation and promotes apoptosis by regulating mitochondrial apoptotic and JNK signaling pathways.
Qiao Z, Cheng Y, Liu S, Ma Z, Li S, Zhang W
Naunyn-Schmiedeberg's archives of pharmacology 2019 Feb;392(2):177-187
Naunyn-Schmiedeberg's archives of pharmacology 2019 Feb;392(2):177-187
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ma H, Yu Y, Wang M, Li Z, Xu H, Tian C, Zhang J, Ye X, Li X
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Ferulic acid ameliorates cerebral infarction by activating Akt/mTOR/4E‑BP1/Bcl‑2 anti‑apoptotic signaling in the penumbral cortex following permanent cerebral ischemia in rats.
Cheng CY, Kao ST, Lee YC
Molecular medicine reports 2019 Feb;19(2):792-804
Molecular medicine reports 2019 Feb;19(2):792-804
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545
Aging 2019 Dec 16;11(24):12532-12545
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Liu JZ, Hu YL, Feng Y, Guo YB, Liu YF, Yang JL, Mao QS, Xue WJ
Experimental cell research 2019 Dec 15;385(2):111691
Experimental cell research 2019 Dec 15;385(2):111691
Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy.
Wang Y, Mao X, Chen H, Feng J, Yan M, Wang Y, Yu Y
International immunopharmacology 2019 Aug;73:471-481
International immunopharmacology 2019 Aug;73:471-481
A novel iron(II) phenanthroline complex exhibits anticancer activity against TFR1-overexpressing esophageal squamous cell carcinoma cells through ROS accumulation and DNA damage.
Ye J, Ma J, Liu C, Huang J, Wang L, Zhong X
Biochemical pharmacology 2019 Aug;166:93-107
Biochemical pharmacology 2019 Aug;166:93-107
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
Shang Y, Wang Q, Wu B, Zhao Q, Li J, Huang X, Chen W, Gui R
ACS applied materials & interfaces 2019 Aug 7;11(31):28254-28266
ACS applied materials & interfaces 2019 Aug 7;11(31):28254-28266
Protective effects of ethyl gallate on H(2)O(2)-induced mitochondrial dysfunction in PC12 cells.
Chen L, Wu X, Shen T, Wang X, Wang S, Wang J, Ren D
Metabolic brain disease 2019 Apr;34(2):545-555
Metabolic brain disease 2019 Apr;34(2):545-555
Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.
Li XG, Du JH, Lu Y, Lin XJ
Neural regeneration research 2019 Apr;14(4):721-727
Neural regeneration research 2019 Apr;14(4):721-727
Glucocorticoid induces osteonecrosis of the femoral head in rats through GSK3β-mediated osteoblast apoptosis.
Nie Z, Chen S, Peng H
Biochemical and biophysical research communications 2019 Apr 9;511(3):693-699
Biochemical and biophysical research communications 2019 Apr 9;511(3):693-699
Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells.
Hong Y, Fan D
Toxicology 2019 Apr 15;418:22-31
Toxicology 2019 Apr 15;418:22-31
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Mao J, Yi M, Wang R, Huang Y, Chen M
Frontiers in pharmacology 2018;9:1469
Frontiers in pharmacology 2018;9:1469
Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study.
Hu XN, Wang JF, Huang YQ, Wang Z, Dong FY, Ma HF, Bao ZJ
PeerJ 2018;6:e5145
PeerJ 2018;6:e5145
Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer.
Sun X, Zhan L, Chen Y, Wang G, He L, Wang Q, Zhou F, Yang F, Wu J, Wu Y, Xing J, He X, Huang Q
Signal transduction and targeted therapy 2018;3:8
Signal transduction and targeted therapy 2018;3:8
The Role of TLR4 on PGC-1α-Mediated Oxidative Stress in Tubular Cell in Diabetic Kidney Disease.
Yuan S, Liu X, Zhu X, Qu Z, Gong Z, Li J, Xiao L, Yang Y, Liu H, Sun L, Liu F
Oxidative medicine and cellular longevity 2018;2018:6296802
Oxidative medicine and cellular longevity 2018;2018:6296802
p66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke.
Zhang M, Tang J, Shan H, Zhang Q, Yang X, Zhang J, Li Y
Oxidative medicine and cellular longevity 2018;2018:5837123
Oxidative medicine and cellular longevity 2018;2018:5837123
Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction.
Yin S, Zhang L, Ding L, Huang Z, Xu B, Li X, Wang P, Mao J
Journal of inflammation (London, England) 2018;15:27
Journal of inflammation (London, England) 2018;15:27
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.
Wang J, Li M, Cui X, Lv D, Jin L, Khan M, Ma T
OncoTargets and therapy 2018;11:7031-7040
OncoTargets and therapy 2018;11:7031-7040
Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy.
Wang L, Hu Y, Hao Y, Li L, Zheng C, Zhao H, Niu M, Yin Y, Zhang Z, Zhang Y
Journal of controlled release : official journal of the Controlled Release Society 2018 Sep 28;286:74-84
Journal of controlled release : official journal of the Controlled Release Society 2018 Sep 28;286:74-84
The effect of shear on the cytoskeleton remodeling and physiological performance of myocardium cells through Tmod1.
Zhao L, Li X, Niu P, Li L
RSC advances 2018 Sep 24;8(58):33347-33353
RSC advances 2018 Sep 24;8(58):33347-33353
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Xu H, Li Y, Han B, Li Z, Wang B, Jiang P, Zhang J, Ma W, Zhou D, Li X, Ye X
Journal of agricultural and food chemistry 2018 Sep 19;66(37):9704-9718
Journal of agricultural and food chemistry 2018 Sep 19;66(37):9704-9718
Cattle Encephalon Glycoside and Ignotin Reduce Early Brain Injury and Cognitive Dysfunction after Subarachnoid Hemorrhage in Rats.
Ma K, Li R, Zhao H, Qu J, Mu N, Liu X, Wang S, Yang C, Feng H, Tan L, Li F
Neuroscience 2018 Sep 15;388:181-190
Neuroscience 2018 Sep 15;388:181-190
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Yu G, Liao J, Wu J, Ding J, Zhang L
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
Acrolein-induced autophagy-dependent apoptosis via activation of the lysosomal-mitochondrial pathway in EAhy926 cells.
Luo S, Jiang L, Li Q, Sun X, Liu T, Pei F, Zhang T, Liu T, Dong L, Liu X, Jiang L
Toxicology in vitro : an international journal published in association with BIBRA 2018 Oct;52:146-153
Toxicology in vitro : an international journal published in association with BIBRA 2018 Oct;52:146-153
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.
Peng Y, Wang Y, Tang N, Sun D, Lan Y, Yu Z, Zhao X, Feng L, Zhang B, Jin L, Yu F, Ma X, Lv C
Journal of experimental & clinical cancer research : CR 2018 Oct 12;37(1):248
Journal of experimental & clinical cancer research : CR 2018 Oct 12;37(1):248
Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells.
Sun M, Wang S, Jiang L, Bai Y, Sun X, Li J, Wang B, Yao X, Liu X, Li Q, Geng C, Zhang C, Yang G
Journal of agricultural and food chemistry 2018 Nov 21;66(46):12376-12384
Journal of agricultural and food chemistry 2018 Nov 21;66(46):12376-12384
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Liu Y, Fan D
Food & function 2018 Nov 14;9(11):5513-5527
Food & function 2018 Nov 14;9(11):5513-5527
Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.
Lai X, Su W, Zhao H, Yang S, Zeng T, Wu W, Wang D
FEBS open bio 2018 May;8(5):743-750
FEBS open bio 2018 May;8(5):743-750
Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.
Cai J, Jiang Y, Zhang M, Zhao H, Li H, Li K, Zhang X, Qiao T
Journal of physiology and biochemistry 2018 May;74(2):335-343
Journal of physiology and biochemistry 2018 May;74(2):335-343
Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells.
Xu L, Xie Q, Qi L, Wang C, Xu N, Liu W, Yu Y, Li S, Xu Y
Oncology reports 2018 Mar;39(3):985-992
Oncology reports 2018 Mar;39(3):985-992
Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.
Zhang Y, Li H, Yang X, Jin G, Zhang Y
International journal of biological macromolecules 2018 Jun;112:788-795
International journal of biological macromolecules 2018 Jun;112:788-795
SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells.
Wu Y, Gao WN, Xue YN, Zhang LC, Zhang JJ, Lu SY, Yan XY, Yu HM, Su J, Sun LK
Experimental cell research 2018 Jun 15;367(2):137-149
Experimental cell research 2018 Jun 15;367(2):137-149
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release.
Xie Q, Xu Y, Gao W, Zhang Y, Su J, Liu Y, Guo Y, Dou M, Hu K, Sun L
International journal of molecular medicine 2018 Feb;41(2):809-817
International journal of molecular medicine 2018 Feb;41(2):809-817
Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis.
Zhao W, Che C, Liu K, Zhang J, Jiang N, Yuan K, Zhao G
Cornea 2018 Dec;37(12):1579-1585
Cornea 2018 Dec;37(12):1579-1585
Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration.
Tang W, Ma J, Gu R, Lei B, Ding X, Xu G
Investigative ophthalmology & visual science 2018 Dec 3;59(15):6014-6025
Investigative ophthalmology & visual science 2018 Dec 3;59(15):6014-6025
Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity.
Wang M, Chen Y, Guo Z, Yang C, Qi J, Fu Y, Chen Z, Chen P, Wang Y
Toxicon : official journal of the International Society on Toxinology 2018 Dec 15;156:34-40
Toxicon : official journal of the International Society on Toxinology 2018 Dec 15;156:34-40
Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.
Bai Z, Gao M, Xu X, Zhang H, Xu J, Guan Q, Wang Q, Du J, Li Z, Zuo D, Zhang W, Wu Y
Cell proliferation 2018 Aug;51(4):e12450
Cell proliferation 2018 Aug;51(4):e12450
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Wu F, Li S, Zhang N, Huang W, Li X, Wang M, Bai D, Han B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:307-314
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:307-314
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Cheng L, Chen L, Wei X, Wang Y, Ren Z, Zeng S, Zhang X, Wen H, Gao C, Liu H
Journal of neuroinflammation 2018 Aug 29;15(1):243
Journal of neuroinflammation 2018 Aug 29;15(1):243
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.
Wang X, Su GY, Zhao C, Qu FZ, Wang P, Zhao YQ
Journal of ginseng research 2018 Apr;42(2):133-143
Journal of ginseng research 2018 Apr;42(2):133-143
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, Huang Q, Guo X, Zhang J, Ji L, Li J, Zhang H, Yang H, Xing J
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Dai C, Ciccotosto GD, Cappai R, Wang Y, Tang S, Hoyer D, Schneider EK, Velkov T, Xiao X
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Mehmood T, Maryam A, Tian X, Khan M, Ma T
Journal of Cancer 2017;8(18):3707-3717
Journal of Cancer 2017;8(18):3707-3717
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
Wang A, Ning Z, Lu C, Gao W, Liang J, Yan Q, Tan G, Liu J
Frontiers in pharmacology 2017;8:274
Frontiers in pharmacology 2017;8:274
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Wei WJ, Sun ZK, Shen CT, Song HJ, Zhang XY, Qiu ZL, Luo QY
Theranostics 2017;7(4):987-1001
Theranostics 2017;7(4):987-1001
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Sun W, Yang J, Zhang Y, Xi Y, Wen X, Yuan D, Wang Y, Wei C, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2017;7:67
Cell & bioscience 2017;7:67
Angelica sinensis Exerts Angiogenic and Anti-apoptotic Effects Against Cerebral Ischemia-Reperfusion Injury by Activating p38MAPK/HIF-1[Formula: see text]/VEGF-A Signaling in Rats.
Cheng CY, Ho TY, Hsiang CY, Tang NY, Hsieh CL, Kao ST, Lee YC
The American journal of Chinese medicine 2017;45(8):1683-1708
The American journal of Chinese medicine 2017;45(8):1683-1708
Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway.
Yang F, Zhang L, Gao Z, Sun X, Yu M, Dong S, Wu J, Zhao Y, Xu C, Zhang W, Lu F
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1168-1187
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1168-1187
Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice.
Ma S, Zhong D, Ma P, Li G, Hua W, Sun Y, Liu N, Zhang L, Zhang W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1838-1850
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1838-1850
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, Deng G, Li M, Liu X, Wang Y
Oxidative medicine and cellular longevity 2017;2017:6175841
Oxidative medicine and cellular longevity 2017;2017:6175841
Intranasal Delivery of a Caspase-1 Inhibitor in the Treatment of Global Cerebral Ischemia.
Zhao N, Zhuo X, Lu Y, Dong Y, Ahmed ME, Tucker D, Scott EL, Zhang Q
Molecular neurobiology 2017 Sep;54(7):4936-4952
Molecular neurobiology 2017 Sep;54(7):4936-4952
Tilianin Post-Conditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondrial Protection and Inhibition of Apoptosis.
Wang Y, Yuan Y, Wang X, Wang Y, Cheng J, Tian L, Guo X, Qin D, Cao W
Medical science monitor : international medical journal of experimental and clinical research 2017 Sep 18;23:4490-4499
Medical science monitor : international medical journal of experimental and clinical research 2017 Sep 18;23:4490-4499
Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis.
Liu Z, Wang Y, Wang Y, Dong W, Xia X, Song E, Song Y
Chemical research in toxicology 2017 Oct 16;30(10):1804-1814
Chemical research in toxicology 2017 Oct 16;30(10):1804-1814
Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Yuan K, Zhao G, Che C, Li C, Lin J, Zhu G, He K
International immunopharmacology 2017 Nov;52:168-175
International immunopharmacology 2017 Nov;52:168-175
Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression.
Chen L, Cong D, Li Y, Wang D, Li Q, Hu S
Ultrasonics sonochemistry 2017 Nov;39:654-661
Ultrasonics sonochemistry 2017 Nov;39:654-661
Inhibited effects of CAPE-pNO(2) on cervical carcinoma in vivo and in vitro and its detected metabolites.
Yao X, Tang H, Ren Q, Zhao X, Zuo H, Li Z
Oncotarget 2017 Nov 7;8(55):94197-94209
Oncotarget 2017 Nov 7;8(55):94197-94209
Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.
Khan SH, Zhao D, Shah SZ, Hassan MF, Zhu T, Song Z, Zhou X, Yang L
Cellular and molecular neurobiology 2017 May;37(4):717-728
Cellular and molecular neurobiology 2017 May;37(4):717-728
Mitochondrial Dysfunction and Ca(2+) Overload in Injured Sertoli Cells Exposed to Bisphenol A.
Wang C, Qi S, Liu C, Yang A, Fu W, Quan C, Duan P, Yu T, Yang K
Environmental toxicology 2017 Mar;32(3):823-831
Environmental toxicology 2017 Mar;32(3):823-831
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Yang F, Yu X, Li T, Wu J, Zhao Y, Liu J, Sun A, Dong S, Wu J, Zhong X, Xu C, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca(2+)-Dependent Antioxidant Response.
Ji L, Liu F, Jing Z, Huang Q, Zhao Y, Cao H, Li J, Yin C, Xing J, Li F
Diabetes 2017 Jun;66(6):1586-1600
Diabetes 2017 Jun;66(6):1586-1600
Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway.
Liu J, Zhang Y, Chen L, Yu F, Li X, Dan Tao, Zhao J, Zhou S
Acta biochimica et biophysica Sinica 2017 Jun 1;49(6):479-486
Acta biochimica et biophysica Sinica 2017 Jun 1;49(6):479-486
Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis.
Wang YJ, Yan J, Zou XL, Guo KJ, Zhao Y, Meng CY, Yin F, Guo L
Chemico-biological interactions 2017 Jun 1;271:39-47
Chemico-biological interactions 2017 Jun 1;271:39-47
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
Su WC, Lin YF, Yu XP, Wang YX, Lin XD, Su QZ, Shen DY, Chen QX
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition and mitochondrial dysfunction.
Mehmood T, Maryam A, Zhang H, Li Y, Khan M, Ma T
BioFactors (Oxford, England) 2017 Jan 2;43(1):63-72
BioFactors (Oxford, England) 2017 Jan 2;43(1):63-72
Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models.
Sun H, He X, Liu C, Li L, Zhou R, Jin T, Yue S, Feng D, Gong J, Sun J, Ji J, Xiang L
ACS chemical neuroscience 2017 Jan 18;8(1):155-164
ACS chemical neuroscience 2017 Jan 18;8(1):155-164
Triggering of apoptosis in osteosarcoma cells by graphene/single-walled carbon nanotube hybrids via the ROS-mediated mitochondrial pathway.
Yan X, Yang W, Shao Z, Yang S, Liu X
Journal of biomedical materials research. Part A 2017 Feb;105(2):443-453
Journal of biomedical materials research. Part A 2017 Feb;105(2):443-453
ABT737 induces mitochondrial pathway apoptosis and mitophagy by regulating DRP1-dependent mitochondrial fission in human ovarian cancer cells.
Yu Y, Xu L, Qi L, Wang C, Xu N, Liu S, Li S, Tian H, Liu W, Xu Y, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:22-29
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:22-29
Ablation of β,β-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.
Guo X, Wu L, Lyu Y, Chowanadisai W, Clarke SL, Lucas EA, Smith BJ, He H, Wang W, Medeiros DM, Lin D
The Journal of nutritional biochemistry 2017 Aug;46:74-82
The Journal of nutritional biochemistry 2017 Aug;46:74-82
Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells.
Wu X, Jiang L, Sun X, Yao X, Bai Y, Liu X, Liu N, Zhai X, Wang S, Yang G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Aug;106(Pt A):273-282
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Aug;106(Pt A):273-282
CO-releasing molecules-2 attenuates ox-LDL-induced injury in HUVECs by ameliorating mitochondrial function and inhibiting Wnt/β-catenin pathway.
Sun HJ, Xu DY, Sun YX, Xue T, Zhang CX, Zhang ZX, Lin W, Li KX
Biochemical and biophysical research communications 2017 Aug 26;490(3):629-635
Biochemical and biophysical research communications 2017 Aug 26;490(3):629-635
Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis.
Xu W, Zhu Q, Zhang B, Liu S, Dai X, Gao C, Gao L, Cui Y
Aging 2017 Apr;9(4):1269-1279
Aging 2017 Apr;9(4):1269-1279
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Activation of Na(+)-K(+)-ATPase with DRm217 attenuates oxidative stress-induced myocardial cell injury via closing Na(+)-K(+)-ATPase/Src/Ros amplifier.
Yan X, Xun M, Dou X, Wu L, Zhang F, Zheng J
Apoptosis : an international journal on programmed cell death 2017 Apr;22(4):531-543
Apoptosis : an international journal on programmed cell death 2017 Apr;22(4):531-543
Inhibition of p66Shc-mediated mitochondrial apoptosis via targeting prolyl-isomerase Pin1 attenuates intestinal ischemia/reperfusion injury in rats.
Feng D, Yao J, Wang G, Li Z, Zu G, Li Y, Luo F, Ning S, Qasim W, Chen Z, Tian X
Clinical science (London, England : 1979) 2017 Apr 25;131(8):759-773
Clinical science (London, England : 1979) 2017 Apr 25;131(8):759-773
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes.
Li L, Li M, Li Y, Sun W, Wang Y, Bai S, Li H, Wu B, Yang G, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2016;6:26
Cell & bioscience 2016;6:26
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
Cui Y, Zhao D, Sreevatsan S, Liu C, Yang W, Song Z, Yang L, Barrow P, Zhou X
Frontiers in cellular and infection microbiology 2016;6:182
Frontiers in cellular and infection microbiology 2016;6:182
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
Zhang Z, Li C, Shang L, Zhang Y, Zou R, Zhan Y, Bi B
SpringerPlus 2016;5:235
SpringerPlus 2016;5:235
Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.
Duan F, Yu Y, Guan R, Xu Z, Liang H, Hong L
PloS one 2016;11(8):e0161886
PloS one 2016;11(8):e0161886
Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells.
Wu L, Bao K, Song R, Wang D, Zhang L, Wang W, Zhang W, Bin W
PloS one 2016;11(7):e0159503
PloS one 2016;11(7):e0159503
Ferulic Acid Administered at Various Time Points Protects against Cerebral Infarction by Activating p38 MAPK/p90RSK/CREB/Bcl-2 Anti-Apoptotic Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion Injury in Rats.
Cheng CY, Tang NY, Kao ST, Hsieh CL
PloS one 2016;11(5):e0155748
PloS one 2016;11(5):e0155748
Improvement and enhancement of antibladder carcinoma cell effects of heteronemin by the nanosized hyaluronan aggregation.
Huang HH, Kuo SM, Wu YJ, Su JH
International journal of nanomedicine 2016;11:1237-51
International journal of nanomedicine 2016;11:1237-51
Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition.
Ju JS, Jeon SI, Park JY, Lee JY, Lee SC, Cho KJ, Jeong JM
The journal of physiological sciences : JPS 2016 Sep;66(5):417-30
The journal of physiological sciences : JPS 2016 Sep;66(5):417-30
Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.
Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, Yao H
Autophagy 2016 Sep;12(9):1538-59
Autophagy 2016 Sep;12(9):1538-59
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Li Y, Jiang Z, Xue D, Deng G, Li M, Liu X, Wang Y
BMC microbiology 2016 Sep 23;16(1):222
BMC microbiology 2016 Sep 23;16(1):222
Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation.
Zheng X, Zhang Y, Zhang L, Xu W, Ma W, Sun R, Zeng H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:212-220
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:212-220
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Song G, Napoli E, Wong S, Hagerman R, Liu S, Tassone F, Giulivi C
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.
Selsby JT, Ballmann CG, Spaulding HR, Ross JW, Quindry JC
The Journal of physiology 2016 Oct 15;594(20):6037-6053
The Journal of physiology 2016 Oct 15;594(20):6037-6053
Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8/3.
Kong F, Wang H, Guo J, Peng M, Ji H, Yang H, Liu B, Wang J, Zhang X, Li S
In vitro cellular & developmental biology. Animal 2016 May;52(5):568-75
In vitro cellular & developmental biology. Animal 2016 May;52(5):568-75
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.
Sun Z, Lan X, Ahsan A, Xi Y, Liu S, Zhang Z, Chu P, Song Y, Piao F, Peng J, Lin Y, Han G, Tang Z
Apoptosis : an international journal on programmed cell death 2016 Mar;21(3):283-97
Apoptosis : an international journal on programmed cell death 2016 Mar;21(3):283-97
Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock.
Yu Y, Xu X, Liu L, Mao S, Feng T, Lu Y, Cheng Y, Wang H, Zhao W, Tang W
Journal of cellular and molecular medicine 2016 Mar;20(3):506-17
Journal of cellular and molecular medicine 2016 Mar;20(3):506-17
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Si L, Zheng L, Xu L, Yin L, Han X, Qi Y, Xu Y, Wang C, Peng J
European journal of pharmacology 2016 Mar 5;774:105-17
European journal of pharmacology 2016 Mar 5;774:105-17
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Li X, Song Y, Zhang P, Zhu H, Chen L, Xiao Y, Xing Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7599-613
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7599-613
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, Zhang J, Ji L, Ren T, An J, Liu B, Nie Y, Xing J
Autophagy 2016 Jun 2;12(6):999-1014
Autophagy 2016 Jun 2;12(6):999-1014
Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.
Peng X, Zhang YY, Wang J, Ji Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jan;37(1):865-76
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jan;37(1):865-76
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Lei X, Cui K, Liu Q, Zhang H, Li Z, Huang B, Shi D
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84
Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.
Zhang C, Jia X, Bao J, Chen S, Wang K, Zhang Y, Li P, Wan JB, Su H, Wang Y, Mei Z, He C
BMC complementary and alternative medicine 2016 Feb 9;16:58
BMC complementary and alternative medicine 2016 Feb 9;16:58
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
Li X, Lin Z, Zhang B, Guo L, Liu S, Li H, Zhang J, Ye Q
Scientific reports 2016 Feb 12;6:21010
Scientific reports 2016 Feb 12;6:21010
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849
Journal of medical genetics 2016 Dec;53(12):846-849
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Xie Q, Su J, Jiao B, Shen L, Ma L, Qu X, Yu C, Jiang X, Xu Y, Sun L
International journal of oncology 2016 Dec;49(6):2507-2519
International journal of oncology 2016 Dec;49(6):2507-2519
Pim-2 protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced apoptosis via downregulation of Bim expression.
Xu Y, Xing Y, Xu Y, Huang C, Bao H, Hong K, Cheng X
Environmental toxicology and pharmacology 2016 Dec;48:94-102
Environmental toxicology and pharmacology 2016 Dec;48:94-102
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, Sun B
Oncotarget 2016 Dec 6;7(49):81077-81089
Oncotarget 2016 Dec 6;7(49):81077-81089
Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells.
Wen C, Chen J, Zhang D, Wang H, Che J, Qin Q, He L, Cai Z, Lin M, Lou Q, Huang L, Chen D, Iwamoto A, Ren D, Wang L, Lan P, Wang J, Liu H, Yang X
Cancer letters 2016 Dec 28;383(2):295-308
Cancer letters 2016 Dec 28;383(2):295-308
Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.
Zhang G, Xu M, Zhang H, Song Y, Wang J, Zhang C
Toxicology and applied pharmacology 2016 Dec 15;313:1-9
Toxicology and applied pharmacology 2016 Dec 15;313:1-9
PUMA and survivin are involved in the apoptosis of HepG2 cells induced by microcystin-LR via mitochondria-mediated pathway.
Ma J, Feng Y, Liu Y, Li X
Chemosphere 2016 Aug;157:241-9
Chemosphere 2016 Aug;157:241-9
ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway.
Chen X, Wang L, Zhao Y, Yuan S, Wu Q, Zhu X, Niang B, Wang S, Zhang J
Oncotarget 2016 Aug 9;7(32):51955-51964
Oncotarget 2016 Aug 9;7(32):51955-51964
Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction.
Gao W, Liang JX, Liu S, Liu C, Liu XF, Wang XQ, Yan Q
International journal of clinical and experimental medicine 2015;8(3):3401-10
International journal of clinical and experimental medicine 2015;8(3):3401-10
Exogenous spermine ameliorates high glucose-induced cardiomyocytic apoptosis via decreasing reactive oxygen species accumulation through inhibiting p38/JNK and JAK2 pathways.
He Y, Yang J, Li H, Shao H, Wei C, Wang Y, Li M, Xu C
International journal of clinical and experimental pathology 2015;8(12):15537-49
International journal of clinical and experimental pathology 2015;8(12):15537-49
Inhibition of Hepatocyte Apoptosis: An Important Mechanism of Corn Peptides Attenuating Liver Injury Induced by Ethanol.
Ma Z, Hou T, Shi W, Liu W, He H
International journal of molecular sciences 2015 Sep 11;16(9):22062-80
International journal of molecular sciences 2015 Sep 11;16(9):22062-80
Cold-inducible RNA-binding protein inhibits neuron apoptosis through the suppression of mitochondrial apoptosis.
Zhang HT, Xue JH, Zhang ZW, Kong HB, Liu AJ, Li SC, Xu DG
Brain research 2015 Oct 5;1622:474-83
Brain research 2015 Oct 5;1622:474-83
An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells.
Shi J, Ren C, Liu H, Wang L, Zhu B, Huang W, Liu W, Liu J, Liu Y, Xia X, Xu R, Jiang X
Biochemical and biophysical research communications 2015 May 1;460(2):130-5
Biochemical and biophysical research communications 2015 May 1;460(2):130-5
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
Li X, Liu X, Xu Y, He Y, Liu J, Xie M
International journal of oncology 2015 Feb;46(2):677-84
International journal of oncology 2015 Feb;46(2):677-84
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.
Che X, He F, Deng Y, Xu S, Fan X, Gu P, Wang Z
PloS one 2014;9(4):e95420
PloS one 2014;9(4):e95420
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Carcinogenesis 2014 Mar;35(3):613-23
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Biochemical and biophysical research communications 2014 Jun 20;449(1):62-8
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Emodin regulates apoptotic pathway in human liver cancer cells.
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Cancer gene therapy 2013 Feb;20(2):77-81
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Experimental and therapeutic medicine 2013 Aug;6(2):574-578
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
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Gong K, Xie J, Yi H, Li W
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The Biochemical journal 2012 May 1;443(3):735-46
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 10993-1-AP(CYCS antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10993-1-AP(CYCS antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Cytochrome c antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Cytochrome c. This antibody recognizes human, mouse, rat antigen. The Cytochrome c antibody has been validated for the following applications: ELISA, IHC, WB analysis.
