CYCS

This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome. [provided by RefSeq, Jul 2010]

Description

Cytochrome c, somatic

Tissue specificity

Tissue enhanced (tongue)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (25118656 - 25125260)

Ensembl ID

ENSG00000172115  (ver. 103.38)

Orthologs

-

UniProt

P99999

neXtProt

NX_P99999

Human splice variants

Protein structure