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- Antibody Data
- Antigen structure
- References [7]
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- Product number
- AP8437b - Provider product page
- Provider
- Abgent
- Proper citation
- Abgent Cat#AP8437b, RRID:AB_2169914
- Product name
- PPM1D Antibody (C-term)
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- Purified Rabbit Polyclonal Antibody (Pab)
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 400 µl
- Concentration
- 2 mg/ml
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors.
Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.
The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.
The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression.
Park JY, Song JY, Kim HM, Han HS, Seol HS, Jang SJ, Choi J
The international journal of biochemistry & cell biology 2012 Jun;44(6):896-904
The international journal of biochemistry & cell biology 2012 Jun;44(6):896-904
Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.
Zhang X, Wan G, Mlotshwa S, Vance V, Berger FG, Chen H, Lu X
Cancer research 2010 Sep 15;70(18):7176-86
Cancer research 2010 Sep 15;70(18):7176-86
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.
Song JY, Han HS, Sabapathy K, Lee BM, Yu E, Choi J
The Journal of biological chemistry 2010 Mar 19;285(12):9067-76
The Journal of biological chemistry 2010 Mar 19;285(12):9067-76
The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
Nguyen TA, Slattery SD, Moon SH, Darlington YF, Lu X, Donehower LA
DNA repair 2010 Jul 1;9(7):813-23
DNA repair 2010 Jul 1;9(7):813-23
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA
The Journal of biological chemistry 2010 Apr 23;285(17):12935-47
The Journal of biological chemistry 2010 Apr 23;285(17):12935-47
Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.
Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X
Cancer research 2009 Oct 15;69(20):7960-8
Cancer research 2009 Oct 15;69(20):7960-8
The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression.
Han HS, Yu E, Song JY, Park JY, Jang SJ, Choi J
Molecular cancer research : MCR 2009 May;7(5):713-23
Molecular cancer research : MCR 2009 May;7(5):713-23
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Supportive validation
- Submitted by
- Abgent (provider)
- Main image
- Experimental details
- The anti-PPM1D Pab (Cat. #AP8437b) is used in Western blot to detect PPM1D in 293 cell lysate.
- Primary Ab dilution
- 1:1000
