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Cell line expression
Protein structure
PPM1D
Protein phosphatase, Mg2+/Mn2+ dependent 1DPP2C-DELTA, Wip1
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| GeneTex |  GTX31604 |
Polyclonal |
WB
EL
ICC
IHC
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| Boster Biological Technology | A01576-1 |
Polyclonal |
WB
EL
ICC
FC
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| Proteintech Group | 67440-1-Ig |
Monoclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | 67440-1-IG |
Monoclonal |
WB
ICC
IHC
|
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| Biorbyt | orb1467381 |
Monoclonal |
WB
EL
ICC
IHC
|
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