PLA2G4A

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Description

Phospholipase A2 group IVA

Tissue specificity

Tissue enhanced (parathyroid gland, seminal vesicle)

Subcell location

Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
RAS pathway related proteins

Chromosome

1 (186828949 - 186988981)

Ensembl ID

ENSG00000116711  (ver. 103.38)

Orthologs

Mouse Pla2g4a: ENSMUSG00000056220

UniProt

P47712

neXtProt

NX_P47712

Human splice variants
Mouse splice variants

Protein structure