SPAG11A

This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Description

Sperm associated antigen 11A

Tissue specificity

Tissue enriched (epididymis)

Subcell location

Golgi apparatus

Predicted location

Intracellular, Secreted in male reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

8 (7847876 - 7868867)

Ensembl ID

ENSG00000178287  (ver. 103.38)

Orthologs

-

UniProt

Q6PDA7

neXtProt

NX_Q6PDA7

Human splice variants

Protein structure