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- Antibody Data
- Antigen structure
- References [23]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 12807-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12807-1-AP, RRID:AB_10638760
- Product name
- BACE1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BACE1 antibody (Cat. #12807-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, zebrafish, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation.
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
Modified Low-Temperature Extraction Method for Isolation of Bletilla striata Polysaccharide as Antioxidant for the Prevention of Alzheimer's Disease.
N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy.
Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.
Tetramethylpyrazine Attenuated Sevoflurane-Induced Neurotoxicity by Enhancing Autophagy through GPR50/CREB Pathway in SH-SY5Y Cells.
Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice.
Opposite Roles of δ- and μ-Opioid Receptors in BACE1 Regulation and Alzheimer's Injury.
Activating transcription factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice.
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
p35 Hemizygous Deletion in 5xFAD Mice Increases Aβ Plaque Load in Males but Not in Females.
Brain-derived neurotrophic factor modified human umbilical cord mesenchymal stem cells-derived cholinergic-like neurons improve spatial learning and memory ability in Alzheimer's disease rats.
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.
Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.
Effects of chain length of saturated fatty acids on Aβ generation in SH-SY5Y cells.
Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease.
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.
BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus.
Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.
Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer's disease.
Quercetin reduces eIF2α phosphorylation by GADD34 induction.
Aβ-induced Golgi fragmentation in Alzheimer's disease enhances Aβ production.
Xu Y, Dong Y, Wang C, Jiang Q, Chu H, Tian Y
Neurochemistry international 2021 Sep;148:105078
Neurochemistry international 2021 Sep;148:105078
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
Inoue Y, Masuda T, Misumi Y, Ando Y, Ueda M
Neuroscience letters 2021 Sep 25;762:136136
Neuroscience letters 2021 Sep 25;762:136136
Modified Low-Temperature Extraction Method for Isolation of Bletilla striata Polysaccharide as Antioxidant for the Prevention of Alzheimer's Disease.
Lin YW, Fang CH, Liang YJ, Liao HH, Lin FH
International journal of molecular sciences 2021 Nov 25;22(23)
International journal of molecular sciences 2021 Nov 25;22(23)
N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy.
Long CM, Zheng QX, Zhou Y, Liu YT, Gong LP, Zeng YC, Liu S
Journal of pharmacological sciences 2021 Dec;147(4):315-324
Journal of pharmacological sciences 2021 Dec;147(4):315-324
Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.
Wang X, Yang G
Cell biology international 2021 Apr;45(4):775-784
Cell biology international 2021 Apr;45(4):775-784
Tetramethylpyrazine Attenuated Sevoflurane-Induced Neurotoxicity by Enhancing Autophagy through GPR50/CREB Pathway in SH-SY5Y Cells.
Xu L, Shen J, Dai S, Sun L, Chen X
The American journal of Chinese medicine 2020;48(4):945-966
The American journal of Chinese medicine 2020;48(4):945-966
Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice.
Ha L, Yang B, Wang S, An Y, Wang H, Cui Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3598930
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3598930
Opposite Roles of δ- and μ-Opioid Receptors in BACE1 Regulation and Alzheimer's Injury.
Xu Y, Zhi F, Balboni G, Yang Y, Xia Y
Frontiers in cellular neuroscience 2020;14:88
Frontiers in cellular neuroscience 2020;14:88
Activating transcription factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice.
Du Y, Liu X, Zhu X, Liu Y, Wang X, Wu X
The International journal of neuroscience 2020 Oct;130(10):1015-1023
The International journal of neuroscience 2020 Oct;130(10):1015-1023
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M, Liu R
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103
p35 Hemizygous Deletion in 5xFAD Mice Increases Aβ Plaque Load in Males but Not in Females.
Barrett T, Marchalant Y, Park KHJ
Neuroscience 2019 Oct 1;417:45-56
Neuroscience 2019 Oct 1;417:45-56
Brain-derived neurotrophic factor modified human umbilical cord mesenchymal stem cells-derived cholinergic-like neurons improve spatial learning and memory ability in Alzheimer's disease rats.
Hu W, Feng Z, Xu J, Jiang Z, Feng M
Brain research 2019 May 1;1710:61-73
Brain research 2019 May 1;1710:61-73
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.
Inoue Y, Ueda M, Masuda T, Misumi Y, Yamashita T, Ando Y
Molecular neurobiology 2019 Dec;56(12):8573-8588
Molecular neurobiology 2019 Dec;56(12):8573-8588
Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.
Zhang Y, Xie JZ, Xu XY, Hu J, Xu T, Jin S, Yang SJ, Wang JZ
Neuroscience bulletin 2019 Aug;35(4):724-734
Neuroscience bulletin 2019 Aug;35(4):724-734
Effects of chain length of saturated fatty acids on Aβ generation in SH-SY5Y cells.
Liu JJ, Zhang W, Wang SS, Jia ZQ, Shi YH, Yang L, Shi RL
Neuroscience letters 2019 Apr 17;698:169-172
Neuroscience letters 2019 Apr 17;698:169-172
Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease.
Zhao YS, Zhang LH, Yu PP, Gou YJ, Zhao J, You LH, Wang ZY, Zheng X, Yan LJ, Yu P, Chang YZ
Antioxidants & redox signaling 2018 May 10;28(14):1323-1337
Antioxidants & redox signaling 2018 May 10;28(14):1323-1337
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.
Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY, Liu R
Cell reports 2018 Jul 17;24(3):713-723
Cell reports 2018 Jul 17;24(3):713-723
BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus.
Hou H, Fan Q, He W, Suh H, Hu X, Yan R
Stem cell reports 2017 Jul 11;9(1):217-230
Stem cell reports 2017 Jul 11;9(1):217-230
Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.
Wang XF, Liu DX, Liang Y, Xing LL, Zhao WH, Qin XX, Shang DS, Li B, Fang WG, Cao L, Zhao WD, Chen YH
PloS one 2016;11(8):e0161093
PloS one 2016;11(8):e0161093
Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer's disease.
Zhang Y, Yang X, Jin G, Yang X, Zhang Y
International journal of biological macromolecules 2016 Nov;92:935-941
International journal of biological macromolecules 2016 Nov;92:935-941
Quercetin reduces eIF2α phosphorylation by GADD34 induction.
Hayakawa M, Itoh M, Ohta K, Li S, Ueda M, Wang MX, Nishida E, Islam S, Suzuki C, Ohzawa K, Kobori M, Inuzuka T, Nakagawa T
Neurobiology of aging 2015 Sep;36(9):2509-18
Neurobiology of aging 2015 Sep;36(9):2509-18
Aβ-induced Golgi fragmentation in Alzheimer's disease enhances Aβ production.
Joshi G, Chi Y, Huang Z, Wang Y
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 1;111(13):E1230-9
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 1;111(13):E1230-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 12807-1-AP(BACE1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-BACE1 (IP:12807-1-AP, 3ug; Detection:12807-1-AP 1:500) with mouse brain tissue lysate 7500ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BACE1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BACE1. This antibody recognizes human, mouse, zebrafish antigen. The BACE1 antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.
