CABT-L524

antibody from Creative Diagnostics

Targeting: BACE1 BACE

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-L524

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human BACE1 Polyclonal Antibody

Antibody type

Polyclonal

Description

ÉÇ-secretase, also called BACE (ÉÇ-site of APP cleaving enzyme), is an aspartic-acid protease important in the pathogenesis of Alzheimers disease, and in the formation of myelin sheaths in peripheral nerve cells. BACE1, also known as memapsin-2, is the major ÉÇ-secretase for generation of the 40 or 42 amino acid-long ÉÇ-amyloid peptides that aggregate in the brain of Alzheimers patients. Extracellular cleavage of APP by BACE1 releases a soluble extracellular fragment and is followed by APP cleavage within its transmembrane domain by ÎÛ-secretase. The second cleavage releases the intracellular domain of APP and ÉÇ-amyloid.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

40 _g

Concentration

Lot specific

Storage

The antibody is stable for 2-3 weeks if stored at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.