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Immunoprecipitation
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- MAB9311 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse BACE-1 Ectodomain Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human and mouse BACE-1 Ectodomain in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) BACE-2, recombinant mouse BACE-2, rhADAM8, rhADAM9, rhADAM10, rhADAM15, or rhTACE is observed.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
P56817- Isotype
- IgG
- Antibody clone number
- 137626
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.
Costantini C, Ko MH, Jonas MC, Puglielli L
The Biochemical journal 2007 Nov 1;407(3):383-95
The Biochemical journal 2007 Nov 1;407(3):383-95
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Neutralization of BACE-1 Activity by Human/Mouse BACE-1 Antibody. The cleavage of Mca-SEVNLDAEFRK(Dnp)RR-NH2 (10 µM, Catalog # ES004) by Recombinant Human BACE-1 (10 µg/mL, Catalog # 931-AS) or Recombinant Mouse BACE-1 (10 µg/mL, Catalog # 2976-AS) is measured after preincubation with increasing concentrations of Mouse Anti-Human/Mouse BACE-1 Ectodomain Monoclonal Antibody (Catalog # MAB9311). The ND50 is typically 10 µg/mL.a
