CREM

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]

Description

CAMP responsive element modulator

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

10:p11.21 (35126791 - 35212958)

Ensembl ID

ENSG00000095794  (ver. 103.38)

Orthologs

Mouse Crem: ENSMUSG00000063889

UniProt

Q03060

neXtProt

NX_Q03060

Human splice variants
Mouse splice variants