Tissue expression
Cell line expression
CREM
gene producthCREM-2
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
- Description
- CAMP responsive element modulator
- Tissue specificity
- Tissue enhanced (testis)
- Subcell location
- Nucleoplasm, Vesicles
- Predicted location
- Intracellular
- Protein family
- Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors
- Chromosome
- 10:p11.21 (35126791 - 35212958)
- Ensembl ID
- ENSG00000095794 (ver. 103.38)
- Orthologs
- Mouse Crem: ENSMUSG00000063889
- UniProt
- Q03060
- neXtProt
- NX_Q03060
Human splice variants
Mouse splice variants
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.
Featured antibodies
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0 references | Polyclonal |
WB
IHC |