U2AF2

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

Description

U2 small nuclear RNA auxiliary factor 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear speckles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (55654146 - 55674716)

Ensembl ID

ENSG00000063244  (ver. 103.38)

Orthologs

Mouse U2af2: ENSMUSG00000030435

UniProt

P26368

neXtProt

NX_P26368

Human splice variants
Mouse splice variants

Protein structure