Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13690-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13690-1-AP, RRID:AB_2149326
- Product name
- NEDD4L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NEDD4L antibody (Cat. #13690-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PTENα is responsible for protection of brain against oxidative stress during aging.
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Exosomes Derived From Macrophages Enhance Aerobic Glycolysis and Chemoresistance in Lung Cancer by Stabilizing c-Myc via the Inhibition of NEDD4L.
JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling.
The correlation between NEDD4L and HIF-1α levels as a gastric cancer prognostic marker.
USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation.
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Wang P, Li R, Yuan Y, Zhu M, Liu Y, Jin Y, Yin Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21943
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21943
Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.
Huo L, Gao Y, Zhang D, Wang S, Han Y, Men H, Yang Z, Qin X, Wang R, Kong D, Bai H, Zhang H, Zhang W, Jia Z
Pharmacological research 2021 Feb;164:105391
Pharmacological research 2021 Feb;164:105391
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C, Wu B, Chen Y, Li X, Bai Y, Du Y, Pang Y, Wang YT, Dong Z
Cell death and differentiation 2021 Aug;28(8):2367-2384
Cell death and differentiation 2021 Aug;28(8):2367-2384
Exosomes Derived From Macrophages Enhance Aerobic Glycolysis and Chemoresistance in Lung Cancer by Stabilizing c-Myc via the Inhibition of NEDD4L.
Wang H, Wang L, Pan H, Wang Y, Shi M, Yu H, Wang C, Pan X, Chen Z
Frontiers in cell and developmental biology 2020;8:620603
Frontiers in cell and developmental biology 2020;8:620603
JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling.
Cui J, Shu C, Xu J, Chen D, Li J, Ding K, Chen M, Li A, He J, Shu Y, Yang L, Zhang R, Zhou J
Theranostics 2020;10(18):8036-8050
Theranostics 2020;10(18):8036-8050
The correlation between NEDD4L and HIF-1α levels as a gastric cancer prognostic marker.
Jiang X, Zhang S, Yin Z, Sheng Y, Yan Q, Sun R, Lu M, Zhang Z, Li Y
International journal of medical sciences 2019;16(11):1517-1524
International journal of medical sciences 2019;16(11):1517-1524
USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X, Qian Y
The Journal of experimental medicine 2018 Nov 5;215(11):2850-2867
The Journal of experimental medicine 2018 Nov 5;215(11):2850-2867
Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.
Zhu B, Das S, Mitra S, Farris TR, McBride JW
Infection and immunity 2017 Sep;85(9)
Infection and immunity 2017 Sep;85(9)
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Broix L, Jagline H, Ivanova E, Schmucker S, Drouot N, Clayton-Smith J, Pagnamenta AT, Metcalfe KA, Isidor B, Louvier UW, Poduri A, Taylor JC, Tilly P, Poirier K, Saillour Y, Lebrun N, Stemmelen T, Rudolf G, Muraca G, Saintpierre B, Elmorjani A, Deciphering Developmental Disorders study., Moïse M, Weirauch NB, Guerrini R, Boland A, Olaso R, Masson C, Tripathy R, Keays D, Beldjord C, Nguyen L, Godin J, Kini U, Nischké P, Deleuze JF, Bahi-Buisson N, Sumara I, Hinckelmann MV, Chelly J
Nature genetics 2016 Nov;48(11):1349-1358
Nature genetics 2016 Nov;48(11):1349-1358
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Li Z, Li J, Bi P, Lu Y, Burcham G, Elzey BD, Ratliff T, Konieczny SF, Ahmad N, Kuang S, Liu X
Molecular and cellular biology 2014 Oct 1;34(19):3642-61
Molecular and cellular biology 2014 Oct 1;34(19):3642-61
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Kito Y, Bai J, Goto N, Okubo H, Adachi Y, Nagayama T, Takeuchi T
International journal of experimental pathology 2014 Feb;95(1):24-8
International journal of experimental pathology 2014 Feb;95(1):24-8
Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
Jung S, Li C, Jeong D, Lee S, Ohk J, Park M, Han S, Duan J, Kim C, Yang Y, Kim KI, Lim JS, Kang YS, Lee MS
International journal of oncology 2013 Nov;43(5):1587-95
International journal of oncology 2013 Nov;43(5):1587-95
YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation.
Skouloudaki K, Walz G
PloS one 2012;7(4):e35735
PloS one 2012;7(4):e35735
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Gao C, Pang L, Ren C, Ma T
Medical oncology (Northwood, London, England) 2012 Sep;29(3):1733-8
Medical oncology (Northwood, London, England) 2012 Sep;29(3):1733-8
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Takeuchi T, Adachi Y, Nagayama T, Furihata M
International journal of experimental pathology 2011 Apr;92(2):79-86
International journal of experimental pathology 2011 Apr;92(2):79-86
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 13690-1-AP(NEDD4L antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 13690-1-AP(NEDD4L antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NEDD4L antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NEDD4L. This antibody recognizes human,mouse,rat antigen. The NEDD4L antibody has been validated for the following applications: ELISA, WB, IHC analysis.