Antibody data

Product number
BS60620
Provider
Bioworld Technology, Inc
Product name
IL3RA polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS60620
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human IL3RA
Description
Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific Ï« subunit (IL-3RÏ«) and a signal transducing ÉÇ subunit (IL-3RÉÇ) common to the IL-3/IL-5/GM-CSF receptors. The Ï« subunits are low-affinity ligand-binding proteins while the ÉÇ subunits do not themselves bind ligand, but are required for high affinity binding by the Ï« subunits. The mouse IL-3 receptor has two distinct ÉÇ subunits, one that functions only in IL-3-mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine ÉÇ subunits are 91% homologous at the amino acid level but only 56% homologous to the human ÉÇ subunit. The carboxy-terminus of the ÉÇ subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Provider Type Product Number
- No reagents -