IL3RA

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Description

Interleukin 3 receptor subunit alpha

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Membrane

Protein family

CD markers
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

X (1336616 - 1382689)

Ensembl ID

ENSG00000185291  (ver. 103.38)

Orthologs

-

UniProt

P26951

neXtProt

NX_P26951

Human splice variants

Protein structure