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antibody from Novus Biologicals
Targeting: APEX1
APE, APE-1, APEN, APEX, APX, HAP1, REF-1, REF1
Western blot
Immunocytochemistry Immunoprecipitation Immunohistochemistry Blocking/Neutralizing Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [1]
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- Product number
- NB100-101 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-101, RRID:AB_10077976
- Product name
- Rabbit Polyclonal APE Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Rabbit, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.
Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma.
The long noncoding RNA ROCKI regulates inflammatory gene expression.
Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance.
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.
DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.
Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.
Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen.
Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.
p53 coordinates base excision repair to prevent genomic instability.
Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice.
E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.
Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo.
TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.
Down-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) in spinal motor neurones under oxidative stress.
Genistein alleviates radiation-induced pneumonitis by depressing Ape1/Ref-1 expression to down-regulate inflammatory cytokines.
Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer.
5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells.
A novel role for Gadd45α in base excision repair: modulation of APE1 activity by the direct interaction of Gadd45α with PCNA.
APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.
Expression pattern of apurinic/apyrimidinic endonuclease in sinonasal squamous cell carcinoma.
Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans.
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.
Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway.
Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth.
The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation.
Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.
Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines.
UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways.
S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.
Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.
Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses.
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma.
Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair.
Long patch base excision repair in mammalian mitochondrial genomes.
Nitric oxide initiates progression of human melanoma via a feedback loop mediated by apurinic/apyrimidinic endonuclease-1/redox factor-1, which is inhibited by resveratrol.
Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain.
Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.
Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA.
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcitabine and beta-D-arabinofuranosylcytosine).
Age-related loss of the DNA repair response following exposure to oxidative stress.
Age-related loss of the DNA repair response following exposure to oxidative stress.
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.
p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress.
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia.
Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance.
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.
Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.
Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.
Rates of base excision repair are not solely dependent on levels of initiating enzymes.
Rates of base excision repair are not solely dependent on levels of initiating enzymes.
Mitochondrial localization of APE/Ref-1 in thyroid cells.
Mitochondrial localization of APE/Ref-1 in thyroid cells.
Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1.
Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice.
Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice.
Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis.
Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis.
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Quiñones JL, Thapar U, Wilson SH, Ramsden DA, Demple B
DNA repair 2020 Mar;87:102773
DNA repair 2020 Mar;87:102773
Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma.
Pascut D, Sukowati CHC, Antoniali G, Mangiapane G, Burra S, Mascaretti LG, Buonocore MR, Crocè LS, Tiribelli C, Tell G
Oncotarget 2019 Jan 8;10(3):383-394
Oncotarget 2019 Jan 8;10(3):383-394
The long noncoding RNA ROCKI regulates inflammatory gene expression.
Zhang Q, Chao TC, Patil VS, Qin Y, Tiwari SK, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton KJ, Rana TM
The EMBO journal 2019 Apr 15;38(8)
The EMBO journal 2019 Apr 15;38(8)
Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance.
Kumar S, Talluri S, Pal J, Yuan X, Lu R, Nanjappa P, Samur MK, Munshi NC, Shammas MA
Blood cancer journal 2018 Sep 25;8(10):92
Blood cancer journal 2018 Sep 25;8(10):92
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.
Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML
Scientific reports 2018 Sep 13;8(1):13759
Scientific reports 2018 Sep 13;8(1):13759
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.
Shah F, Logsdon D, Messmann RA, Fehrenbacher JC, Fishel ML, Kelley MR
NPJ precision oncology 2017;1
NPJ precision oncology 2017;1
DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.
Fehrenbacher JC, Guo C, Kelley MR, Vasko MR
Neuroscience 2017 Dec 16;366:23-35
Neuroscience 2017 Dec 16;366:23-35
Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.
Logsdon DP, Grimard M, Luo M, Shahda S, Jiang Y, Tong Y, Yu Z, Zyromski N, Schipani E, Carta F, Supuran CT, Korc M, Ivan M, Kelley MR, Fishel ML
Molecular cancer therapeutics 2016 Nov;15(11):2722-2732
Molecular cancer therapeutics 2016 Nov;15(11):2722-2732
Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen.
Sandomenico A, Focà A, Sanguigno L, Caporale A, Focà G, Pignalosa A, Corvino G, Caragnano A, Beltrami AP, Antoniali G, Tell G, Leonardi A, Ruvo M
mAbs 2016 Nov Dec;8(8):1575-1589
mAbs 2016 Nov Dec;8(8):1575-1589
Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.
Nassour H, Wang Z, Saad A, Papaluca A, Brosseau N, Affar el B, Alaoui-Jamali MA, Ramotar D
Scientific reports 2016 Jul 8;6:29389
Scientific reports 2016 Jul 8;6:29389
p53 coordinates base excision repair to prevent genomic instability.
Poletto M, Legrand AJ, Fletcher SC, Dianov GL
Nucleic acids research 2016 Apr 20;44(7):3165-75
Nucleic acids research 2016 Apr 20;44(7):3165-75
Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice.
Sanchez JR, Reddick TL, Perez M, Centonze VE, Mitra S, Izumi T, McMahan CA, Walter CA
Mutation research 2015 Sep;779:124-33
Mutation research 2015 Sep;779:124-33
E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.
Iglesias-Ara A, Zenarruzabeitia O, Buelta L, Merino J, Zubiaga AM
Cell death and differentiation 2015 Oct;22(10):1577-89
Cell death and differentiation 2015 Oct;22(10):1577-89
Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo.
Quiñones JL, Thapar U, Yu K, Fang Q, Sobol RW, Demple B
Proceedings of the National Academy of Sciences of the United States of America 2015 Jul 14;112(28):8602-7
Proceedings of the National Academy of Sciences of the United States of America 2015 Jul 14;112(28):8602-7
TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.
Alagoz M, Wells OS, El-Khamisy SF
Nucleic acids research 2014 Mar;42(5):3089-103
Nucleic acids research 2014 Mar;42(5):3089-103
Down-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) in spinal motor neurones under oxidative stress.
Chu TH, Guo A, Wu W
Neuropathology and applied neurobiology 2014 Jun;40(4):435-51
Neuropathology and applied neurobiology 2014 Jun;40(4):435-51
Genistein alleviates radiation-induced pneumonitis by depressing Ape1/Ref-1 expression to down-regulate inflammatory cytokines.
Liu GD, Xia L, Zhu JW, Ou S, Li MX, He Y, Luo W, Li J, Zhou Q, Yang XQ, Shan JL, Wang G, Wang D, Yang ZZ
Cell biochemistry and biophysics 2014 Jul;69(3):725-33
Cell biochemistry and biophysics 2014 Jul;69(3):725-33
Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer.
Abdel-Fatah TM, Perry C, Moseley P, Johnson K, Arora A, Chan S, Ellis IO, Madhusudan S
Breast cancer research and treatment 2014 Feb;143(3):411-21
Breast cancer research and treatment 2014 Feb;143(3):411-21
5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.
Das D, Preet R, Mohapatra P, Satapathy SR, Siddharth S, Tamir T, Jain V, Bharatam PV, Wyatt MD, Kundu CN
DNA repair 2014 Dec;24:15-25
DNA repair 2014 Dec;24:15-25
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Abdel-Fatah TM, Perry C, Arora A, Thompson N, Doherty R, Moseley PM, Green AR, Chan SY, Ellis IO, Madhusudan S
Antioxidants & redox signaling 2014 Dec 1;21(16):2262-8
Antioxidants & redox signaling 2014 Dec 1;21(16):2262-8
1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells.
Das D, Preet R, Mohapatra P, Satapathy SR, Kundu CN
World journal of gastroenterology 2013 Nov 14;19(42):7374-88
World journal of gastroenterology 2013 Nov 14;19(42):7374-88
A novel role for Gadd45α in base excision repair: modulation of APE1 activity by the direct interaction of Gadd45α with PCNA.
Kim HL, Kim SU, Seo YR
Biochemical and biophysical research communications 2013 May 3;434(2):185-90
Biochemical and biophysical research communications 2013 May 3;434(2):185-90
APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.
Cardoso AA, Jiang Y, Luo M, Reed AM, Shahda S, He Y, Maitra A, Kelley MR, Fishel ML
PloS one 2012;7(10):e47462
PloS one 2012;7(10):e47462
Expression pattern of apurinic/apyrimidinic endonuclease in sinonasal squamous cell carcinoma.
Lee JW, Jin J, Rha KS, Kim YM
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2012 Oct;147(4):788-95
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2012 Oct;147(4):788-95
Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.
Sultana R, McNeill DR, Abbotts R, Mohammed MZ, Zdzienicka MZ, Qutob H, Seedhouse C, Laughton CA, Fischer PM, Patel PM, Wilson DM 3rd, Madhusudan S
International journal of cancer 2012 Nov 15;131(10):2433-44
International journal of cancer 2012 Nov 15;131(10):2433-44
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
Kadekaro AL, Chen J, Yang J, Chen S, Jameson J, Swope VB, Cheng T, Kadakia M, Abdel-Malek Z
Molecular cancer research : MCR 2012 Jun;10(6):778-86
Molecular cancer research : MCR 2012 Jun;10(6):778-86
APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans.
McManus F, Sands W, Diver L, MacKenzie SM, Fraser R, Davies E, Connell JM
Circulation research 2012 Jul 6;111(2):212-9
Circulation research 2012 Jul 6;111(2):212-9
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.
Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14007-12
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14007-12
Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway.
Juliana FM, Nara H, Onoda T, Rahman M, Araki A, Jin L, Fujii H, Tanaka N, Hoshino T, Asao H
Biochemical and biophysical research communications 2012 Apr 13;420(3):628-34
Biochemical and biophysical research communications 2012 Apr 13;420(3):628-34
Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth.
Fishel ML, Jiang Y, Rajeshkumar NV, Scandura G, Sinn AL, He Y, Shen C, Jones DR, Pollok KE, Ivan M, Maitra A, Kelley MR
Molecular cancer therapeutics 2011 Sep;10(9):1698-708
Molecular cancer therapeutics 2011 Sep;10(9):1698-708
The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation.
Vasko MR, Guo C, Thompson EL, Kelley MR
DNA repair 2011 Sep 5;10(9):942-52
DNA repair 2011 Sep 5;10(9):942-52
Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.
La Maestra S, Kisby GE, Micale RT, Johnson J, Kow YW, Bao G, Sheppard C, Stanfield S, Tran H, Woltjer RL, D'Agostini F, Steele VE, De Flora S
Toxicological sciences : an official journal of the Society of Toxicology 2011 Oct;123(2):471-9
Toxicological sciences : an official journal of the Society of Toxicology 2011 Oct;123(2):471-9
Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines.
Mohammed MZ, Vyjayanti VN, Laughton CA, Dekker LV, Fischer PM, Wilson DM 3rd, Abbotts R, Shah S, Patel PM, Hickson ID, Madhusudan S
British journal of cancer 2011 Feb 15;104(4):653-63
British journal of cancer 2011 Feb 15;104(4):653-63
UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways.
Vrouwe MG, Pines A, Overmeer RM, Hanada K, Mullenders LH
Journal of cell science 2011 Feb 1;124(Pt 3):435-46
Journal of cell science 2011 Feb 1;124(Pt 3):435-46
S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.
Kim YJ, Kim D, Illuzzi JL, Delaplane S, Su D, Bernier M, Gross ML, Georgiadis MM, Wilson DM 3rd
Journal of molecular biology 2011 Dec 2;414(3):313-26
Journal of molecular biology 2011 Dec 2;414(3):313-26
Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.
Al-Attar A, Gossage L, Fareed KR, Shehata M, Mohammed M, Zaitoun AM, Soomro I, Lobo DN, Abbotts R, Chan S, Madhusudan S
British journal of cancer 2010 Feb 16;102(4):704-9
British journal of cancer 2010 Feb 16;102(4):704-9
Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses.
Lee HM, Yuk JM, Shin DM, Yang CS, Kim KK, Choi DK, Liang ZL, Kim JM, Jeon BH, Kim CD, Lee JH, Jo EK
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 15;183(10):6839-48
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 15;183(10):6839-48
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Yan T, Seo Y, Kinsella TJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma.
Lam W, Bussom S, Cheng YC
Molecular cancer therapeutics 2009 Feb;8(2):415-23
Molecular cancer therapeutics 2009 Feb;8(2):415-23
Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair.
Wang S, Xing Z, Vosler PS, Yin H, Li W, Zhang F, Signore AP, Stetler RA, Gao Y, Chen J
Stroke 2008 Sep;39(9):2587-95
Stroke 2008 Sep;39(9):2587-95
Long patch base excision repair in mammalian mitochondrial genomes.
Szczesny B, Tann AW, Longley MJ, Copeland WC, Mitra S
The Journal of biological chemistry 2008 Sep 26;283(39):26349-56
The Journal of biological chemistry 2008 Sep 26;283(39):26349-56
Nitric oxide initiates progression of human melanoma via a feedback loop mediated by apurinic/apyrimidinic endonuclease-1/redox factor-1, which is inhibited by resveratrol.
Yang Z, Yang S, Misner BJ, Chiu R, Liu F, Meyskens FL Jr
Molecular cancer therapeutics 2008 Dec;7(12):3751-60
Molecular cancer therapeutics 2008 Dec;7(12):3751-60
Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Raffoul JJ, Banerjee S, Singh-Gupta V, Knoll ZE, Fite A, Zhang H, Abrams J, Sarkar FH, Hillman GG
Cancer research 2007 Mar 1;67(5):2141-9
Cancer research 2007 Mar 1;67(5):2141-9
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain.
Zou GM, Luo MH, Reed A, Kelley MR, Yoder MC
Blood 2007 Mar 1;109(5):1917-22
Blood 2007 Mar 1;109(5):1917-22
Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.
Briegert M, Kaina B
Cancer research 2007 Jan 1;67(1):26-31
Cancer research 2007 Jan 1;67(1):26-31
Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA.
Yang B, Chen K, Zhang C, Huang S, Zhang H
The Journal of biological chemistry 2007 Apr 20;282(16):11667-75
The Journal of biological chemistry 2007 Apr 20;282(16):11667-75
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Akbari M, Otterlei M, Peña-Diaz J, Krokan HE
Neuroscience 2007 Apr 14;145(4):1201-12
Neuroscience 2007 Apr 14;145(4):1201-12
Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcitabine and beta-D-arabinofuranosylcytosine).
Lam W, Park SY, Leung CH, Cheng YC
Molecular pharmacology 2006 May;69(5):1607-14
Molecular pharmacology 2006 May;69(5):1607-14
Age-related loss of the DNA repair response following exposure to oxidative stress.
Cabelof DC, Raffoul JJ, Ge Y, Van Remmen H, Matherly LH, Heydari AR
The journals of gerontology. Series A, Biological sciences and medical sciences 2006 May;61(5):427-34
The journals of gerontology. Series A, Biological sciences and medical sciences 2006 May;61(5):427-34
Age-related loss of the DNA repair response following exposure to oxidative stress.
Cabelof DC, Raffoul JJ, Ge Y, Van Remmen H, Matherly LH, Heydari AR
The journals of gerontology. Series A, Biological sciences and medical sciences 2006 May;61(5):427-34
The journals of gerontology. Series A, Biological sciences and medical sciences 2006 May;61(5):427-34
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.
O'Hara AM, Bhattacharyya A, Mifflin RC, Smith MF, Ryan KA, Scott KG, Naganuma M, Casola A, Izumi T, Mitra S, Ernst PB, Crowe SE
Journal of immunology (Baltimore, Md. : 1950) 2006 Dec 1;177(11):7990-9
Journal of immunology (Baltimore, Md. : 1950) 2006 Dec 1;177(11):7990-9
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.
O'Hara AM, Bhattacharyya A, Mifflin RC, Smith MF, Ryan KA, Scott KG, Naganuma M, Casola A, Izumi T, Mitra S, Ernst PB, Crowe SE
Journal of immunology (Baltimore, Md. : 1950) 2006 Dec 1;177(11):7990-9
Journal of immunology (Baltimore, Md. : 1950) 2006 Dec 1;177(11):7990-9
p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress.
O'reilly MA, Vitiello PF, Gehen SC, Staversky RJ
Antioxidants & redox signaling 2005 May-Jun;7(5-6):719-25
Antioxidants & redox signaling 2005 May-Jun;7(5-6):719-25
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Akbari M, Otterlei M, Peña-Diaz J, Aas PA, Kavli B, Liabakk NB, Hagen L, Imai K, Durandy A, Slupphaug G, Krokan HE
Nucleic acids research 2004;32(18):5486-98
Nucleic acids research 2004;32(18):5486-98
MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia.
Takahashi G, Sakurai M, Abe K, Itoyama Y, Tabayashi K
The Annals of thoracic surgery 2004 Aug;78(2):602-7
The Annals of thoracic surgery 2004 Aug;78(2):602-7
Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance.
Freitas S, Moore DH, Michael H, Kelley MR
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Oct 15;9(13):4689-94
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Oct 15;9(13):4689-94
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.
Silber JR, Bobola MS, Blank A, Schoeler KD, Haroldson PD, Huynh MB, Kolstoe DD
Clinical cancer research : an official journal of the American Association for Cancer Research 2002 Sep;8(9):3008-18
Clinical cancer research : an official journal of the American Association for Cancer Research 2002 Sep;8(9):3008-18
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.
Bobola MS, Blank A, Berger MS, Stevens BA, Silber JR
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Nov;7(11):3510-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Nov;7(11):3510-8
Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.
Taverna P, Liu L, Hwang HS, Hanson AJ, Kinsella TJ, Gerson SL
Mutation research 2001 May 10;485(4):269-81
Mutation research 2001 May 10;485(4):269-81
Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.
Taverna P, Liu L, Hwang HS, Hanson AJ, Kinsella TJ, Gerson SL
Mutation research 2001 May 10;485(4):269-81
Mutation research 2001 May 10;485(4):269-81
Rates of base excision repair are not solely dependent on levels of initiating enzymes.
Cappelli E, Hazra T, Hill JW, Slupphaug G, Bogliolo M, Frosina G
Carcinogenesis 2001 Mar;22(3):387-93
Carcinogenesis 2001 Mar;22(3):387-93
Rates of base excision repair are not solely dependent on levels of initiating enzymes.
Cappelli E, Hazra T, Hill JW, Slupphaug G, Bogliolo M, Frosina G
Carcinogenesis 2001 Mar;22(3):387-93
Carcinogenesis 2001 Mar;22(3):387-93
Mitochondrial localization of APE/Ref-1 in thyroid cells.
Tell G, Crivellato E, Pines A, Paron I, Pucillo C, Manzini G, Bandiera A, Kelley MR, Di Loreto C, Damante G
Mutation research 2001 Mar 7;485(2):143-52
Mutation research 2001 Mar 7;485(2):143-52
Mitochondrial localization of APE/Ref-1 in thyroid cells.
Tell G, Crivellato E, Pines A, Paron I, Pucillo C, Manzini G, Bandiera A, Kelley MR, Di Loreto C, Damante G
Mutation research 2001 Mar 7;485(2):143-52
Mutation research 2001 Mar 7;485(2):143-52
Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1.
Kelley MR, Parsons SH
Antioxidants & redox signaling 2001 Aug;3(4):671-83
Antioxidants & redox signaling 2001 Aug;3(4):671-83
Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice.
Morita-Fujimura Y, Fujimura M, Kawase M, Chan PH
Neuroscience 1999;93(4):1465-73
Neuroscience 1999;93(4):1465-73
Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice.
Morita-Fujimura Y, Fujimura M, Kawase M, Chan PH
Neuroscience 1999;93(4):1465-73
Neuroscience 1999;93(4):1465-73
Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Fujimura M, Morita-Fujimura Y, Narasimhan P, Copin JC, Kawase M, Chan PH
Stroke 1999 Nov;30(11):2408-15
Stroke 1999 Nov;30(11):2408-15
Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Fujimura M, Morita-Fujimura Y, Narasimhan P, Copin JC, Kawase M, Chan PH
Stroke 1999 Nov;30(11):2408-15
Stroke 1999 Nov;30(11):2408-15
Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis.
Kawase M, Fujimura M, Morita-Fujimura Y, Chan PH
Stroke 1999 Feb;30(2):441-8; discussion 449
Stroke 1999 Feb;30(2):441-8; discussion 449
Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis.
Kawase M, Fujimura M, Morita-Fujimura Y, Chan PH
Stroke 1999 Feb;30(2):441-8; discussion 449
Stroke 1999 Feb;30(2):441-8; discussion 449
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Chang YY, Fujimura M, Morita-Fujimura Y, Kim GW, Huang CY, Wu HS, Kawase M, Copin JC, Chan PH
Neuroscience letters 1999 Dec 17;277(1):61-4
Neuroscience letters 1999 Dec 17;277(1):61-4
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Chang YY, Fujimura M, Morita-Fujimura Y, Kim GW, Huang CY, Wu HS, Kawase M, Copin JC, Chan PH
Neuroscience letters 1999 Dec 17;277(1):61-4
Neuroscience letters 1999 Dec 17;277(1):61-4
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: APE Antibody [NB100-101] - Lane view shows a specific band for APE1 in 0.1 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
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- Novus Biologicals (provider)
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- Western Blot: APE Antibody [NB100-101] - Analysis of APE in human melanoma cell lysate using anti-APE antibody. Image from verified customer review.
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- Novus Biologicals (provider)
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- Western Blot: APE Antibody [NB100-101] - Analysis of APE1 in cell lysates: 1. HeLa, 2. Ntera2, 3. A431, 4. HepG2, 5. MCF7, 6. NIH 3T3, 7. PC12, and 8. Cos 7.
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- Western Blot: APE Antibody [NB100-101] - SH-SY5Y (nuclear extract) tested at 1:1000 dilution. Image provided by verified customer review.
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- Novus Biologicals (provider)
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- Western Blot: APE Antibody [NB100-101] - RKO cells were subjected to scrambled siRNA (Mock) or siRNA against TDP1 (TDP1KD) and cell lysates analyzed by immunoblotting (left). Control RKO (RKOSc siRNA) and RKO cells in which TDP1 levels were depleted (RKOTDP1 siRNA) were examined for their survival following exposure to the indicated doses of MMS, as described earlier in the text (right). Increasing the load of unrepaired methylated purines by exploiting the limited availability of TDP1 alone or in combination with canonical BER factors such as APE1 provides a new synthetic lethal setting to improve the clinical outcome of temozolomide-based cancer therapy. Image collected and cropped by CiteAb from the following publication (academic.oup.com/nar/article/42/5/3089/1051107), licensed under a CC-BY licence.
Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: APE Antibody [NB100-101] - Immunohistochemical staining of APE-ref-1 in prostate cancer.
