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F13A1
Coagulation factor XIII A chainF13A
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  NBP2-59604-100ug |
Monoclonal |
WB
EL
ICC
IHC
FC
PA
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| Invitrogen Antibodies | PA5-22110 |
1 references | Polyclonal |
WB
ICC
IHC
OA
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| NSJ Bioreagents | V3499 |
Monoclonal |
WB
EL
ICC
IHC
FC
PA
OA
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| OriGene | TA800369 |
Monoclonal |
WB
ICC
IHC
FC
|
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| antibodies-online | ABIN2673006 |
Monoclonal |
WB
ICC
IP
IHC
FC
|
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