Ab112963

antibody from Aladdin Scientific Corporation

Targeting: LEF1 TCF10, TCF1ALPHA, TCF7L3

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

Ab112963

Provider

Aladdin Scientific Corporation

Product name

Recombinant LEF1 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human LEF1 Antibody, Recombinant (R02-3A4), could be used for WB, ICC, IF and so on.Application:WB: 1/500 - 1/1000ICC/IF: 1/50 - 1/200Protein FunctionParticipates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Reactivity

Human, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 269-282


Antibody clone number

R02-3A4

Vial size

100μl,10μl,1ml,50μl

Concentration

0,1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.