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LearnTissue expression
Cell line expression
Protein structure
ILF3
Interleukin enhancer binding factor 3DRBP76, MPHOSPH4, MPP4, MPP4110, NF110, NF110b, NF90, NF90a, NF90c, NF90ctv, NFAR-1, NFAR-2, NFAR110, NFAR90, TCP110
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2014]
Top validated antibodies |
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| Proteintech Group |  19887-1-AP |
17 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 19887-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| Novus Biologicals | NBP2-75540 |
Monoclonal |
WB
ICC
IP
IHC
FC
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| Boster Biological Technology | A02313-2 |
Polyclonal |
WB
ICC
IP
IHC
FC
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| Atlas Antibodies | HPA001897 |
2 references | Polyclonal |
WB
ICC
IHC
|
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