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Protein structure
TWIST1
Twist family bHLH transcription factor 1ACS3, bHLHa38, BPES2, BPES3, CRS, CRS1, H-twist, SCS, TWIST
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Jul 2020]
Top validated antibodies |
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| Novus Biologicals |  NBP2-37364 |
4 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Proteintech Group | 25465-1-AP |
98 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN1724845 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX60776 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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| Invitrogen Antibodies | MA5-38652 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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