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AKAP12
A-kinase anchoring protein 12AKAP250, SSeCKS
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-21759 |
3 references | Polyclonal |
WB
ICC
IHC
OA
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| Boster Biological Technology | A02303-3 |
1 references | Polyclonal |
WB
EL
ICC
IHC
FC
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| LSBio | LS-B10829 |
Polyclonal |
WB
ICC
IHC
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| NSJ Bioreagents | RQ5698 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Proteintech Group | 25199-1-AP |
10 references | Polyclonal |
WB
EL
IHC
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