Tissue expression
Cell line expression
Protein structure
AFP
Alpha fetoproteinFETA, HPAFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019]
Top validated antibodies |
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Novus Biologicals | ![]() |
4 references | Monoclonal |
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Proteintech Group | ![]() |
101 references | Polyclonal |
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antibodies-online | ![]() |
5 references | Monoclonal |
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Invitrogen Antibodies | ![]() |
4 references | Polyclonal |
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Abnova Corporation | ![]() |
2 references | Monoclonal |
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