SERPING1

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

Description

serpin family G member 1

Protein family

Candidate cardiovascular disease genes, Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

11:q12.1 (57597387 - 57614848)

Ensembl ID

ENSG00000149131  (ver. 99.38)

Orthologs

Mouse Serping1: ENSMUSG00000023224

UniProt

P05155

neXtProt

NX_P05155

Human splice variants
Mouse splice variants