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LearnTissue expression
Cell line expression
Protein structure
LGMN
LegumainLGMN1, PRSC1
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Biorbyt |  orb5765 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Proteintech Group | 67017-1-Ig |
3 references | Monoclonal |
WB
EL
IHC
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| Novus Biologicals | AF2199 |
12 references | Polyclonal |
WB
IP
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| R&D Systems | AF2199 |
10 references | Polyclonal |
WB
IP
|
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| Invitrogen Antibodies | BS-3907R |
Polyclonal |
WB
EL
IHC
FC
|
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