NUDT1

gene product
MTH1
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
233 antibodies from 28 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
16 antibodies
Proteintech Group
2 antibodies
antibodies-online
78 antibodies
Invitrogen Antibodies
6 antibodies
LifeSpan BioSciences, Inc.
32 antibodies
Atlas Antibodies
1 antibody
NovoPro Bioscience Inc.
1 antibody
GeneTex
3 antibodies
Abnova Corporation
8 antibodies
St John's Laboratory
3 antibodies
Affinity Biosciences
1 antibody
OriGene
3 antibodies
Biorbyt
12 antibodies
Bioworld Technology, Inc
2 antibodies
Boster Biological Technology
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Abgent
1 antibody
Cell Signaling Technology, Inc
1 antibody
MyBioSource
3 antibodies
Aviva Systems Biology
1 antibody
RayBiotech, Inc.
1 antibody
United States Biological
38 antibodies
Abbexa
6 antibodies
Sigma-Aldrich
2 antibodies
Abbiotec
1 antibody
Creative Diagnostics
2 antibodies
Creative Biolabs
4 antibodies
Acris Antibodies GmbH
2 antibodies