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TGFB2
Transforming growth factor beta 2This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Top validated antibodies |
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| Proteintech Group |  19999-1-AP |
28 references | Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | 710276 |
1 references | Polyclonal |
WB
FC
OA
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| antibodies-online | ABIN2838086 |
2 references | Monoclonal |
WB
ICC
IHC
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| R&D Systems | MAB612-100 |
3 references | Monoclonal |
WB
EL
IHC
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| Novus Biologicals | AB-12-NA |
6 references | Polyclonal |
WB
BN
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