DMRT1

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]

Description

Doublesex and mab-3 related transcription factor 1

Tissue specificity

Tissue enriched (testis)

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

9 (841690 - 969090)

Ensembl ID

ENSG00000137090  (ver. 103.38)

Orthologs

Mouse Dmrt1: ENSMUSG00000024837

UniProt

Q9Y5R6

neXtProt

NX_Q9Y5R6

Human splice variants
Mouse splice variants

Protein structure