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CYBB
Cytochrome b-245 beta chainCGD, GP91-PHOX, NOX2
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  19013-1-AP |
159 references | Polyclonal |
WB
EL
ICC
IHC
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| Boster Biological Technology | A00328-3 |
2 references | Polyclonal |
WB
EL
ICC
IHC
FC
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| LSBio | LS-C336199 |
Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NBP2-41291 |
2 references | Polyclonal |
WB
EL
ICC
IHC
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| NSJ Bioreagents | RQ6168 |
Polyclonal |
WB
EL
ICC
IHC
FC
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