ESPL1

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]). [supplied by OMIM, Nov 2010]

Description

Extra spindle pole bodies like 1, separase

Tissue specificity

Tissue enhanced (bone marrow, esophagus, lymphoid tissue)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (53268299 - 53293638)

Ensembl ID

ENSG00000135476  (ver. 103.38)

Orthologs

Mouse Espl1: ENSMUSG00000058290

UniProt

Q14674

neXtProt

NX_Q14674

Human splice variants
Mouse splice variants

Protein structure