CCL26

This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]

Description

C-C motif chemokine ligand 26

Tissue specificity

Tissue enhanced (ovary, pituitary gland)

Predicted location

Secreted to blood

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

7 (75769533 - 75789896)

Ensembl ID

ENSG00000006606  (ver. 103.38)

Orthologs

-

UniProt

Q9Y258

neXtProt

NX_Q9Y258

Human splice variants

Protein structure