MAP4

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Description

Microtubule associated protein 4

Tissue specificity

Tissue enhanced (brain, skeletal muscle)

Subcell location

Plasma membrane, Microtubules, Cytosol

Predicted location

Intracellular

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (47850690 - 48089272)

Ensembl ID

ENSG00000047849  (ver. 103.38)

Orthologs

Mouse Map4: ENSMUSG00000032479

UniProt

P27816

neXtProt

NX_P27816

Human splice variants
Mouse splice variants

Protein structure