Tissue expression
Cell line expression
Protein structure
ISCU
Iron-sulfur cluster assembly enzymehnifU, ISU2, NIFUN
This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016]
Top validated antibodies |
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Proteintech Group | 14812-1-AP | 17 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Invitrogen Antibodies | 14812-1-AP | Polyclonal |
WB
ICC
IHC
OA |
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Novus Biologicals | H00023479-M01 | 1 references | Monoclonal |
WB
EL
ICC
|
|
Abnova Corporation | H00023479-M01 | 1 references | Monoclonal |
WB
EL
ICC
|
|
NovoPro Bioscience Inc. | 111936 | Polyclonal |
WB
EL
ICC
IP
IHC
|
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Supportive data in Antibodypedia
Data presented on provider website
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Recommended by provider