RTKN

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Description

Rhotekin

Tissue specificity

Tissue enhanced (brain, liver)

Subcell location

Nucleoplasm, Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (74425835 - 74442422)

Ensembl ID

ENSG00000114993  (ver. 103.38)

Orthologs

Mouse Rtkn: ENSMUSG00000034930

UniProt

Q9BST9

neXtProt

NX_Q9BST9

Human splice variants
Mouse splice variants

Protein structure