HIRA

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]

Description

Histone cell cycle regulator

Tissue specificity

Tissue enhanced (thyroid gland)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (19330698 - 19447450)

Ensembl ID

ENSG00000100084  (ver. 103.38)

Orthologs

Mouse Hira: ENSMUSG00000022702

UniProt

P54198

neXtProt

NX_P54198

Human splice variants
Mouse splice variants

Protein structure