Tissue expression
Cell line expression
Protein structure
PPM1D
Protein phosphatase, Mg2+/Mn2+ dependent 1DPP2C-DELTA, Wip1
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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GeneTex | GTX31604 | Polyclonal |
WB
EL
ICC
IHC |
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Boster Biological Technology | A01576-1 | Polyclonal |
WB
EL
ICC
FC |
||
Proteintech Group | 67440-1-Ig | Monoclonal |
WB
EL
ICC
IHC |
||
Invitrogen Antibodies | 67440-1-IG | Monoclonal |
WB
ICC
IHC
|
||
Biorbyt | orb1467381 | Monoclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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Recommended by provider