Tissue expression
Cell line expression
DDR1
gene productCAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
- Description
- Discoidin domain receptor tyrosine kinase 1
- Tissue specificity
- Low tissue specificity
- Subcell location
- Nucleoplasm, Cell Junctions
- Predicted location
- Intracellular, Membrane
- Protein family
- CD markers
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
- Chromosome
- 6:p21.33 (30876421 - 30900156)
- Ensembl ID
- ENSG00000204580 (ver. 103.38)
- Orthologs
- Mouse Ddr1: ENSMUSG00000003534
- UniProt
- Q08345
- neXtProt
- NX_Q08345
Human splice variants
Mouse splice variants
Ensembl | UniProt | RefSeq | Entrez |
---|---|---|---|
ENSMUST00000003628 ENSMUSP00000003628 |
Q03146.189 Q03146 | Ddr1 12305 | |
ENSMUST00000097333 ENSMUSP00000094945 |
Q03146.189 Q03146 | NP_766550.1 NP_766550 | Ddr1 12305 |
ENSMUST00000117301 ENSMUSP00000112570 |
Q03146.189 Q03146 | NP_031610.1 NP_031610 | Ddr1 12305 |
ENSMUST00000119825 ENSMUSP00000113062 |
Q03146.189 Q03146 | NP_001185762.1 NP_001185762 | Ddr1 12305 |
ENSMUST00000134995 ENSMUSP00000117301 |
Ddr1 12305 | ||
ENSMUST00000135078 ENSMUSP00000122191 |
Ddr1 12305 | ||
ENSMUST00000145900 ENSMUSP00000122361 |
Ddr1 12305 | ||
ENSMUST00000146472 ENSMUSP00000119397 |
Ddr1 12305 | ||
ENSMUST00000148065 ENSMUSP00000120635 |
Ddr1 12305 | ||
ENSMUST00000155628 ENSMUSP00000133659 |
Ddr1 12305 | ||
ENSMUST00000155957 ENSMUSP00000117427 |
Ddr1 12305 | ||
ENSMUST00000166980 ENSMUSP00000133047 |
Q03146.189 Q03146 | NP_001185760.1 NP_001185760 | Ddr1 12305 |
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.