Tissue expression
Cell line expression
Protein structure
DDR1
Discoidin domain receptor tyrosine kinase 1CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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NSJ Bioreagents | RQ5574 | Polyclonal |
WB
EL
ICC
IHC
FC
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antibodies-online | ABIN2841792 | 3 references | Polyclonal |
WB
IHC
FC
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Boster Biological Technology | A00905 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Abgent | AP7294c | Polyclonal |
WB
ICC
IHC
FC |
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Invitrogen Antibodies | PA5-14177 | Polyclonal |
WB
ICC
IHC
FC |
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