Tissue expression
Cell line expression
Protein structure
MED12
Mediator complex subunit 12ARC240, CAGH45, FGS1, HOPA, KIAA0192, Kto, OKS, OPA1, TNRC11, TRAP230
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
Top validated antibodies |
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Novus Biologicals | NB100-2357 | 12 references | Polyclonal |
WB
IP
IHC
ChIP |
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antibodies-online | ABIN250749 | 11 references | Polyclonal |
WB
ICC
IP
IHC |
|
Atlas Antibodies | HPA003185 | Polyclonal |
WB
ICC
IHC
|
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Invitrogen Antibodies | A700-084 | Monoclonal |
WB
ICC
IP
IHC
OA
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Proteintech Group | 20028-1-AP | 2 references | Polyclonal |
WB
EL
ICC
|
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