CYFIP1

This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]

Description

Cytoplasmic FMR1 interacting protein 1

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

15 (22867052 - 22981063)

Ensembl ID

ENSG00000273749  (ver. 103.38)

Orthologs

Mouse Cyfip1: ENSMUSG00000030447

UniProt

Q7L576

neXtProt

NX_Q7L576

Human splice variants
Mouse splice variants

Protein structure