Tissue expression
Cell line expression
Protein structure
BRAF
B-Raf proto-oncogene, serine/threonine kinaseBRAF1
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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Proteintech Group | 20899-1-AP | 6 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Novus Biologicals | NBP1-47668 | 1 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
Invitrogen Antibodies | 14582-1-AP | Polyclonal |
WB
ICC
IP
IHC
ChIP
OA |
||
antibodies-online | ABIN2841938 | 3 references | Polyclonal |
WB
ICC
IHC
FC |
|
OriGene | TA500431 | Monoclonal |
WB
ICC
IP
IHC
FC
|
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
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Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider